Iodine status of Turkish pregnant women and their offspring: A national cross-sectional survey

Vural, Mehmet; Koç, Esin; Evliyaoğlu, Olcay; Acar, Hazal Cansu; Aydın, Abdurrahman Fatih; Küçükgergin, Canan; Apaydın, Gözde; Erginöz, Ethem; Babazade, Xanim; Sharifova, Sabina; Perk, Yıldız; Satar, Mehmet; Büyükkurt, Selim; Şimşek, Hüseyin; Eroğlu, Canan; Yetkinel, Selçuk; Karagöl, Belma Saygılı; Karaşahin, Kazım Emre; Çelik, Hüseyin; Beksaç, Mehmet Sinan; Tanaçan, Atakan; Ecevit, Ayşe; Tugcu, Ali Ulas; Söylemez, Feride; Okulu, Emel; Önal, Esra; Oygür, Nihal; Kumru, Selahattin; Türkmen, Münevver; Turan, Özden; Cizmeci, Mehmet Nevzat; Varal, İpek Güney; Doğan, Peli̇n; Korkmazer, Engin; Arayıcı, Sema; Çıralı, Ceren; Özdemir, Öner; Ertuğrul, Sabahattin; Yolbaş, İlyas; Findik, Murat; Acunaş, Betül; Varol, GF; Taskin, Eren; Aydın, Murat; Çağlar, Ali Turhan; Tekgündüz, Kadir Şerafettin; Kara, Mustafa; Tekın, Nil; Velipaşaoğlu, Melih; Sarikabadayi, Yusuf Unal; Abbasoğlu, Aysel; Başar, Derya; El, Chen; Dolapçıoğlu, Kenan; Çetin, Hasan; Turhan, Azize; Desteli, Güldeniz; Uslu, Sinan; Bebek, Arzu Koç; Topçuoğlu, Sevilay; Okan, Meliha Aksoy; Eroğlu, Mustafa; Ercan, Tuğba Erener; Çelik, A.; Narter, Fatma; Sancak, Seda; Çetinkaya, Murat; Seçkin, Kerem Doğa; Gürsoy, Tuğba; Çelik, Emir; Çoban, Asuman; Aygün, E.; Bayraktar, Burak; Dane, P.B. Kilicoglu; Bozdağ, Şenol; Durankuş, Ferit; Özdemir, Hülya; Güçlü, Mehmet; Hamilçıkan, Şahin; Kovalak, Evrim Ebru; Gundogdu, Şule; Erden, E. Ciler; Yılmaz, Ahmet; Ataoğlu, Nazmi; Ataoğlu, Emel; Oğuz, Demet; Öncel, Mehmet Yekta; Arslan, Muhammad; Akar, Melek; Olukman, Özgür; Özer, İrfan; Çetin, Aslı; Öztürk, Ahmet; Ünal, Mustafa; Ozudogru, S.E.; Alíefendíoğlu, Didem; Güzoğlu, Nilüfer; Arısoy, Ayşe Engin; Şenel, Yasemin; Altunhan, Hüseyin; Yılmaz, Funda; Konak, Murat; Оздемир, Рамазан; Turgut, Hüseyin; Gökçe, İsmail Kürşat; Faydali, S.; Tanrıverdi, Sema; Özer, Erdal; Çelik, Yusuf; Durukan, Hüseyin; Caner, İbrahim; Genc, G.; Aygün, Canan; Tosun, Musa; Yesilirmak, C.; Erden, T.; Aslan, Yakup; Mutlu, Mehmet Fırat; Aran, Turhan; Kader, Shadia Abd el; Bor, Mustafa Vakur; Özkan, İlknur; Hilali, Neşe Gül; Toptan, Handan Hakyemez; Memur, Seyma; Sari, S.Sos Retno Dewi Puspita; Aydemir, Ceyda Aktolun; Ekmen, Sadrettin; Yurtcu, Engin; Şahin, Safiye Ağapinar; Kanburoğlu, Mehmet Kenan; Gürlek, Beril; Baran, Oğuz; Bozkurt, Özlem; Yücesoy, Ebru; Tunç, Tuğba

doi:10.1016/j.jtemb.2020.126664

Cited by 17 publications

(15 citation statements)

References 42 publications

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“…17 The current high CH rates in Turkey can be explained by a significant iodine deficiency in pregnant women. 22 The prevalence of CH reported in our study is slightly higher than the average for Turkey. This may be due to the fact that maternal data were obtained from Turkey's highest-capacity perinatology center, where pregnant women at risk of LBW and preterm birth comprise a high proportion of the patient population.…”

Section: Discussioncontrasting

confidence: 64%

“…In Turkey, iodization of all table salt has been mandated since 2000 18 . However, a national cross-sectional study in 2018 revealed that the prevalence of iodine deficiency in pregnant women was 78% in the Western Anatolia region where Ankara is located 22 . Therefore, this study reflect maternal SHT rates living in a region with iodine deficiency for pregnant women.…”

Section: Discussionmentioning

confidence: 99%

“…In Turkey, the prevalence of CH during our study period was high, at approximately 1/400 17 . The current high CH rates in Turkey can be explained by a significant iodine deficiency in pregnant women 22 . The prevalence of CH reported in our study is slightly higher than the average for Turkey.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Maternal Subclinical Hypothyroidism on Congenital Hypothyroidism Screening Results: A Retrospective Cohort Study

et al. 2022

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Objectives: This study aimed to evaluate the results of congenital hypothyroidism screening (CHS) in neonates born to women with subclinical hypothyroidism (SHT) during pregnancy and to identify maternal and neonatal characteristics associated with recall rate in CHS. Material and Methods: This retrospective cohort study included non-refugee pregnant women and newborn pairs who underwent thyroid function tests during prenatal follow-up between 2014 and 2017 and had neonatal CHS records. The women were evaluated overall and divided into euthyroidism (ET) and SHT groups according to their thyroid function tests. The groups were compared in terms of CHS results. Neonates with thyroid-stimulating hormone (TSH) levels < 5.5 mIU/L were considered “normal”, while those with values ≥ 5.5 mIU/l were “recall”. Results: The antenatal thyroid function data of a total of 22383 pregnant women were analyzed. Of these, 71.6% were ET and 16.3% were diagnosed as SHT. Overall, the recall rate accounted for 5.34 % of all CHS results and the recall rate was higher in the SHT group (7.10%) compared with the ET group (5.54%) (p=0.001). Being low birth weight (LBW) or large for gestation age (LGA), maternal TSH above the 97.5th percentile, and cesarean delivery increased the risk of recall in CHS (p˂0.05). Conclusion: The recall rate was higher among the neonates of mothers with SHT. Being LBW or LGA, maternal TSH above the 97.5th percentile, and cesarean delivery increased the risk of recall in CHS.

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Section: Discussioncontrasting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

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Effect of Maternal Subclinical Hypothyroidism on Congenital Hypothyroidism Screening Results: A Retrospective Cohort Study

et al. 2022

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“…Insufficient iodine intake is a continuing problem in pregnant women and their offspring in Turkey (40)(41)(42)(43). Thus, we hypothesized that with mutations in SLC26A4 and SLC5A5 involved in iodine transport in the thyroid gland, the case 3 might have presented as hypothyroidism at birth with the possible contribution of iodine deficiency, and recovered over time under LT4 therapy.…”

Section: Discussionmentioning

confidence: 99%

Genetic testing can change diagnosis and treatment in children with congenital hypothyroidism

Kara

Mammadova

Abur

et al. 2023

European Thyroid Journal

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Objective: Guidelines on congenital hypothyroidism (CH) recommend that genetic testing should aim to improve diagnosis, treatment or prognosis, but it is unclear which patients would benefit most from genetic investigation. We aimed to investigate the genetic etiology of transient (TCH) and permanent CH (PCH) in a well-characterized cohort, and thereby to evaluate the impact of genetic testing on the management and prognosis of children with CH. Methods: A total of 48 CH patients with normal, goitrous (n:5) or hypoplastic thyroid (n:5) were studied by high-throughput sequencing using a custom-designed 23-gene panel. Patients initially categorized as TCH (n:15), PCH (n:26) and persistent hyperthyrotropinemia (PHT, n:7) were re-evaluated after genetic testing. Results: Re-evaluation based on genetic testing changed the initial diagnoses from PCH to PHT (n:2) or TCH (n:3), and from PHT to TCH (n:5), which resulted in a final distribution of TCH (n:23), PCH (n:21) and PHT (n:4). Genetic analysis also allowed us to discontinue treatment in five patients with monoallelic TSHR or DUOX2, or no pathogenic variants. Main reasons for changes in diagnosis and treatment were the detection of monoallelic TSHR variants, and the misdiagnosis of thyroid hypoplasia on neonatal ultrasound in low birthweight infants. A total of 41 (35 different, 15 novel) variants were detected in 65% (n:31) of the cohort. These variants, which most frequently affected TG, TSHR and DUOX2, explained the genetic etiology in 46% (n:22) of the patients. Molecular diagnosis rate was significantly higher in patients with PCH (57%, n:12) than TCH (26%, n:6). Conclusions: Genetic testing can change diagnosis and treatment decisions in a small proportion of children with CH, but the resulting benefit may outweigh the burden of lifelong follow-up and treatment.

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“…This is in contrast to a study of South African women ( n = 562) that found UIC increase in each trimester (133 μg/L, 145 μg/L, and 156 μg/L) [ 74 ]. Another study completed in Turkey measured newborn UIC and found 51% of newborns were I deficient [ 75 ]. Finally, studies of Swedish women ( n = 604) [ 76 ], Cyprian women ( n = 128) [ 77 ], and Latvian women ( n = 129) [ 78 ] report UICs of 113 μg/L, 105 μg/L, and 147 μg/L, respectively, suggesting mild-to-moderate I insufficiency may occur in these countries.…”

Section: Iodine and Thyroid Function In Pregnancymentioning

confidence: 99%

A Scoping Review of Iodine and Fluoride in Pregnancy in Relation to Maternal Thyroid Function and Offspring Neurodevelopment

Griebel-Thompson¹,

Sands²,

Chollet‐Hinton³

et al. 2023

Advances in Nutrition

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Iodine status of Turkish pregnant women and their offspring: A national cross-sectional survey

Cited by 17 publications

References 42 publications

Effect of Maternal Subclinical Hypothyroidism on Congenital Hypothyroidism Screening Results: A Retrospective Cohort Study

Effect of Maternal Subclinical Hypothyroidism on Congenital Hypothyroidism Screening Results: A Retrospective Cohort Study

Genetic testing can change diagnosis and treatment in children with congenital hypothyroidism

A Scoping Review of Iodine and Fluoride in Pregnancy in Relation to Maternal Thyroid Function and Offspring Neurodevelopment

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