Involvement of the PI3K/Akt signal pathway in the hypoglycemic effects of tea polysaccharides on diabetic mice

Li, Shuqin; Chen, Hạixia; Wang, Jia; Wang, Xiuming; Hu, Bo; Lv, Fu-Ning

doi:10.1016/j.ijbiomac.2015.09.037

Cited by 123 publications

(85 citation statements)

References 30 publications

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“…55 A change in the PI3K-Akt signaling pathway would not only affect 1 cell but multiple cell organizations. Using reverse transcription-polymerase chain reaction analysis, Yang et al found that the PI3K-Akt signaling pathway changed in liver, skeletal muscle, and adipose tissues, and all gene expression levels significantly decreased.…”

Section: The Pi3k-akt Signaling Pathway and Irmentioning

confidence: 99%

Role of the PI3K-Akt Signaling Pathway in the Pathogenesis of Polycystic Ovary Syndrome

et al. 2017

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This review aimed to focus on the recent progress of the understanding of the role of phosphatidylinositol 3-kinase (PI3K) in polycystic ovary syndrome (PCOS). In recent years, it has been increasingly recognized that PI3K plays an important role in PCOS whose pathogenesis is unclear. However, research continues into revealing the details of how PI3Ks are involved in developing PCOS. Previous studies have shown that activation of the PI3K-protein kinase B (Akt) signaling pathway has important effects on insulin resistance and endometrial cancer. Knowledge of the action of PI3K in PCOS might provide valuable information to further validate the pathogenesis of PCOS and suggest new methods of treatment.

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Section: The Pi3k-akt Signaling Pathway and Irmentioning

confidence: 99%

Role of the PI3K-Akt Signaling Pathway in the Pathogenesis of Polycystic Ovary Syndrome

et al. 2017

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“…The other hypoglycaemic mechanism of PTPS may involve the regulation of PIP3/Akt signal pathway. PTPS was founded to enhance the expression of PI3Kp85/p-Akt/GLUT4 in type 2 Diabetes mellitus mice (Li et al, 2015). The intake in those Diabetes mellitus mice was administered orally with PTPS being dissolved in normal saline at the dose of 200, 400, 800 mg kg À1 body weight per day for 28 days.…”

Section: Discussionmentioning

confidence: 99%

Systematic review and meta‐analysis of anti‐hyperglycaemic effects of Pu‐erh tea

Lin

Lee²,

Yen

et al. 2018

Int J of Food Sci Tech

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Summary Pu‐erh tea was presumed to have anti‐hyperglycaemic effects with limited evidence. This study uses meta‐analysis to investigate anti‐hyperglycaemic effect of Pu‐erh tea. Five English databases and three Chinese ones were systematically searched up to July 31, 2018. Those databases were searched to identify studies containing keywords of ‘Pu‐erh’, ‘Pu'er’, ‘blood sugar’, ‘blood glucose’ and ‘hyperglycaemia’. RevMan 5 and Stata were then utilized to conduct meta‐analysis. Systematic reviews collected two mice studies with sixteen records for meta‐analysis. Meta‐analysis results showed that Pu‐erh tea has significant anti‐hyperglycaemic effect on mice. Pooled weight mean difference of blood sugar on mice studies were 71 and 116 mg dL−1 at 21st day and 28th day respectively. Meta‐regression disclosed over a longer intervention period showed that Pu‐erh tea can reduce fasting blood glucose. Secondly, a higher dose of Pu‐erh is shown to lower fasting blood glucose more significantly.

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“…Particularly, diabetes was the most study disease in in vitro studies (n = 16) and obesity in in vivo studies (n = 20), and clinical trials (n = 6). In several in vitro and in vivo studies, the effect of extracts and isolated compounds of Camellia sinensis on two different pathologies were studied in the same research work [9][10][11][12][13][14][15][16]. This review is divided into six sections, based on the pathologies, diabetes, hypercholesterolemia, hypertension, metabolic syndrome, obesity, and osteoporosis.…”

Section: Pharmacological Activity Description Of the Datamentioning

confidence: 99%

“…In addition, there are several in vitro studies with cellular models, mouse 3T3-L1 pre/adipocytes and HepG2 cell lines being the most common. Moreover, for in vivo studies, preclinical diabetic animal models (Kunming mice, Sprague-Dawley, and Wistar rats) commonly used to investigate the anti-diabetic properties of tea are streptozotocin and alloxan-induced diabetic animals [10,16,22,23]. Furthermore, the nematode Caenorhabditis elegans has been also investigated as diabetic model [24].…”

Section: Camellia Sinensis and Diabetesmentioning

confidence: 99%

“…Another signal transduction pathway on which tea polysaccharides from green tea (200, 400, and 800 mg/kg b.w. per day for 4 weeks) have been shown to act is the PI3K/Akt signal pathway which stimulates GLUT 4 translocation and activation [10]. Moreover, epigallocatechin gallate promoted glucose uptake by increasing GLUT4 translocation via PI3K/AKT in L6 skeletal muscle cells [15].…”

Section: Camellia Sinensis and Diabetesmentioning

confidence: 99%

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The Pharmacological Activity of Camellia sinensis (L.) Kuntze on Metabolic and Endocrine Disorders: A Systematic Review

et al. 2020

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Tea made from Camellia sinensis leaves is one of the most consumed beverages worldwide. This systematic review aims to update Camellia sinensis pharmacological activity on metabolic and endocrine disorders. Inclusion criteria were preclinical and clinical studies of tea extracts and isolated compounds on osteoporosis, hypertension, diabetes, metabolic syndrome, hypercholesterolemia, and obesity written in English between 2014 and 2019 and published in Pubmed, Science Direct, and Scopus. From a total of 1384 studies, 80 reports met inclusion criteria. Most papers were published in 2015 (29.3%) and 2017 (20.6%), conducted in China (28.75%), US (12.5%), and South Korea (10%) and carried out with extracts (67.5%, especially green tea) and isolated compounds (41.25%, especially epigallocatechin gallate). Most pharmacological studies were in vitro and in vivo studies focused on diabetes and obesity. Clinical trials, although they have demonstrated promising results, are very limited. Future research should be aimed at providing more clinical evidence on less studied pathologies such as osteoporosis, hypertension, and metabolic syndrome. Given the close relationship among all endocrine disorders, it would be of interest to find a standard dose of tea or their bioactive constituents that would be beneficial for all of them.

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Involvement of the PI3K/Akt signal pathway in the hypoglycemic effects of tea polysaccharides on diabetic mice

Cited by 123 publications

References 30 publications

Role of the PI3K-Akt Signaling Pathway in the Pathogenesis of Polycystic Ovary Syndrome

Role of the PI3K-Akt Signaling Pathway in the Pathogenesis of Polycystic Ovary Syndrome

Systematic review and meta‐analysis of anti‐hyperglycaemic effects of Pu‐erh tea

The Pharmacological Activity of Camellia sinensis (L.) Kuntze on Metabolic and Endocrine Disorders: A Systematic Review

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