Involvement of the endogenous nitric oxide signalling system in bradykinin receptor activation in rat submandibular salivary gland

Genaro, Ana Marı́a; Stranieri, Graciela; Borda, Enri

doi:10.1016/s0003-9969(00)00048-0

Cited by 10 publications

(8 citation statements)

References 16 publications

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“…Prostaglandins (PGs) are biologically active lipids synthesized from arachidonic acid, which, in turn, might generate NO (23). Some PGs and NO have been identified as mediators of inflammation (24,25).…”

mentioning

confidence: 99%

Cholinoceptor Modulation on Nitric Oxide Regulates Prostaglandin E2 and Metalloproteinase-3 Production in Experimentally Induced Inflammation of Rat Dental Pulp

Pita

Borda

Ganzinelli

et al. 2009

Journal of Endodontics

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confidence: 99%

Cholinoceptor Modulation on Nitric Oxide Regulates Prostaglandin E2 and Metalloproteinase-3 Production in Experimentally Induced Inflammation of Rat Dental Pulp

Pita

Borda

Ganzinelli

et al. 2009

Journal of Endodontics

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“…The action of bradykinin can be classified as: (i) a direct effect with bradykinin‐mediated Ca 2+ signaling after the activation of PLC‐ β ; and (ii) an indirect effect via bradykinin‐mediated PGE 2 or NO production after the activation of PLA 2 , COX, or NOS. The bradykinin‐mediated production of PGE 2 and subsequent physiological modulation is reported in rat submandibular gland cells and gingival fibroblasts . However, we could not find any PGE 2 ‐mediated Ca 2+ increase or cAMP production in HSG cells (Fig.…”

Section: Discussionmentioning

confidence: 54%

Human salivary gland cells express bradykinin receptors that modulate the expression of proinflammatory cytokines

Lee

Kim

Choi

et al. 2016

European J Oral Sciences

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Bradykinin is an important peptide modulator that affects the function of neurons and immune cells. However, there is no evidence of the bradykinin receptors and their functions in human salivary glands. Here we have identified and characterized bradykinin receptors on human submandibular gland cells. Both bradykinin B1 and B2 receptors are expressed on human submandibular gland cells, A253 cells, and HSG cells. Bradykinin increased the intracellular Ca concentration ([Ca ] ) in a concentration-dependent manner. Interestingly, a specific agonist of the B1 receptor did not have any effect on [Ca ] in HSG cells, whereas specific agonists of the B2 receptor had a Ca mobilizing effect. Furthermore, application of the B1 receptor antagonist, R715, did not alter the bradykinin-mediated increase in cytosolic Ca , whereas the B2 receptor antagonist, HOE140, showed a strong inhibitory effect, which implies that bradykinin B2 receptors are functional in modulating the concentration of cytosolic Ca . Bradykinin did not affect a carbachol-induced rise of [Ca ] and did not modulate translocation of aquaporin-5. However, bradykinin did promote the expression of proinflammatory cytokines, including tumor necrosis factor-α (TNF-α), implying the role of bradykinin in salivary gland inflammation. These data suggest that bradykinin receptors are involved in Ca signaling in human submandibular gland cells and serve a unique role, which is separate from that of other salivary gland G protein-coupled receptors.

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“…To complicate matters, it seems that mechanisms of NOS activation differ between exocrine tissues of the same species. Thus, bradykinin‐induced NO synthesis in rat submandibular salivary glands was found to be dependent on PLC activation and Ca 2+ influx (25), while it was previously reported that agonist‐induced release of Ca 2+ from intracellular stores activates NOS in submandibular and pancreatic acini (16). At present, however, it is unresolved whether these differences reflect the use of different methods or an actual difference in NOS regulation, which may even depend upon age and sex.…”

Section: Acinar Cells Synthesize Nitric Oxide Endogenouslymentioning

confidence: 96%

Nitric oxide signalling in salivary glands

Looms¹,

Tritsaris²,

Pedersen

et al. 2002

J Oral Pathology Medicine

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Nitric oxide (NO) plays multiple roles in both intracellular and extracellular signalling mechanisms with implications for health and disease. This review focuses on the role of NO signalling in salivary secretion. Attention will be paid primarily to endogenous NO production in acinar cells resulting from specific receptor stimulation and to NO-regulated Ca2+ homeostasis. Due to the fact that NO readily crosses membranes by simple diffusion, endogenous NO may play a physiological role in processes as diverse as modifying the secretory output, controlling blood supply to the gland, modulating transmitter output from nerve endings, participating in the host defence barrier, and affecting growth and differentiation of surrounding tissue. Furthermore, the role of NO in the pathogenesis of human oral diseases will be considered.

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Involvement of the endogenous nitric oxide signalling system in bradykinin receptor activation in rat submandibular salivary gland

Cited by 10 publications

References 16 publications

Cholinoceptor Modulation on Nitric Oxide Regulates Prostaglandin E2 and Metalloproteinase-3 Production in Experimentally Induced Inflammation of Rat Dental Pulp

Cholinoceptor Modulation on Nitric Oxide Regulates Prostaglandin E2 and Metalloproteinase-3 Production in Experimentally Induced Inflammation of Rat Dental Pulp

Human salivary gland cells express bradykinin receptors that modulate the expression of proinflammatory cytokines

Nitric oxide signalling in salivary glands

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