This paper reveals the hidden dangers of reverse data modifications on distributed software with network synchronization, during the era of 5G, which may occur in more important domains, such as telemedicine and automatic driving. We used pseudo-codes to formally elaborate the distributed software architectures and design patterns. It is necessary to deal with three challenges for the modification of binary code and data in the distributed software architectures: (1) the base virtual addresses of software objects are changed frequently for safety; (2) prior knowledge of the reverse is not considered; (3) system memory values of some target objects are changed with extreme speed. For this purpose, a novel reverse modification method for binary code and data is proposed. According to the knowledge-based rules, our method can manipulate physical data, sight data, animation data, etc., while the game synchronization mechanism cannot detect the changes. The implementation details of our method are presented using high-level programming languages (C++) and low-level programming languages (assembly), based on multiple snippets, so that readers can understand both the overall distributed software developments and the corresponding reverse processes. In particular, two network games are used for the demonstrations in this paper. The demonstration results show that our proposed methodology is efficient (as proved by formulas and practices) to manipulate the codes and data of distributed software using a synchronization mechanism.