2017
DOI: 10.3892/mmr.2017.6151
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Involvement of retinoblastoma-associated protein 48 during photodynamic therapy of cervical cancer cells

Abstract: 5-Aminolevulinic acid-mediated photodynamic therapy (ALA‑PDT) is an effective treatment option for cervical intraepithelial neoplasia, the precancerous lesion of cervical cancer, and early cervical cancer, particularly for young or nulliparous women who want to remain fertile. A previous report described the involvement of histone deacetylases (HDAC) during ALA‑PDT mediated apoptosis in the cerebral cortex of a mouse model. Retinoblastoma‑associated protein 48 (RbAp48), a highly abundant component of HDACs, is… Show more

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Cited by 5 publications
(3 citation statements)
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“…Notably, 5-aminole-vulinic acid photodynamic therapy (ALA-PDT), an effective treatment for HPV-related conditions, has been reported to elevate RBBP4 expression in HPV16 immortalized cervical epithelial H8 cells ( 154 ). A subsequent decrease in RBBP4 can mitigate the inhibitory effects of ALA-PDT-induced cell proliferation and apoptosis in cervical cancer cells ( 155 ). These studies demonstrated that RBBP4 may function as a tumor suppressor in cervical cancer and could serve as a promising therapeutic target for future cervical cancer intervention.…”
Section: Expression and Function Of Rbbp4/7 In Diseasesmentioning
confidence: 99%
See 1 more Smart Citation
“…Notably, 5-aminole-vulinic acid photodynamic therapy (ALA-PDT), an effective treatment for HPV-related conditions, has been reported to elevate RBBP4 expression in HPV16 immortalized cervical epithelial H8 cells ( 154 ). A subsequent decrease in RBBP4 can mitigate the inhibitory effects of ALA-PDT-induced cell proliferation and apoptosis in cervical cancer cells ( 155 ). These studies demonstrated that RBBP4 may function as a tumor suppressor in cervical cancer and could serve as a promising therapeutic target for future cervical cancer intervention.…”
Section: Expression and Function Of Rbbp4/7 In Diseasesmentioning
confidence: 99%
“…RBBP4 is also considered a potential target for treating CRC with PPD ( 119 ). In therapeutic contexts, RBBP4 expression is significantly increased in cervical cancer cell lines treated with ALA-PDT ( 155 ), and upregulation of RBBP4 has been found to induce radiosensitivity in BC, melanoma and TNBC ( 180 ). Conversely, reduced levels of RBBP7 may be associated with survival rates and chemoresistance phenotypes in basal-like BC ( 152 ).…”
Section: Rbbp4/7 As Potential Targets For Human Disease Treatmentmentioning
confidence: 99%
“…Class I, II, IV are Zn2+-dependent HDACs [18]. Retinoblastoma associated protein 48 (rb ap48) is a component of HDACs and a key mediator for controlling the transformation activity of HPV16 in cervical cancer cells [19]. Because of its significant role in cancer, HDAC protein shave becomes a potential target for cancer treatment.…”
Section: Histone Deacetylasesmentioning
confidence: 99%