Involvement of the Central Nervous System in Patients With Ovarian Carcinoma

Barker, Graham; Orledge, Jeffrey D.; Wiltshaw, E.

doi:10.1111/j.1471-0528.1981.tb01267.x

Cited by 54 publications

(32 citation statements)

References 2 publications

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“…Many patients, regardless of disease stage at presentation or at follow-up, do not routinely undergo brain imaging as part of the metastatic workup, given that some lesions remain asymptomatic. Several authors recently have called attention to the rising incidence of EOC metastatic to the brain [7,8]. Other recent studies have reported that the incidence of brain metastases has increased over time to 2%-4% [21].…”

Section: Incidencementioning

confidence: 99%

“…The Oncologist ® [7] or that cisplatin-based chemotherapy may contribute to the increased incidence of CNS metastases [21,53,62]. The integrity of the BBB is thought to limit delivery of large hydrophilic drugs to the site of brain metastases, thus presenting problems in choosing which agents and doses to use [53].…”

Section: Brain Metastases In Ovarian Cancermentioning

confidence: 99%

“…Brain metastases from EOC are rare and a late manifestation of the disease that occurs in patients with prolonged survival as a result of platinum-based chemotherapy. The incidence of brain metastases from EOC ranges from 0.29% to 5% [6][7][8]. Some reports have indicated that the rate is >5% and approaching 12% [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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Brain Metastases from Epithelial Ovarian Cancer: A Review of the Literature

2006

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Key Words. Brain metastases • Surgery • Stereotactic radiosurgery • Whole-brain radiotherapy • Chemotherapy Learning ObjectivesAfter completing this course, the reader will be able to:1. Select the appropriate treatment strategies for ovarian cancer patients with solitary brain metastases and extracranial disease.2. Describe the most important prognostic factors for ovarian cancer patients with brain metastases.3. List the diagnostic steps needed to establish the diagnosis of brain metastases in ovarian cancer patients.

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Section: Incidencementioning

confidence: 99%

Section: Brain Metastases In Ovarian Cancermentioning

confidence: 99%

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Brain Metastases from Epithelial Ovarian Cancer: A Review of the Literature

2006

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“…It is well known that almost all patients with EOC receive chemotherapy after initial diagnosis [27]. Some researchers have suggested that the increased incidence of brain metastasis in EOC is related to the effectiveness of chemotherapy [28], or that cisplatin-based chemotherapy may contribute to an increase in the incidence of CNS involvement [29,30], Thus, therapy of brain metastases with combination of surgery, WBRT and chemotherapy, or combination of surgery and WBRT or SRS (stereotactic radiosurgery)/GKRS (gamma-knife radiosurgery) yielded better survival results (median survival of 20, 17, and 18 months, resp.) than therapy of brain metastases with surgery alone, WBRT alone, chemotherapy alone, WBRT and chemotherapy, and no treatment (median survival of 6.7, 4.5, 7.5, 9.1, and 1.4 months, resp.).…”

Section: Discussionmentioning

confidence: 99%

Brain Metastases in a Patient with Ovarian Cancer

Kabulo¹

2017

IJNPT

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Abstrat: Brain metastases are associated with a poor prognosis. Depending on the patient's age, functional status, extent of systemic disease, and number of metastases. We report a case of 22-year-old female who presented with 2 months history of headache and vomiting and 1 day history of not communicating, neck stiffness, and generalized body weakness. Patient has been unwell for 2 months after she had collapsed at school 2 months prior complaining of severe headache, she allegedly stroked one month prior with left sided weakness. No history of trauma and seizures but had history of falling and remaining unconscious for unspecified period of time. No history of chronic illness and no family history of malignancies. Brain CT scan and MRI documented multiple lobulated irregularly enhancing brain parenchymal mass lesions of variable sizes, patient was taken to theatre and burr hole for brain tumor biopsy was done and specimen taken for histology which confirmed metastatic carcinoma and the tumor immunoreacted negatively to TTF1 and positively to CK7. Treatment of brain metastasis has evolved over the years from WBRT only for most patients to multimodal therapy including surgical resection, if feasible, followed by Whole brain Radiotherapy (WBRT) and/or chemotherapy.

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“…Ovarian primaries have accounted for about 1% of patients with brain metastases [I, 2]. Two current reports suggest that the incidence of this problem may be increasing [3,4]. The recent appearance of several such patients at NYU Medical Center prompted this review.…”

Section: Introductionmentioning

confidence: 99%

Brain metastases from ovarian cancer

et al. 1987

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Brain metastasis from ovarian carcinoma is a relatively rare phenomenon. At NYU Medical Center five patients were treated for this entity from 1982 to 1985. The stage at presentation ranged from stage I to stage III, and all patients had received or were receiving chemotherapy. Two patients had active disease elsewhere at diagnosis of brain metastasis, but three patients were otherwise NED. Three patients had solitary cerebellar disease, and two patients had multiple lesions. All patients were treated with whole brain radiotherapy to 3,000 cGy, with neurological improvement in three of the five patients. The central nervous system may need special consideration for prophylactic treatment in those patients with ovarian cancer who receive adjuvant chemotherapy.

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Involvement of the Central Nervous System in Patients With Ovarian Carcinoma

Abstract: In a survey of 430 patients with ovarian cancer, 4 developed brain deposits; 2 had received cis platin therapy.

Cited by 54 publications

References 2 publications

Brain Metastases from Epithelial Ovarian Cancer: A Review of the Literature

Brain Metastases from Epithelial Ovarian Cancer: A Review of the Literature

Brain Metastases in a Patient with Ovarian Cancer

Brain metastases from ovarian cancer

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