Iodine—Champagne in a Tin Cup

Favero, Martin S.

doi:10.1017/s0195941700057076

Cited by 40 publications

(8 citation statements)

References 4 publications

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“…The available or titratable iodine level present in the contaminated bottle of PI was determined by sodium thiosulfate titration (15), and free iodine concentrations were performed colorimetrically from the amount of iodine (12) extracted into n-heptane, an immiscible organic solvent (14).…”

mentioning

confidence: 99%

“…Low, free iodine levels as measured in this contaminated lot of PI might affect the overall quality of an iodophor antiseptic. A typical 10% PI solution containing 1% available iodine (10,000 ppm) will continually release free iodine to provide an equilibrium value of approximately 1 ppm (1,12). The low 12 values found in the contaminated bottle of PI and the higher values associated with other Clinidine lots suggest that the product was not being formulated uniformly.…”

mentioning

confidence: 99%

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Prolonged survival of Pseudomonas cepacia in commercially manufactured povidone-iodine

Anderson

Vess

Panlilio

et al. 1990

Appl Environ Microbiol

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Pseudomonas cepacia organisms were recently recovered from a povidone-iodine antiseptic solution. During the subsequent investigation, laboratory studies were initiated to determine the survival time of these organisms in the iodophor solution, which contains 1% titratable iodine. The solution was sampled weekly upon receipt in our laboratory, and P. cepacia was subsequently recovered through 29 weeks of sampling. Current laboratory data and lot production date information from the manufacturer indicate that P. cepacia survived for up to 68 weeks from the time of manufacture. Scanning electron microscopic examination of contaminated solution demonstrated bacterial cells embedded in extracellular material.

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confidence: 99%

mentioning

confidence: 99%

Prolonged survival of Pseudomonas cepacia in commercially manufactured povidone-iodine

Anderson

Vess

Panlilio

et al. 1990

Appl Environ Microbiol

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“…Some clinicians also advocate a Betadine soak of the IUD prior to its insertion [48]. However, it is often unappreciated that Betadine and similar solutions are formulated as antiseptics and it is not the intent of manufacturers that they be used as disinfectants [49]. Indeed, microbial contamination of iodine sources is possible and may, in some cases, be the source of 'pseudobacteremia' in vivo [49].…”

Section: Discussionmentioning

confidence: 99%

“…However, it is often unappreciated that Betadine and similar solutions are formulated as antiseptics and it is not the intent of manufacturers that they be used as disinfectants [49]. Indeed, microbial contamination of iodine sources is possible and may, in some cases, be the source of 'pseudobacteremia' in vivo [49]. The same may be said for other antiseptics such as Benzalkonium chloride [50].…”

Section: Discussionmentioning

confidence: 99%

The Ljubljana IUDS: further observations on surface morphology

1986

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“…These compounds were designed originally to be used only as skin and mucosal germicidal antiseptics and not as chemical disinfectants. Although they are frequently used to disinfect instruments such as bronchoscopes, it is not the intent of the manufacturers of most of these compounds that they be employed as disinfectants for use on medical de-100 CONCISE CLINICAL STUDIES vices, hard surfaces, or environmental surfaces (16). Most iodophors are formulated to yield about 1% (10,000 ppm) "available" (or titratable) iodine.…”

Section: Discussionmentioning

confidence: 99%

Transmission of Tuberculosis by Flexible Fiberbronchoscopes

et al. 1983

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The development of flexible fiberoptic bronchoscopy was an important technologic advance in the diagnosis and management of patients with pulmonary disease. However, reliable decontamination and sterilization of these delicate instruments have been difficult. Many physicians routinely use a solution of povidone-iodine diluted in 70% ethyl alcohol and water to decontaminate fiberbronchoscopes, despite the fact that these iodophor compounds were developed as skin antiseptics and not as germicidal disinfectants for decontaminating instruments. We isolated a strain of Mycobacterium tuberculosis on a surveillance culture from a bronchoscope after it had been cleaned and disinfected with an iodophor solution. In another hospital, we documented the transmission of M. tuberculosis from one patient to another by a bronchoscope that had been disinfected with a commonly recommended iodophor solution. We then studied the tuberculocidal efficacy of various iodophor preparations used with exposure times from 10 to 30 min. In several experiments these iodophors failed to kill M. tuberculosis. Because iodophors do not reliably kill M. tuberculosis, they should not be used to disinfect fiberoptic bronchoscopes.

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Iodine—Champagne in a Tin Cup

Cited by 40 publications

References 4 publications

Prolonged survival of Pseudomonas cepacia in commercially manufactured povidone-iodine

Prolonged survival of Pseudomonas cepacia in commercially manufactured povidone-iodine

The Ljubljana IUDS: further observations on surface morphology

Transmission of Tuberculosis by Flexible Fiberbronchoscopes

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