In a survey of 430 patients with ovarian cancer, 4 developed brain deposits; 2 had received cis platin therapy.

Summary Twenty‐two patients with primary carcinoma of the Fallopian tube treated at the Royal Marsden Hospital are reported. The age distribution, parity and variety of presentation of the disease were in accordance with previous reports in the literature. Overall survival at 5 years was 48% and the place of radiotherapy and chemotherapy in its management remains to be established.

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Sixty-one patients with FIGO stage III ovarian carcinoma and 30 patients with stage IV ovarian carcinoma were randomized to receive either high-dose cisplatin (100 mg/m2) or low-dose cisplatin (20 mg/m2) and chlorambucil. Overall response rates were similar in both arms, with 68% and 49% of stage III patients and 61% and 72% of stage IV patients responding to high-dose cisplatin and the combination, respectively. There was a strong trend for better survival in stage III (P less than .05) but not in stage IV patients treated with cisplatin alone. The toxicity suffered by patients treated with high-dose cisplatin was severe, and in 15 patients cisplatin therapy was stopped because of unacceptable toxicity.