Involvement of spindles in memory consolidation is slow wave sleep-specific

Cox, Roy; Hofman, W.F.; Talamini, Lucia M.

doi:10.1101/lm.026252.112

Cited by 152 publications

(139 citation statements)

References 31 publications

(18 reference statements)

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“…Spindle spiking patterns induce synaptic plasticity in slice preparations (Rosanova and Ulrich, 2005) and may thus facilitate plasticity during sleep. This notion is supported, albeit indirectly, by a substantial literature linking spindles to learning, consolidation, and memory reactivation (Gais et al, 2002;Schabus et al, 2004;Cox et al, 2012Cox et al, , 2014a. Furthermore, gamma activity is indicative of local cortical information processing and is optimally suited for spiketiming dependent plasticity (Jutras and Buffalo, 2010).…”

Section: Discussionmentioning

confidence: 63%

“…Such sleep-related memory stabilization is widely held to involve the reactivation of memory traces in hippocampo-neocortical networks, leading to the formation of hippocampus-independent links between cortically distributed memory representations (Marr, 1971;Frankland and Bontempi, 2005). This hippocampo-cortical dialogue is thought to rely on the temporal coupling (Buzsáki, 1996;Diekelmann and Born, 2010) of SOs, sleep spindles-themselves tightly linked to learning and memory consolidation processes (Gais et al, 2002;Schabus et al, 2004;Cox et al, 2012Cox et al, , 2014a)-and hippocampal ripples, during which previously acquired neuronal patterns are replayed (O'Neill et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Slow Oscillations during Sleep Coordinate Interregional Communication in Cortical Networks

et al. 2014

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Large-amplitude sleep slow oscillations group faster neuronal oscillations and are of functional relevance for memory performance. However, relatively little is known about the impact of slow oscillations on functionally coupled networks. Here, we provide a comprehensive view on how human slow oscillatory dynamics influence various measures of brain processing. We demonstrate that slow oscillations coordinate interregional cortical communication, as assessed by phase synchrony in the sleep spindle frequency range and cross-frequency coupling between spindle and beta activity. Furthermore, we show that the organizing role of slow oscillations is restricted to circumscribed topographical areas. These findings add importantly to our basic understanding of the orchestrating role of slow oscillations. In addition, they are of considerable relevance for accounts of sleep-dependent memory reprocessing and consolidation.

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Section: Discussionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Slow Oscillations during Sleep Coordinate Interregional Communication in Cortical Networks

et al. 2014

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“…Griessenberger et al (2012) found that an increase of the 8-12 Hz band during sleep spindles in SWS was correlated to better retention of the order of objects that had been memorized before sleep when memories were tested three days later (cf. also Cox, Hofman, & Talamini, 2012, although their focus was on the 11-16 Hz band).…”

Section: Sleep-eeg Resultsmentioning

confidence: 99%

Insights into sleep's role for insight: Studies with the number reduction task

Verleger¹,

Rose²,

Wagner³

et al. 2013

ACP

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in recent years, vibrant research has developed on "consolidation" during sleep: to what extent are newly experienced impressions reprocessed or even restructured during sleep? we used the number reduction task (nrt) to study if and how sleep does not only reiterate new experiences but may even lead to new insights. in the nrt, covert regularities may speed responses. this implicit acquisition of regularities may become explicitly conscious at some point, leading to a qualitative change in behavior which reflects this insight. By applying the nrt at two consecutive sessions separated by an interval, we investigated the role of sleep in this interval for attaining insight at the second session. in the first study, a night of sleep was shown to triple the number of participants attaining insight above the base rate of about 20%. in the second study, this hard core of 20% discoverers differed from other participants in their task-related eeg potentials from the very beginning already. in the third study, the additional role of sleep was specified as an effect of the deep-sleep phase of slow-wave sleep on participants who had implicitly acquired the covert regularity before sleep. it was in these participants that a specific increase of eeg during slow-wave sleep in the 10-12 hz band was obtained. these results support the view that neuronal memory reprocessing during slow-wave sleep restructures task-related representations in the brain, and that such restructuring promotes the gain of explicit knowledge. AbstrAct Keywords

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“…Mednick et al (2013) experimentally increased spindle density with a drug during a daytime nap, which led to better wordpair associate memory performance compared with a placebo. A recent study by Cox, Hofman, and Talamini (2012) indicated that the beneficial effect of sleep spindles on memory is specific to SWS by showing not only that spindle density in SWS is higher than in light sleep (S2) but that only spindle density in SWS and not in light sleep was positively correlated with memory performance. This pattern suggests that the beneficial effect of sleep spindles on memory consolidation is dependent on the co-occurrence of slow oscillations (Cox et al, 2012).…”

Section: Introductionmentioning

confidence: 95%

“…This should be reflected by less deterioration from pre-to post-sleep in AM as compared to IM performance for the nap compared to control group. Furthermore, AM posttest performance within the nap group should be associated with high spindle density (in particular spindle density during SWS (Cox et al, 2012)). Corresponding correlations between IM performance and sleep EEG parameters, as well as group differences in IM performance and the ERP correlate of familiarity at posttest were not expected.…”

Section: Introductionmentioning

confidence: 98%

Nap sleep preserves associative but not item memory performance

Studte

Bridger

Mecklinger

2015

Neurobiology of Learning and Memory

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Many studies have shown that sleep improves memory performance, and that even short naps during the day are beneficial. Certain physiological components of sleep such as spindles and slow-wave-sleep are thought to be particularly important for memory consolidation. The aim of this experiment was to reveal the role of naps for hippocampus-dependent associative memory (AM) and hippocampus-independent item memory (IM) alongside their corresponding ERP old/new effects. Participants learnt single words and word-pairs before performing an IM- and an AM-test (baseline). One group was subsequently allowed to nap (∼90min) while the other watched DVDs (control group). Afterwards, both groups performed a final IM- and AM-test for the learned stimuli (posttest). IM performance decreased for both groups, while AM performance decreased for the control group but remained constant for the nap group, consistent with predictions concerning the selective impact of napping on hippocampus-dependent recognition. Putative ERP correlates of familiarity and recollection were observed in the IM posttest, whereas only the later recollection-related effect was present in the AM test. Notably, none of these effects varied with group. Positive correlations were observed between spindle density during slow-wave-sleep and AM posttest performance as well as between spindle density during non-REM sleep and AM baseline performance, showing that successful learning and retrieval both before and after sleep relates to spindle density during nap sleep. Together, these results speak for a selective beneficial impact of naps on hippocampus-dependent memories.

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Involvement of spindles in memory consolidation is slow wave sleep-specific

Cited by 152 publications

References 31 publications

Slow Oscillations during Sleep Coordinate Interregional Communication in Cortical Networks

Slow Oscillations during Sleep Coordinate Interregional Communication in Cortical Networks

Insights into sleep's role for insight: Studies with the number reduction task

Nap sleep preserves associative but not item memory performance

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