Iodine and zinc, but not selenium and copper, deficiency exists in a male Turkish population with endemic goiter

Özata, Metịn; Salk, Melvin R.; Aydın, Ahmet; Sayın, Selim; Öktenli, Çağatay; Beyhan, Zeynel; Işimer, A.; Ozdemír, I. Caglayan

doi:10.1007/bf02783873

Cited by 29 publications

(20 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A sex difference is in agreement with the results of the study by Derumeaux et al (11). Furthermore, Ozata et al (26) did not find a difference in serum selenium between men with goiter and men without goiter. The sex difference could explain part of the inconsistency in the results from different studies.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency

Rasmussen¹,

Schomburg²,

Köhrle³

et al. 2011

European Journal of Endocrinology

117

View full text Add to dashboard Cite

Objective: The objective was to study the associations between serum selenium concentration and thyroid volume, as well as the association between serum selenium concentration and risk for an enlarged thyroid gland in an area with mild iodine deficiency before and after iodine fortification was introduced. Another objective was to examine the association between serum selenium concentration and prevalence of thyroid nodules. Design: Cross-sectional study. Methods: We studied participants of two similar cross-sectional studies carried out before (1997-1998, nZ405) and after (2004)(2005), nZ400) introduction of iodine fortification. Serum selenium concentration and urinary iodine were measured, and the thyroid gland was examined by ultrasonography in the same subjects. Associations between serum selenium concentration and thyroid parameters were examined in multiple linear regression models or logistic regression models. Results: Serum selenium concentration was found to be significantly, negatively associated with thyroid volume (PZ0.006), and a low selenium status significantly increased the risk for thyroid enlargement (PZ0.007). Furthermore, low serum selenium status had a tendency to increase the risk for development of multiple nodules (PZ0.087). Conclusions: Low serum selenium concentration was associated with a larger thyroid volume and a higher prevalence of thyroid enlargement.

show abstract

Section: Discussionsupporting

confidence: 90%

“…Results from other studies examining the relation between selenium and thyroid volume differ (8)(9)(10)(23)(24)(25)(26)(27)(28). However, the results from our study are in line with results from the largest study carried out so far regarding selenium and thyroid volume (11).…”

Section: Discussionsupporting

confidence: 90%

Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency

Rasmussen¹,

Schomburg²,

Köhrle³

et al. 2011

European Journal of Endocrinology

117

View full text Add to dashboard Cite

show abstract

“…Although iodine deficiency is not very severe in general, it may rise to a significant level depending on the area [24]. Iodine status of our country has improved thanks to iodine prophylaxis program initiated in 1999 [25]. We assume that the high incidence of TA and TMNG is related to the introduction of iodine salt supplementation in our iodinedeficient areas, as already reported [26][27][28].…”

Section: Discussionmentioning

confidence: 60%

Prevalence of incidental thyroid cancer and its ultrasonographic features in subcentimeter thyroid nodules of patients with hyperthyroidism

Berker

Işık

Özuğuz

et al. 2010

Endocr

View full text Add to dashboard Cite

In patients, who undergo surgery for hyperthyroidism, many cases of incidental thyroid cancer (ITC) have been detected. In the literature, there is no study about ITC in subcentimeter nodules in these patients. We performed this study to determine the frequency of ITC in subcentimeter nodules and ultrasonographic features that can predict malignancy in the patients with hyperthyroidism. We retrospectively reviewed our database about 3114 patients, who underwent thyroidectomy in our hospital. Among 869 patients (27.9%), who were operated because of hyperthyroidism, we enrolled 337 patients, who underwent total thyroidectomy and had subcentimeter nodule [59 Graves’ disease (GD) 98 subcentimeter nodule; 278 toxic multinodular goitre (TMNG), 359 subcentimeter nodule], in this study. Twenty-five nodules with ITC and 432 benign nodules have been detected and compared for ultrasonographic (US) features. Incidental thyroid cancer detection ratio was 5.4% [10.2% (10/98) in subcentimeter thyroid nodules in individuals with GD, and 4.1% (15/359) in individuals with TMNG, P = 0.018)]. Significant differences have been observed between the groups in terms of microcalcification in US examination of malign and benign subcentimeter thyroid nodules and the ratio of anterioposterior diameter to transverse diameter (A/T) ≥1 [(OR = 5.172; 95% CI: 1.495–17.886, P = 0.015), and (OR = 5.930; 95% CI: 1.531–22.971, P = 0.007), respectively]. We detected a higher incidence of ITC in subcentimeter thyroid nodules in GD compared to TMNG. US examination of subcentimeter nodules in hyperthyroid individuals has indicated that microcalcification and ratio of A/T ≥1 are the parameters that predict malignancy.

show abstract

“…In particular, the disruption of oxidant-antioxidant balance and impairment of immune function are considered the possible factors in a wide range of pathological conditions, including different thyroid disorders, e.g., Hashimoto disease, endemic goiter, and different cancers of the gland [10][11][12]. The baseline levels of Se, Cu, and Zn may have clinical relevance for supplementation efficacy [13].…”

mentioning

confidence: 99%

Thyroid Disorders—Assessments of Trace Elements, Clinical, and Laboratory Parameters

Przybylik-Mazurek

Zagrodzki

Kuźniarz-Rymarz

et al. 2010

Biol Trace Elem Res

View full text Add to dashboard Cite

The trace elements studied in this work (Se, Cu, Zn) are the essential constituents or cofactors required to activate numerous enzymes and proteins, playing crucial role in various physiological processes. The disturbed levels of abovementioned elements may adversely affect the endocrine system, resulting in various thyroid disorders among other upsets. The aim of this study was to investigate possible associations between them and parameters of redox balance, thyroid function indices as well as clinical records (duration of disease and therapy, lag time between thyroid surgery and this study examination, LT4 dosage) in patients with different thyroid disorders, including malignant diseases of the gland. In the group of patients with papillary carcinoma, we found a statistically significant higher Cu concentration compared with controls and patients with Hashimoto disease. In the same groups, the parameter of Zn/Cu ratio demonstrated reciprocally arranged statistically significant differences. For the group of papillary cancer patients, there was a negative correlation between lag time since thyroid operation and GPX3 activity. Our data support hypothesis of indirect involvement of Zn and Cu in thyroid regulation. For selenium, lack of simple correlation between its serum level and thyroid indices implies the need for further research on other selenium status parameters more adequately depicting changes in endocrine system.

show abstract

Iodine and zinc, but not selenium and copper, deficiency exists in a male Turkish population with endemic goiter

Cited by 29 publications

References 16 publications

Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency

Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency

Prevalence of incidental thyroid cancer and its ultrasonographic features in subcentimeter thyroid nodules of patients with hyperthyroidism

Thyroid Disorders—Assessments of Trace Elements, Clinical, and Laboratory Parameters

Contact Info

Product

Resources

About