Involving the cerebellum in cocaine-induced memory: pattern of cFos expression in mice trained to acquire conditioned preference for cocaine

Carbó-Gas, Maria; Vázquez-Sanromán, Dolores; Aguirre-Manzo, Luisa; Coria-Ávila, Genaro A.; Manzo, Jorge; Sanchis‐Segura, Carles; Miquel, Marta

doi:10.1111/adb.12042

Cited by 44 publications

(58 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a matter of fact, the presence of dopaminergic synaptic components in the cerebellum of primates and rodents has been repeatedly demonstrated (Melchitzky and Lewis, 2000;Carbo-Gas et al, 2014a). This finding is consistent with the observed reciprocal connections between the cerebellum and the ventral tegmental area (VTA), the main source of dopamine in the mesocorticolimbic system (Ikai et al, 1992).…”

Section: Introductionsupporting

confidence: 57%

“…Therefore, a plausible explanation for the cerebellar response during cue-elicited craving might be the previously identified role of the cerebellum in prediction (Carbo-Gas et al, 2014a;Miquel el al., 2016). This possibility is supported by theories on cerebellar function that involve this part of the brain in a generalized prediction process (Courchesne and Allen, 1997;D'Angelo and Casali, 2013).…”

Section: The Cerebellum's Role: Craving or Prediction?mentioning

confidence: 98%

“…Additionally, there are several reports which indicate that the cerebellar vermis is connected with the dopamine circuitry. Studies in rodents (Carbo-Gas et al, 2014a, Ikai et al, 1992, monkeys (Melchitzky and Lewis, 2000), and humans (Anderson et al, 2006) are indicative of dopaminergic synaptic components and transmission in the cerebellum across species. This evidence is accompanied by the fact that the cerebellar vermis has demonstrated to be linked to limbic and reward-related structures, such as amygdala (Sang et al, 2012;Yu et al, 2016), hippocampus (Sang et al, 2012), as well as ventral tegmental area (Rogers et al, 2011;Etkin et al, 2009;Kline et al, 2016;Kwon et al, 2014) and both dorsal (Tomasi and Volkow, 2011) ventral striatal zones (Cauda et al, 2011;Koehler et al, 2013).…”

Section: The Cerebellum's Role: Craving or Prediction?mentioning

confidence: 99%

See 2 more Smart Citations

The cerebellum in drug craving

Moreno-Rius

Miquel

2017

Drug and Alcohol Dependence

Self Cite

View full text Add to dashboard Cite

Craving has been considered one of the core features of addiction. It can be defined as the urge or conscious desire to use a drug elicited by the drug itself, drug-associated cues or stressors. Craving plays a major role in relapse, even after prolonged periods of abstinence, as well as in the maintenance of drug seeking in non-abstinent addicts. The circuitry of craving includes medial parts of the prefrontal cortex, ventral striatal zones, ventral tegmental area, ventral pallidum, and limbic regions. Interestingly, the cerebellum shows reciprocal loops with many of these areas. The cerebellum has been linked traditionally to motor functions but increasing evidence indicates that this part of the brain is also involved in functions related to cognition, prediction, learning, and memory. Moreover, the functional neuroimaging studies that have addressed the study of craving in humans repeatedly demonstrate cerebellar activation when craving is elicited by the presentation of drug-related cues. However, the role of cerebellar activity in these craving episodes remains unknown. Therefore, the main goal of this review is to provide a brief update on craving studies and the traditional neural basis of this phenomenon, and then discuss and propose a hypothesis for the function of the cerebellum in craving episodes.

show abstract

Section: Introductionsupporting

confidence: 57%

Section: The Cerebellum's Role: Craving or Prediction?mentioning

confidence: 98%

Section: The Cerebellum's Role: Craving or Prediction?mentioning

confidence: 99%

See 1 more Smart Citation

The cerebellum in drug craving

Moreno-Rius

Miquel

2017

Drug and Alcohol Dependence

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently, we have shown that conditioned preference towards an odour associated with cocaine was directly correlated with cFOS expression in cells at the dorsal region of the granule cell layer of the cerebellar vermis [21]. These findings are coincident with those of some clinical reports.…”

Section: Introductionsupporting

confidence: 83%

Involvement of the cerebellum in cocaine-induced memory

Gas¹

View full text Add to dashboard Cite

PREFACEBecause of its role in drug-seeking, consumption and addictive behavior, there is a growing interest in identifying the neural circuits and molecular mechanisms underlying the formation, maintenance and retrieval of drug-induced memories. However, very few studies have focused on brain areas beyond the corticostriatal-limbic circuitry. Despite the growing evidence confirming the involvement of the cerebellum in drug-induced alterations, this structure has been traditionally disregarded in the addiction field Miquel et al, 2016).The general aim of the present research is to address wether the cerebellum is part of the neuronal systems that sustains the plasticity mechanisms underlying drug-induced conditioned memories. We have focused our research in an attempt to clarify if the cerebellum is involved in the acquisition and storage of drug memories. Although previous scattered reports described the involvement of the cerebellum in drug-related memories, this is the first attempt to address a detailed functional analysis about the issue.The present doctoral thesis contains three different chapters. The first two include two investigations that have been already published (Carbo-gas et al., 2014ab), and the third is one currently under revision. In the first chapter, Involving the cerebellum in cocaineinduced memory: pattern of cFos expression in mice trained to acquire conditioned preference for cocaine, we explored the pattern of neuronal activation as revealed by cFos immunoreactivity of mice trained to develop conditioned preference for an olfactory stimulus paired with cocaine. In the second one, entitled Cerebellar hallmarks of conditioned preference for cocaine, we used the same behavioral task of the first study in order to further extend the description of cFos expression patterns in cerebellar circuitry, including now the major inputs and one of the output nuclei of the cerebellum. 9In the last chapter, Cerebellar perineuronal nets in cocaine-induced Pavlovian memory:site does matter, we accomplished a broad analysis of perineuronal nets (PNNs) expression of cerebellar vermis. First, we analysed an outbred mouse strain trained to acquire preference for olfactory stimuli associated with cocaine. Second, α6Cre-Cacna1a mice were used to test if a reduction in the glutamate release of parallel fibres to Purkinje dendrites would alter the acquisition of cocainepreference conditioning and the expression of PNNs in the cerebellum.After the presentation of the chapters, there is a section where summarised findings, strengths and pitfalls as well as future directions are provided. References can be also found at the end of the present document.Finally, we conclude this thesis with an appendix. This document is formed by research not finished yet, but that may be of great relevance to understand the role of the cerebellum in addictive disorders. In that appendix, we explored the effect of a focal lesion in the dorsal cerebellar cortex (Lobule VIII) on the acquisition of food selfadministration. This researc...

show abstract

“…Nevertheless, it is a fact that addictive drugs, in a certain dose range, have the ability to elicit this approach response towards the stimulus that have been paired with (Carbo-Gas et al, 2014;Braida et al, 2004). MDPV also shows this effect.…”

Section: Resultsmentioning

confidence: 99%