Involvement of β-adrenoceptors in the regulation of luteal function in cattle

Kotwica, J.; Skarzynski, Dariusz J.; Jaroszewski, Jerzy Jan

doi:10.1016/0007-1935(91)90043-m

Cited by 22 publications

(16 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings suggest that constant β-adrenergic stimulation plays an important role in the regulation of bovine CL function. The importance of this stimulation was confirmed by our finding that administration of propranolol (a β-adrenergic blocker) decreased basal P4 production by 40% [30]. This result is consistent with the fact that β-adrenergic stimulation affects 3β-hydroxysteroid dehydrogenase activity [20].…”

Section: Noradrenaline As a Luteotropic Factorsupporting

confidence: 84%

“…It has been demonstrated that PGF 2α [22], somatotropin [23] and some growth factors [24][25][26] increased OT secretion by microdialysed CL in vitro, and that both noradrenaline (NA) and PGF2α stimulated production and output of OT by incubated bovine luteal cells [27][28][29] and slices [20]. It has also been shown that administration of PGF 2α and NA caused the release of OT from bovine CL in vivo [30][31][32].…”

Section: Luteotropic Role Of Luteal Oxytocinmentioning

confidence: 99%

See 1 more Smart Citation

Luteotropic Mechanisms in the Bovine Corpus Luteum: Role of Oxytocin, Prostaglandin F2 α, Progesterone and Noradrenaline

Skarżyński

Jaroszewski

Okuda

2001

Journal of Reproduction and Development

View full text Add to dashboard Cite

Abstract. The main function of the corpus luteum (CL) is production of progesterone (P4). Adequate luteal function to secrete P4 is crucial for determining the physiological duration of the estrous cycle and for achieving a successful pregnancy. The bovine CL grows very fast and regresses within two days at luteolysis. The mechanism controlling the development and secretory function of the bovine CL may involve many factors that are produced both within and outside the CL. Some of these regulators seem to be prostaglandins (PGs), oxytocin (OT) and adrenergic factors such as noradrenaline (NA). Recently, there has been some evidence that P4 acts within the bovine CL as an autocrine and/or paracrine regulator. Each of these factors may act on the CL independently or may modify the actions of others. The purpose of this paper is to review and discuss the possible roles of OT, PGs, P4 and NA as luteotropic auto/paracrine regulators in the bovine CL. Furthermore, intraluteal mechanisms controlling the sensitivity of the CL to extragonadal PGF2α are discussed.

show abstract

Section: Noradrenaline As a Luteotropic Factorsupporting

confidence: 84%

Section: Luteotropic Role Of Luteal Oxytocinmentioning

confidence: 99%

Luteotropic Mechanisms in the Bovine Corpus Luteum: Role of Oxytocin, Prostaglandin F2 α, Progesterone and Noradrenaline

Skarżyński

Jaroszewski

Okuda

2001

Journal of Reproduction and Development

View full text Add to dashboard Cite

show abstract

“…A similar effect has also been found in the human endometrium, in which increasing serum P 4 concentrations cause PGR protein expression to decrease during the first half of the estrous cycle [29]. The increase in P 4 synthesis in the bovine CL is the highest on Days 6 to 12 of the estrous cycle [30,31]. Therefore, the activity of this hormone may lead to a reduction in the amount of PGR mRNA in the cow endometrium on Days 6 to 10 of the estrous cycle [8].…”

Section: Discussionsupporting

confidence: 56%

Onapristone (ZK299) and mifepristone (RU486) regulate the messenger RNA and protein expression levels of the progesterone receptor isoforms A and B in the bovine endometrium

2015

View full text Add to dashboard Cite

“…A diminution in this hormone concentration was previously observed after pharmacological blockade of ovarian β-receptors in heifers in the middle luteal phase (Kotwica et al, 1991) and in gilts after surgical denervation of ovaries during the early luteal phase (Jana et al, 2005). In the present experiment, the most pronounced decrease in the secretion of E 1 , E 2 and LH was observed in gilts with denervated ovaries during the perioestrous period.…”

Section: Discussionmentioning

confidence: 70%

Surgical denervation of porcine ovaries during the middle luteal phase of the oestrous cycle changes their morphology and steroidogenic activity

Jana

Dzienis

Wojtkiewicz

et al. 2007

Acta Veterinaria Hungarica

View full text Add to dashboard Cite

Changes in both the morphology and the steroidogenic activity of porcine ovaries denervated surgically on day 12 of the oestrous cycle were studied. Neurectomy of the plexus and the superior ovarian nerves caused a dramatic reduction in the number (or even a disappearance) of dopamine-β-hydroxylaseand/or neuropeptide tyrosine-immunoreactive nerve terminals. On day 20 of the subsequent oestrous cycle, the number of small follicles increased (P < 0.01) and that of large follicles decreased (P < 0.05) in the denervated ovaries, as compared to the controls. Neurectomy led to a decrease in the level of progesterone (P 4 ; P < 0.001) and androstenedione (A 4 ; P < 0.01) in the fluid from small follicles, A 4 (P < 0.001) and testosterone (T; P < 0.05) in the fluid from medium-sized follicles, as well as in the content of all these steroids in the fluid from large-sized follicles (P < 0.001 for P 4 and P < 0.05 for A 4 and T). Denervation also caused a decrease in the content of A 4 (P < 0.01) and T (P < 0.001) in the wall of follicles. Neurectomy resulted in a significant increase in the immunoexpression of cholesterol side-chain cleavage cytochrome P450 in the follicles and a decrease of 3β-hydroxysteroid dehydrogenase. After denervation, plasma levels of LH, P 4 , A 4 , T, oestrone and oestradiol-17β were lower (P < 0.05-0.001) on the particular days of the study than in the control group. Our data revealed that the denervation of ovaries during the middle luteal phase of the oestrous cycle in gilts caused distinct changes in both the morphology and the steroidogenic activity of the organ, confirming an important role of the peripheral nervous system in the control of the gonad in this species. Acta Veterinaria Hungarica 55, 2007It is well known that mammalian ovaries are fairly innervated by fibres belonging to the adrenergic, cholinergic and/or peptidergic subsets of the autonomic and sensory systems. Ovarian function is thus regulated by both hormonal and neuronal input operating in concert to control follicular development, steroidogenesis and ovulation. Numerous studies performed on laboratory animals showed that the effects of gonad denervation are dependent not only on species and age of animals, but also on the experimental procedure. For instance, the blockade of ovarian innervation development in neonatal rats resulted in limited follicular growth, delayed puberty, decreased oestradiol-17β (E 2 ) secretion and marked irregularities of the oestrous cycles (Lara et al., 1990a). Conversely, chemical sympathectomy induced by guanethidine administration to newborn guinea pigs caused ovulation (Riboni et al., 1997). Although bilateral sectioning of the superior ovarian nerve (SON) in adult rats did not affect ovulation (Chávez et al., 1991), it was able to decrease the plasma levels of progesterone (P 4 ) and E 2 (Erskine and Weaver, 1988). On the other hand, an inhibition of this process occurred in adult guinea pigs exposed to guanethidine (Trujillo and Riboni, 2002). Moreover, it was indicated by Luna et al. ...

show abstract

Involvement of β-adrenoceptors in the regulation of luteal function in cattle

Cited by 22 publications

References 30 publications

Luteotropic Mechanisms in the Bovine Corpus Luteum: Role of Oxytocin, Prostaglandin F<sub>2</sub> <sub>α</sub>, Progesterone and Noradrenaline

Luteotropic Mechanisms in the Bovine Corpus Luteum: Role of Oxytocin, Prostaglandin F<sub>2</sub> <sub>α</sub>, Progesterone and Noradrenaline

Onapristone (ZK299) and mifepristone (RU486) regulate the messenger RNA and protein expression levels of the progesterone receptor isoforms A and B in the bovine endometrium

Surgical denervation of porcine ovaries during the middle luteal phase of the oestrous cycle changes their morphology and steroidogenic activity

Contact Info

Product

Resources

About

Involvement of β-adrenoceptors in the regulation of luteal function in cattle

Cited by 22 publications

References 30 publications

Luteotropic Mechanisms in the Bovine Corpus Luteum: Role of Oxytocin, Prostaglandin F<sub>2</sub> <sub>&alpha;</sub>, Progesterone and Noradrenaline

Luteotropic Mechanisms in the Bovine Corpus Luteum: Role of Oxytocin, Prostaglandin F<sub>2</sub> <sub>&alpha;</sub>, Progesterone and Noradrenaline

Onapristone (ZK299) and mifepristone (RU486) regulate the messenger RNA and protein expression levels of the progesterone receptor isoforms A and B in the bovine endometrium

Surgical denervation of porcine ovaries during the middle luteal phase of the oestrous cycle changes their morphology and steroidogenic activity

Contact Info

Product

Resources

About

Luteotropic Mechanisms in the Bovine Corpus Luteum: Role of Oxytocin, Prostaglandin F<sub>2</sub> <sub>α</sub>, Progesterone and Noradrenaline

Luteotropic Mechanisms in the Bovine Corpus Luteum: Role of Oxytocin, Prostaglandin F<sub>2</sub> <sub>α</sub>, Progesterone and Noradrenaline