Involvement of serotonin system in bulimia

Marazziti, Donatella; Macchi, E.; Rotondo, Alessandro; Placidi, Gian Franco; Cassano, Giovanni B.

doi:10.1016/0024-3205(88)90362-1

Cited by 35 publications

(14 citation statements)

References 30 publications

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“…(2) Previous demonstrations of reduced plateletbinding density for selective 5-HT reuptake inhibitors in actively bulimic women (Marazziti et al, 1988;Steiger et al, 2000Steiger et al, , 2001bSteiger et al, , 2005 are consistent with documented reduction of central transporter availability in BN (Tauscher et al, 2001). (3) Peripheral alterations in binding for selective 5-HT reuptake inhibitors correspond to response of depressive symptoms to pharmacotherapy (Freeman et al, 1993).…”

Section: Discussionmentioning

confidence: 65%

“…Platelet binding of 5-HT reuptake inhibitors is believed to model aspects of central 5-HT transporter (reuptake) function (Lesch et al, 1993). Previous platelet-binding studies in actively bulimic women have used [ 3 H]imipramine (Marazziti et al, 1988) (Steiger et al, 2000(Steiger et al, , 2001a to show markedly reduced density (B max ) of binding sitesFfindings that are compatible with documented reduction of central transporter availability in BN (Tauscher et al, 2001). …”

Section: Introductionmentioning

confidence: 83%

“…Active bulimia nervosa (BN) sufferers display altered serotonin (5-hydroxytryptamine (5-HT)) system functioning, as evinced by reduced platelet binding of 5-HT uptake inhibitors (Marazziti et al, 1988;Steiger et al, 2000), reduced central 5-HT transporter availability (Tauscher et al, 2001), blunted neuroendocrine responses to 5-HT precursors and agonists (Levitan et al, 1997;Steiger et al, 2001a, b), and decreased 5-HT metabolites in cerebrospinal fluid (Jimerson et al, 1992). As food restriction is known to alter central 5-HT activity in animals (Huether et al, 1997;Zhou et al, 1996) and in humans (Goodwin et al, 1987), abnormal 5-HT function in BN could, reasonably, be a consequence of disordered eating.…”

Section: Introductionmentioning

confidence: 99%

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Reduced Density of Platelet-Binding Sites for [3H]Paroxetine in Remitted Bulimic Women

Steiger

Richardson

Israël

et al. 2005

Neuropsychopharmacol

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Findings show brain serotonin (5-hydroxytryptamine (5-HT)) activity to be altered in individuals who have had bulimia nervosa (BN), even after substantial remission of symptoms. Such findings could reflect persistent sequelae due to BN, or a vulnerability 'trait' that exists independently of active eating-disorder manifestations. We compared women with full-blown BN (BN; n ¼ 22), BN in remission (BN-R; n ¼ 11), and no eating or psychiatric disturbances (n ¼ 22) on measures of platelet [3 H]paroxetine binding, eating symptoms and psychopathology. The BN-R group showed normal-range scores on eating and psychopathological symptoms, but reductions in density (B max ) of binding sites for paroxetine similar to those obtained in the actively ill women. Both BN groups had substantially lower B max than did healthy controls. Our results corroborate other findings indicating recovered BN patients to have anomalous 5-HT functioning. While such effects could represent a lasting 'injury' to the system, reported covariations between personality traits and 5-HT indices in BN encourage us to favor the argument that some alterations of 5-HT activity (in this case, consistent with reduced transporter activity) represent a 'trait' associated with the risk of developing BN and/or associated psychopathology.

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Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

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Reduced Density of Platelet-Binding Sites for [3H]Paroxetine in Remitted Bulimic Women

Steiger

Richardson

Israël

et al. 2005

Neuropsychopharmacol

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“…Active bulimia nervosa (BN) sufferers display altered serotonin (5-hydroxytryptamine: 5-HT) system activity, as evinced by reduced platelet binding of 5-HT reuptake inhibitors (Marazziti et al, 1988;Steiger et al, 2000, central 5-HT transporter availability (Tauscher et al, 2001), neuroendocrine responses to 5-HT precursors and 5-HT agonists/partial agonists (Levitan et al, 1997;, and (in high-frequency bingers) cerebrospinal fluid (CSF) hydroxyindoleacetic acid (5-HIAA) (Jimerson et al, 1992). As calorie deprivation produces measurable alterations of endocrine responses after 5-HT stimulation in humans (Cowen et al, 1996) and of 5-HT transporter activity in animals (Huether et al, 1997), intermittent caloric restraint (characteristic of active bulimics) might contribute to altered 5-HT status in BN.…”

Section: Introductionmentioning

confidence: 99%

“…Similar correspondences between platelet and central 5-HT indices have been noted in bulimic populations. Studies using platelet [ 3 H-]imipramine (Marazziti et al, 1988) or [ 3 H-]paroxetine (Steiger et al, 2000 binding have shown marked reductions in peripheral 5-HT transport density (B max ), whereas single photon emission computed tomography confirms reduced central 5-HT transporter availability (Tauscher et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Intrafamilial Correspondences on Platelet [3H-]Paroxetine-Binding Indices in Bulimic Probands and their Unaffected First-Degree Relatives

Steiger

Gauvin

Joober

et al. 2006

Neuropsychopharmacol

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Reduced brain serotonin (5-hydroxytryptamine: 5-HT) transporter activity has been associated with susceptibility to various forms of psychopathology, including bulimia nervosa (BN) and related syndromes characterized by appetitive or behavioural dysregulation. We applied density (B max ) of platelet [ 3 H-]paroxetine binding as a proxy for central 5-HT reuptake activity in two groups of women (33 with BN-spectrum disorders and 19 with no apparent eating or psychiatric disorders), most of these individuals' mothers (31 and 18, respectively), and a small sampling of their sisters (seven and eight, respectively). Hierarchical linear modeling techniques were used to account for nesting of individuals within families and diagnostic groupings. Bulimic probands, their mothers, and their sisters all displayed significantly lower density (B max ) of platelet-paroxetine binding than did 'control' probands, mothers, or sistersFeven when relatives showing apparent eating or psychiatric disturbances were excluded. In addition, in bulimic probands and mothers, significant within-family correlations were obtained on B max . These findings imply a heritable trait (or endophenotype), linked to 5-HT activity, and carried by BN sufferers and their first-degree relatives (even when asymptomatic). We propose that, under conducive circumstances, such a trait may increase risk of binge-eating behavior, or associated symptoms of affective or behavioral dysregulation.

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Hormonal and Subjective Responses to Intravenous meta-Chlorophenylpiperazine in Bulimia Nervosa

Levitan¹

1997

Arch Gen Psychiatry

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Involvement of serotonin system in bulimia

Cited by 35 publications

References 30 publications

Reduced Density of Platelet-Binding Sites for [3H]Paroxetine in Remitted Bulimic Women

Reduced Density of Platelet-Binding Sites for [3H]Paroxetine in Remitted Bulimic Women

Intrafamilial Correspondences on Platelet [3H-]Paroxetine-Binding Indices in Bulimic Probands and their Unaffected First-Degree Relatives

Hormonal and Subjective Responses to Intravenous meta-Chlorophenylpiperazine in Bulimia Nervosa

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