Involvement of the gabaergic, serotonergic and glucocorticoid mechanism in the anxiolytic-like effect of mastoparan-L

Franco, Octávio Luiz; Neves, Bruno J.; Morais, Álice Cristina B.; Neto, Jerônimo Raimundo de Oliveira; Cunha, Luíz Carlos da; Naves, Lara Marques; Pedrino, Gustavo Rodrigues; Costa, Élson Alves; Fajemiroye, James Oluwagbamigbe

doi:10.1016/j.npep.2020.102027

Cited by 6 publications

(3 citation statements)

References 60 publications

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“…After the behavioral testing procedures, plasma samples were collected by centrifuging whole blood samples at 10,000 g for 10 minutes. According to the previous study [ 26 ], the plasma samples were stored at -20°C until further analysis using high-performance liquid chromatography (HPLC). Briefly, dichloromethane (100 μL) was added to each plasma sample (100 μL) and vortexed for 30 seconds.…”

Section: Methodsmentioning

confidence: 99%

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A comparative analysis of depressive-like behavior: Exploring sex-related differences and insights

Rodrigues,

Moreira,

Prado

et al. 2023

PLoS ONE

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Profiling the variability related to the estrous cycle is essential for assessing depressive-like behavior and screening drugs. This study compares circulating plasma corticosterone levels [CORT] and behavioral alterations in mice exposed to sucrose preference, forced swimming, and tail suspension tests (SPT, FST, and TST, respectively). While SPT exposure did not significantly alter [CORT], FST and TST showed notable changes. Mice in the TST exhibited increased movement and decreased immobility time compared to FST, suggesting a lower likelihood of depressive-like behavior in male mice. Notably, during the proestrus phase, female mice displayed the highest tendency for depressive-like behavior and elevated [CORT], but similar response to antidepressants (imipramine and fluoxetine). The inherent stress of the FST and TST tasks appears to influence [CORT] as well as depressant and antidepressant effects. These comparisons provide valuable insights for further behavioral phenotyping, model sensitivity assessment, and deepen our neurobiological understanding of depression in the context of drug screening.

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Section: Methodsmentioning

confidence: 99%

“…The data were processed using LabSolutions software. The quantification procedure was adapted from previously described methods [ 26 , 27 ].…”

Section: Methodsmentioning

confidence: 99%

A comparative analysis of depressive-like behavior: Exploring sex-related differences and insights

Rodrigues,

Moreira,

Prado

et al. 2023

PLoS ONE

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show abstract

“…The anxiolytic-like effect of ML was attenuated by flumazenil and WAY100635 pretreatments. ML reduced the plasma corticosterone and lowered the scoring function at GABAA, 5-HT1A, corticotropin-releasing factor receptor subtype 1 (CRF1), and glucocorticoid receptors (GR) suggesting the involvement of GABAergic, serotonergic, and glucocorticoid mechanisms in its anxiolytic-like property (Silva et al, 2020a).…”

Section: Others Effects Of Mastoparansmentioning

confidence: 99%

Mastoparans: A Group of Multifunctional α-Helical Peptides With Promising Therapeutic Properties

Santana

Júnior

Fontes

et al. 2022

Front. Mol. Biosci.

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Biologically active peptides have been attracting increasing attention, whether to improve the understanding of their mechanisms of action or in the search for new therapeutic drugs. Wasp venoms have been explored as a remarkable source for these molecules. In this review, the main findings on the group of wasp linear cationic α-helical peptides called mastoparans were discussed. These compounds have a wide variety of biological effects, including mast cell degranulation, activation of protein G, phospholipase A2, C, and D activation, serotonin and insulin release, and antimicrobial, hemolytic, and anticancer activities, which could lead to the development of new therapeutic agents.

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Cell-Translocation Mechanisms of CPPs

Langel

2023

CPP, Cell-Penetrating Peptides

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Involvement of the gabaergic, serotonergic and glucocorticoid mechanism in the anxiolytic-like effect of mastoparan-L

Cited by 6 publications

References 60 publications

A comparative analysis of depressive-like behavior: Exploring sex-related differences and insights

A comparative analysis of depressive-like behavior: Exploring sex-related differences and insights

Mastoparans: A Group of Multifunctional α-Helical Peptides With Promising Therapeutic Properties

Cell-Translocation Mechanisms of CPPs

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