2019
DOI: 10.1007/s00380-018-01323-8
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Involvement of sphingosine-1-phosphate receptors 2/3 in IR-induced sudden cardiac death

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Cited by 7 publications
(4 citation statements)
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“…Additionally, Means et al showed that activation of both S1PR2 and S1PR3 receptors are involved in cardioprotection against I/R injury, since the knockout of either S1PR2 or S1PR3 alone does not influence the in vivo response to I/R injury, while the knockout of both receptors significantly increases the I/R injury-related infarct size ( 130 ). Recently, Zhang et al ( 131 ) in the rat model of I/R showed that blockage of the S1PR2/S1PR3 receptors with specific antagonists increased IR-induced mortality and infarction size, induced conduction abnormalities, and decreased the fractional shortening and ejection fraction of LV. While pre-treatment with S1PR2 and S1PR3 agonists at least partially reversed those changes ( 131 ).…”
Section: Sphingolipids In Cardiovascular Diseasesmentioning
confidence: 99%
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“…Additionally, Means et al showed that activation of both S1PR2 and S1PR3 receptors are involved in cardioprotection against I/R injury, since the knockout of either S1PR2 or S1PR3 alone does not influence the in vivo response to I/R injury, while the knockout of both receptors significantly increases the I/R injury-related infarct size ( 130 ). Recently, Zhang et al ( 131 ) in the rat model of I/R showed that blockage of the S1PR2/S1PR3 receptors with specific antagonists increased IR-induced mortality and infarction size, induced conduction abnormalities, and decreased the fractional shortening and ejection fraction of LV. While pre-treatment with S1PR2 and S1PR3 agonists at least partially reversed those changes ( 131 ).…”
Section: Sphingolipids In Cardiovascular Diseasesmentioning
confidence: 99%
“…Recently, Zhang et al ( 131 ) in the rat model of I/R showed that blockage of the S1PR2/S1PR3 receptors with specific antagonists increased IR-induced mortality and infarction size, induced conduction abnormalities, and decreased the fractional shortening and ejection fraction of LV. While pre-treatment with S1PR2 and S1PR3 agonists at least partially reversed those changes ( 131 ). Afterward, the interaction of S1P with its receptors activates intracellular pathways also having a cardioprotective effect against ischemia.…”
Section: Sphingolipids In Cardiovascular Diseasesmentioning
confidence: 99%
“…The IR-S1P2/3-Cx43-sudden cardiac death (SCD) signaling pathway could be involved in IR-induced cardiac death (X. Zhang et al, 2019).…”
Section: The Role Of S1p3 In I/rmentioning
confidence: 99%
“…Moreover, the I/R‐S1P2/3‐induced lethality could be reduced by applying the Cx43 uncouplers, heptanol and Gap26. The IR‐S1P2/3‐Cx43‐sudden cardiac death (SCD) signaling pathway could be involved in IR‐induced cardiac death (X. Zhang et al, 2019).…”
Section: The Role Of S1p3 In I/rmentioning
confidence: 99%