Involvement of subdivisions of the medial prefrontal cortex in learned cardiac adjustments in rabbits.

Powell, D. A.; Watson, Karen; Maxwell, Brian

doi:10.1037/0735-7044.108.2.294

Cited by 86 publications

(101 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results contradict this presumption. The study of Powell et al [42] points also in the direction of a functional heterogeneity between areas 24, 32 and 25.…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Effects of an electrolytic lesion of the prelimbic area on anxiety-related and cognitive tasks in the rat

Maaswinkel

Gispen

Spruijt

1996

Behavioural Brain Research

View full text Add to dashboard Cite

The aim of this paper was to study the role of the prelimbic area of rats in response selection• A bilateral electrolytic lesion was made in the prelimbic area. The rats were tested in the Morris water-maze, the conditioned shock-prod burying test, the elevated plus-maze, a modified open field test, and the step-through passive avoidance test. In the water-maze during initial acquisition, the latency times of the lesioned rats were not different from those of the controls, but they found the platform faster than the shamoperated rats after the platform was placed in a new position. The lesion did not affect performance in the shock-prod burying test. In the elevated plus-maze the lesioned rats were more active than the sham-operated rats and spent more time on the open arms. In the open field there was no difference between lesioned and sham-operated rats with regard to distance travelled or the time spent near the object in the center of the open field. In the passive avoidance test the lesioned rats had a shorter latency time to enter the shock compartment during the retention trial than the sham-operated rats did. The results were discussed in relation to those of similar studies. The extent and precise localisation of the lesion seems to be crucial for the outcome: lesions confined to the prelimbic area may have the opposite effects of larger lesions. Furthermore, it may well be that the prelimbic area is only involved in processing of stimuli of a specific sensory modality, as made probable by the results of different conditioned reinforcement tasks. Finally, it was stated that we still lack a hypothesis about the precise role of the prelimbic area in response selections.

show abstract

“…Our results contradict this presumption. The study of Powell et al [42] points also in the direction of a functional heterogeneity between areas 24, 32 and 25.…”

Section: Discussionmentioning

confidence: 94%

“…According to Powell et al [42] this area is involved in autonomic conditioned responses, such as conditioned bradycardia. Similarly, Terreberry and Neafsey [50] call the medial prefrontal cortex a visceral motor region.…”

Section: Introductionmentioning

confidence: 99%

Effects of an electrolytic lesion of the prelimbic area on anxiety-related and cognitive tasks in the rat

Maaswinkel

Gispen

Spruijt

1996

Behavioural Brain Research

View full text Add to dashboard Cite

show abstract

“…For example, studies employing traditional Pavlovian conditioning paradigms have shown that aversively conditioned stimuli can evoke learning-related changes in neuronal activity within prelimbic and cingulate areas of the mPFC Peterson 1986;Powell et al 1996), and increase dopamine and serotonin efflux in these regions (Wedzony et al 1996;Yoshioka et al 1995Yoshioka et al , 1996. Lesions of the mPFC also can disrupt Pavlovian conditioned responses to sucrose or foot-shock related stimuli (Bussey et al 1997;McLaughlin and Powell 1999;Powell et al 1994). Studies of conditioned drug effects have further shown that cocaine-related stimuli can increase serotonin efflux and stimulate the expression of Fos-related proteins within the mPFC in rats (Brown and Fibiger 1992;Carey and Damianopoulos 1994;Franklin and Druhan 2000;Neisewander et al 2000), whereas lesions of this region interfere with the development of conditioned preferences for a cocaineassociated environment and with the expression of cocaine-induced sensitization effects that depend heavily on contextual conditioning (Isaac et al 1989;Pierce et al 1998;Tzschentke and Schmidt 1998).…”

Section: Discussionmentioning

confidence: 99%

Involvement of the Nucleus Accumbens and Medial Prefrontal Cortex in the Expression of Conditioned Hyperactivity to a Cocaine-Associated Environment in Rats

Franklin

Druhan

2000

Neuropsychopharmacology

View full text Add to dashboard Cite

This study examined the roles of the nucleus accumbens (NAc), medial prefrontal cortex, basolateral amygdala, and ventral subiculum of the hippocampus in the expression of Pavlovian conditioned hyperactivity responses to cocainerelated stimuli. This was accomplished by pharmacologically inhibiting these regions prior to drug-free tests for conditioned hyperactivity in an environment previously associated with cocaine. The results indicate that conditioned hyperactivity could be disrupted by infusions of the baclofen (0.2 nmol/0.5 l/side) Environmental stimuli associated with cocaine use can elicit a variety of conditioned physiological and subjective responses in abstinent cocaine addicts (Childress et al. 1999;Newlin 1992). These Pavlovian conditioned responses may contribute to the maintenance of drug-taking habits in active cocaine users, and promote relapse in detoxified addicts. In rats, environments associated with cocaine evoke conditioned locomotor activation in the absence of the drug (Barr et al. 1983;Cervo and Samanin 1996;DiCiano et al. 1998a;Stewart et al. 1984). This Pavlovian conditioned behavioral activation may be analogous to some of the conditioned subjective and physiological responses elicited by cocaine-related stimuli in human drug addicts (Pert 1994). Accordingly, studies of the neurobiological mechanisms underlying conditioned behavioral activation in rats may provide valuable information that could facilitate the development of pharmacological treatments for cocaine addiction.Several lines of evidence suggest that the nucleus accumbens (NAc) may regulate the expression of conditioned responses to stimuli associated with cocaine or other psychostimulants. For example, 6-OHDA lesions of mesoaccumbens dopamine terminals post-conditioning can interfere with conditioned hyperactivity elicited NO . 6 by an environment repeatedly paired with amphetamine (Gold et al. 1988). Moreover, exposure to cocaine-or amphetamine-related cues increases dopamine release within the NAc (DiCiano et al. 1998a,b;Fontana et al. 1993;Gratton and Wise 1994), alters NAc cell firing (Bowman et al. 1996;Giampoala et al. 1999), and induces conditioned increases in Fos-related protein within the caudal NAc (Franklin and Druhan 2000;Neisewander et al. 2000; although see Brown and Fibiger 1992). Together, these studies suggest that the NAc may be important for the expression of conditioned hyperactivity responses to psychostimulantpaired stimuli.Cortical and limbic regions that project to the NAc also may regulate conditioned responses to psychostimulant-related cues. Indeed, lesions or pharmacological manipulations of the medial prefrontal cortex (mPFC), the basolateral amygdala (Bl), and the ventral subiculum of the hippocampus (vSub) disrupt the stimulus control of operant drug-seeking responses measured in place-preference, conditioned reinforcement, or self-administration procedures (Brown and Fibiger 1993; Hiroi and White 1991; Phillips 1997, 1998;Isaac et al. 1989;Tzschentke and Schmidt 1998;Whitelaw et al...

show abstract

“…Recent studies have investigated the role of the PFC in classical (pavlovian) conditioning. For example, several studies have demonstrated that the medial PFC (mPFC) is intimately involved in the acquisition of pavlovian-conditioned autonomic responses (Buchanan and Powell, 1982;Buchanan et al, 1985;Neafsey, 1991, 1994;Powell et al, 1994), but other studies have shown that mPFC damage has no effect on simple somatomotor eyeblink (EB) classical conditioning (Buchanan and Powell, 1982;Weible et al, 2000;McLaughlin et al, 2002;Powell et al, 2005). However, it has also been reported that, under conditions that are less than optimal for learning to occur, such as during trace conditioning or partial reinforcement, mPFC lesions also impair EB conditioning (Kronforst-Collins and Disterhoft, 1998;Weible et al, 2000;McLaughlin et al 2002;Powell et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Post-Training Lesions of the Medial Prefrontal Cortex Interfere with Subsequent Performance of Trace Eyeblink Conditioning

Simon¹,

Knuckley²,

Churchwell³

et al. 2005

J. Neurosci.

View full text Add to dashboard Cite

Rabbits were trained on trace eyeblink (EB) conditioning until they reached a criterion of 10 consecutive EB conditioned responses (CRs). Electrolytic lesions were made in the medial prefrontal cortex (mPFC) centered on the prelimbic area (Brodmann's area 32), at five different intervals after training. These included immediately, 24 h, 1 and 2 weeks, and 1 month after training. Separate groups of animals received sham lesions at these same intervals after training. After a 2 week postoperative recovery period, all animals were retested for 3 d on trace conditioning, using the same parameters used during preoperative training. Mean EB conditioning performance deficits occurred in the animals with mPFC lesions compared with sham-lesioned animals on the first day of retesting in all five groups. However, by the second or third day of retesting, the rabbits with lesions were performing at a level that was comparable with that of sham animals. Rabbits that received more posterolateral lesions of the neocortex did not, however, show postoperative conditioning deficits. A comparison of percentage EB CRs of animals with postoperative training with that of animals that received mPFC lesions before training suggests that the mPFC post-training lesions produce damage to a retrieval process and not to a storage site or an acquisition process.

show abstract

Involvement of subdivisions of the medial prefrontal cortex in learned cardiac adjustments in rabbits.

Cited by 86 publications

References 41 publications

Effects of an electrolytic lesion of the prelimbic area on anxiety-related and cognitive tasks in the rat

Effects of an electrolytic lesion of the prelimbic area on anxiety-related and cognitive tasks in the rat

Involvement of the Nucleus Accumbens and Medial Prefrontal Cortex in the Expression of Conditioned Hyperactivity to a Cocaine-Associated Environment in Rats

Post-Training Lesions of the Medial Prefrontal Cortex Interfere with Subsequent Performance of Trace Eyeblink Conditioning

Contact Info

Product

Resources

About