Involvement of peripheral opioid receptors in electroacupuncture analgesia for carrageenan-induced hyperalgesia

Taguchi, Reina; Taguchi, Tatsuki; Kono, Hiroshi

doi:10.1016/j.brainres.2010.08.014

Cited by 47 publications

(33 citation statements)

References 27 publications

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“…2) dosage-dependently blocked electroacupuncture-produced inhibition of mechanical hyperalgesia assessed through paw pressure threshold. 4,5 Consistent with these results, intraplantar naloxone methiodide, a peripherally acting opioid receptor antagonist and an antibody against β-endorphin, eliminated electroacupuncture-produced inhibition of CFA-induced thermal hyperalgesia assessed with paw withdrawal latency (PWL) in response to radiant thermal stimuli. 6 These data indicate that electroacupuncture induces release of endogenous opioids from lymphocytes, monocytes/macrophages, and granulocytes 7,8 into inflamed skin.…”

Section: Inflammatory Pain Animal Modelsmentioning

confidence: 61%

Mechanisms of Acupuncture–Electroacupuncture on Persistent Pain

Zhang

Lao

Ren³

et al. 2014

Anesthesiology

648

465

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In the last decade, preclinical investigations of electroacupuncture mechanisms on persistent tissue-injury (inflammatory), nerve-injury (neuropathic), cancer, and visceral pain have increased. These studies show that electroacupuncture activates the nervous system differently in health than in pain conditions, alleviates both sensory and affective inflammatory pain, and inhibits inflammatory and neuropathic pain more effectively at 2–10 Hz than at 100 Hz. Electroacupuncture blocks pain by activating a variety of bioactive chemicals through peripheral, spinal, and supraspinal mechanisms. These include opioids, which desensitize peripheral nociceptors and reduce pro-inflammatory cytokines peripherally and in the spinal cord, and serotonin and norepinephrine, which decrease spinal n-methyl-d-aspartate receptor subunit GluN1 phosphorylation. Additional studies suggest that electroacupuncture, when combined with low dosages of conventional analgesics, provides effective pain management that can forestall the side effects of often-debilitating pharmaceuticals.

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Section: Inflammatory Pain Animal Modelsmentioning

confidence: 61%

Mechanisms of Acupuncture–Electroacupuncture on Persistent Pain

Zhang

Lao

Ren³

et al. 2014

Anesthesiology

648

465

View full text Add to dashboard Cite

show abstract

“…They postulated that the mechanisms of AA is through peripheral stimulation of acupoints and mediated by mobilization of central neuropeptides [9,11,12]. Furthermore, stimulation by different frequencies (2, 15, 100 Hz) on destined points on the skin surface mobilizes different neuropeptides (β-endorphin, enkephalin, dynorphin), bind to the corresponding receptors (μ-opioid receptor, δ-opioid receptor, κ-opioid receptor) and induce analgesic effects, respectively [9,13].…”

Section: The Role Of Endogenous Opioids In Acupuncture Analgesiamentioning

confidence: 99%

History of Acupuncture

Chiu¹

2013

Acupuncture for Pain Management

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“…Local endorphins and their receptors (e.g., μ, δ, κ) have been found on nociceptive afferents in inflammatory conditions [21,22]. The different endorphins are secreted from inflammatory cells in the tissue after an injury.…”

Section: The Mechanism Of Acupuncture For Chronic Prostatitis/chronicmentioning

confidence: 99%

Use of Acupuncture as a Treatment Method for Chronic Prostatitis/Chronic Pelvic Pain Syndromes

Lee

2011

Curr Urol Rep

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Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is the most common category of clinical prostatitis. The etiologic factors of CP/CPPS still remain unknown, and standard therapies often fail to achieve sustainable amelioration of symptoms; therefore, various treatment therapies have been approached. Recently, there is increasing evidence that acupuncture could be a safe and effective treatment in managing CP/CPPS. However, acupuncture therapy still is ranked as low-priority treatment, which results from the fact that the studies, mostly reported in nontraditional medical journals, had not employed standard definitions of the condition or validated-outcome parameters, and that the mechanism of acupuncture effects on CP/CPPS remains to be elucidated. In this article, we review the recent clinical research using acupuncture to reveal its clinical utility for CP/CPPS and the possible mechanisms of action. This article could encourage health care providers and urologists to apply acupuncture for managing pains of CP/CPPS with standard treatment.

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Involvement of peripheral opioid receptors in electroacupuncture analgesia for carrageenan-induced hyperalgesia

Cited by 47 publications

References 27 publications

Mechanisms of Acupuncture–Electroacupuncture on Persistent Pain

Mechanisms of Acupuncture–Electroacupuncture on Persistent Pain

History of Acupuncture

Use of Acupuncture as a Treatment Method for Chronic Prostatitis/Chronic Pelvic Pain Syndromes

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