2016
DOI: 10.1016/j.tet.2016.03.018
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Iodine-catalyzed synthesis of fused tetracyclic pyridazino[6,1-b]pyrrolo[1,2-a]quinazolin-9(1H)-one derivatives via a tandem reaction

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Cited by 14 publications
(8 citation statements)
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“…The products 6 were obtained with good to excellent yields, as shown in Scheme 3. This protocol is characterized by high atom economy and formation of highly functionalized products in only one step [22] The product 6 is formed according to the proposed mechanism shown in Scheme 4. Initially, the carbonyl group is activated by iodine, acting as a Lewis acid.…”
Section: One-pot Reactionsmentioning
confidence: 99%
“…The products 6 were obtained with good to excellent yields, as shown in Scheme 3. This protocol is characterized by high atom economy and formation of highly functionalized products in only one step [22] The product 6 is formed according to the proposed mechanism shown in Scheme 4. Initially, the carbonyl group is activated by iodine, acting as a Lewis acid.…”
Section: One-pot Reactionsmentioning
confidence: 99%
“…One of its vari-ations includes the reaction of readily available anthranilic amides or hydrazides with pent-4-yn-1-ols or -carboxylic acids promoted by PdCl 4 [15], Au(І) [16][17][18] or Cu(ІІ) [19] salts. In another version, the target compounds were obtained by iodine-catalyzed reaction of the aforementioned anthranilic acid derivatives with 4-chloroketones or 4-oxocarboxylic acids in ionic liquids [20][21][22][23] or refluxing acetic acid [24,25]. An alternative approach involves cascade cyclization of anthranilamides with 4-chlorobutanoyl chloride [26,27].…”
Section: Introductionmentioning
confidence: 99%
“…According to our idea, the reaction of 2‐(1 H ‐benzo[ d ]imidazol‐2‐yl) aniline and levulinic acid was carried out catalyzed by TsOH, and gave benzo[4,5]imidazo[1,2‐ c ]pyrrolo[1,2‐ a ]quinazolin‐3(2 H )‐one as expected (Scheme , (3)). As our continuous research on the new methods for the preparation of polycyclic heterocycles , herein, we would like to report the TsOH‐catalyzed synthesis of fused pentacyclic heterocycles bearing quinazoline, benzimidazole, and pyrrole moieties at the same time.…”
Section: Introductionmentioning
confidence: 99%