Iodine and Thyroid Function Status, and Anti-thyroid Peroxidase Antibody among Pregnant Women in Eastern Nepal

Chaudhary, Lalit Narayan; Khatiwada, Saroj; Gelal, Basanta; Gautam, Swotantra; Lamsal, Madhab; Pokharel, Hanoon P; Baral, Nirmal

doi:10.3126/jnhrc.v15i2.18182

Cited by 18 publications

(22 citation statements)

References 18 publications

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“…A 41% prevalence of subclinical or overt hypothyroidism in pregnant women has been reported in a hospital based study in Western Nepal [33]. Another study on iodine deficiency and hypothyroidism amongst pregnant women found 3.2% of the cases positive for antibodies to thyroid peroxidase and 18.5% of the women to have inadequate levels (<150 µg/L) of iodine [34]. In a study of children diagnosed with congenital hypothyroidism [9], thyroid agenesis, dyshormogenesis and ectopic thyroid were the most common causes of low thyroid hormones.…”

Section: 1tshmentioning

confidence: 89%

Newborn Screening for Selected Disorders in Nepal: A Pilot Study

Pandey

Joshi

Rajbhandari

et al. 2019

IJNS

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The prevalence of metabolic disorders in Nepal is yet unknown, although many case reports occur in literature. Heel-prick blood samples from newborns were collected on Dried Blood Spot (DBS) collection cards and tested through Tandem Mass Spectroscopy and fluorescence assays for disorders included in the Swiss neonatal screening program; two cases of hypothyroidism and one case of cystic fibrosis were identified. Thyroid stimulating hormone (TSH), immuoreactive trypsinogen (IRT), hydroxyprogesterone (OHP), tyrosine (Tyr), and octanoylcarnitine (C8) showed significant differences with gestation age. Most of the parameters were positively correlated with each other except galactose, galactose 1 phosphate uridyl transferase (GALT), and biotinidase. First and ninety-ninth percentiles in the Nepalese newborns were found to be different when compared with the Swiss newborns. Congenital hypothyroidism and cystic fibrosis are candidates to be considered for a newborn screening program in Nepal. Differences between the Nepalese and Swiss newborns in parametric values that change with gestation age can be attributed to a higher survival rate of pre-term babies in Switzerland. Others could be explained in part by early and exclusive breastfeeding in Nepalese newborns.

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Section: 1tshmentioning

confidence: 89%

Newborn Screening for Selected Disorders in Nepal: A Pilot Study

Pandey

Joshi

Rajbhandari

et al. 2019

IJNS

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“…LSCS is significantly higher in hypothyroids than euthyroids (48.5% versus 18.8%, p value equal to 19 In comparison to other studies done in different part of world prevalence of hypothyroidism is very high in Nepal. Nutritional factor may be one of the causes for this as there is high prevalance of iodine deficiency hypothyroidism in Nepal.…”

Section: Resultsmentioning

confidence: 52%

“…Studies from Nepal shows very high prevalence of hypothyroidism. 18,19 By treating hypothyroidism in early pregnancy, we can reduce the fetal and maternal mortality and come up with excellent fetal maternal outcome.…”

Section: Resultsmentioning

confidence: 99%

Screening of Thyroid Disorder among Pregnant Ladies in a Tertiary Hospital of Nepal

Shrestha

Adhikari

2019

Nep. Med. Coll. J.

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Thyroid disorders (TD) are the second most common endocrine disorders seen in pregnancy. Many physiological changes in pregnancy lead to hypothyroidism in pregnancy. Hypothyroid in pregnancy is associated with many adverse maternal and fetal outcomes. Objective of this study was to find the prevalence of TD in pregnancy in Nepal Medical College Teaching Hospital (NMCTH), Antithyroid Peroxidase Antibody (TPO-Ab) positive cases with hypothyroidism and to evaluate maternal fetal outcome in hypothyroid pregnancies. This was a prospective hospital based observational study. The study was done in Department of Obstetrics and Gynecology, NMCTH from August 2018 to July 2019. Among 420 pregnant ladies 71.0% were euthyroid, 25.7% were hypothyroid (25.2%of subclinical and 0.5% overt), 3.3% were hyperthyroid (0.7% of overt) and 6.4% were TPO-Abpositive with hypothyroidism. Inspite of treatment, Gestational hypertention, Pre-eclampsea and LSCS is significantly high in hypothyroid pregnancy than euthyroid pregnancy. High prevalence of hypothyroidism in this study necessitates universal screening of TD at first trimester of pregnancy.

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“…The median thyroglobulin level in the children with insufficient UIC was 17.5 ng/mL. Our previous study among pregnant women of eastern Nepal reported median Tg of 6.5 ng/mL [17]. Thyroglobulin increment in plasma is also seen with thyroid mass, inflammation and hyperactivity of TSH [18].…”

Section: Main Textmentioning

confidence: 81%

“…In addition, there are other causative factors for thyroid disorders such as thyroid autoimmunity which might have been missed from this subgroup [17]. Thyroid function is said to be impaired in both the condition of iodine deficiency and excess [1].…”

Section: Main Textmentioning

confidence: 99%

Thyroid function and thyroglobulin level in iodine deficient children of eastern Nepal

Kunwar¹,

Khatiwada²,

Gelal³

et al. 2020

Preprint

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Objective: Both iodine deficiency and excess can negatively impact thyroid function. The present study was conducted to assess iodine nutrition among children and thyroid function in iodine deficient children. Results: A total of 1012 school aged children (6-14 years) from several schools of Udayapur district were enrolled initially for the assessment of urinary iodine concentration (UIC). Blood samples (n=83) were collected from a subgroup of children who had UIC<100 µg/L to measure serum thyroglobulin (Tg), thyroid stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4). Serum UIC was measured by ammonium persulfate digestion method and Tg, TSH, fT4 and fT3 were measured by ELISA kits from Diametra Company. The prevalence of insufficient UIC (UIC<100 µg/L) was 11.1% in school children’s of Udayapur district. The median UIC was 236 µg/L. The mean fT3, fT4 and TSH among children with insufficient UIC were 2.55±0.43 pg/mL, 0.96±0.28 ng/dL and 3.60±1.44 mIU/L respectively. The Median Tg was 17.5 ng/mL. Overt hypothyroidism and subclinical hypothyroidism was seen in 6% and 3.6% cases with UIC<100 µg/L respectively.

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Iodine and Thyroid Function Status, and Anti-thyroid Peroxidase Antibody among Pregnant Women in Eastern Nepal

Abstract: INTRODUCTION

Cited by 18 publications

References 18 publications

Newborn Screening for Selected Disorders in Nepal: A Pilot Study

Newborn Screening for Selected Disorders in Nepal: A Pilot Study

Screening of Thyroid Disorder among Pregnant Ladies in a Tertiary Hospital of Nepal

Thyroid function and thyroglobulin level in iodine deficient children of eastern Nepal

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