Iodine stimulates estrogen receptor singling and its systemic level is increased in surgical patients due to topical absorption

He, Shasha; Wang, Bingchan; Lu, Xiyi; Miao, Shuying; Yang, Fengming; Zava, Theodore; Ding, Qiang; Zhang, Shijiang; Liu, Jiayin; Zava, David T.; Shi, Yuye

doi:10.18632/oncotarget.20633

Cited by 12 publications

(9 citation statements)

References 44 publications

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“…1 ). Conversely, excess iodide intake also plays an unfavorable role in BC by stimulating ER-α transcriptional activity [ 14 ]. Malya FU et al reported a high urine-iodine concentration (UIC) in a significantly larger portion of BC patients than controls [ 15 ].…”

Section: Iodidementioning

confidence: 99%

Review of the possible association between thyroid and breast carcinoma

et al. 2018

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BackgroundThyroid and breast cancer are two of the malignant diseases with highest incidence in females. Based on clinical experience, breast and thyroid cancer often occur metachronously or synchronously. Therefore, thyroid and breast cancer might share some common etiological factors. The relationship between these diseases has attracted substantial attention, and because these two glands are both regulated by the hypothalamic-pituitary axis, such a relationship is not surprising. A study of this relationship will be useful for obtaining a better understanding of the mechanism by which these two malignancies co-occur.Main bodyThis study reviewed the progress in research on the roles of iodine intake, folate metabolism, obesity, gonadal hormones, and thyroid hormone in thyroid and breast cancer. These studies evaluating the etiological roles of these factors in linking breast and thyroid cancer might also improve our understanding and identify new therapeutic approaches, such as sodium/iodide symporter-mediated radioiodine therapy and thyroid-stimulating hormone receptor antagonists, for breast cancer. In addition, some specific treatments for each cancer, such as radiotherapy for breast cancer or radioactive iodine therapy for thyroid cancer, might be risk factors for secondary malignances, including breast and thyroid cancer.ConclusionsStudies of the precise relationship between the co-occurrence of breast and thyroid cancer will certainly improve our understanding of the biological behaviors of these two malignancies and direct evidence-based clinical practice.

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Section: Iodidementioning

confidence: 99%

Review of the possible association between thyroid and breast carcinoma

et al. 2018

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“…Autoimmune thyroid diseases are characterized by increased levels of TPOAb and TgAb, and an association between HT and BC has been reported previously [ 17 , 26 , 32 , 33 ]. In particular, the prevalence of these antibodies in BC patients is significantly higher than in healthy controls [ 34 ].…”

Section: Discussionmentioning

confidence: 82%

“…This alteration in endocrine state may increase the risk of BC, especially in young woman [ 25 ]. In contrast, excess iodine intake also plays an unfavorable role by stimulating ER-α transcriptional activity in BC cells, thus favoring its growth [ 26 ]. Radioiodine treatment for differentiated TC increases the risk of secondary BC in female patients [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Development of Histologically Verified Thyroid Diseases in Women Operated for Breast Cancer: A Review of the Literature and a Case Series

Famà

Sindoni

Sun

et al. 2022

JCM

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Background: The possible relationships between breast and thyroid diseases have been reported in the literature. The purpose of our study was to evaluate the occurrence of histologically verified thyroid pathologies in women who were diagnosed with breast cancer and, after mastectomy/quadrantectomy complemented by oncological treatment, were thyroidectomized based on their periodic thyroid evaluation. Patients and Methods: Our series consist of 31 women with a mean age of 62.9 ± 10.9 years (range, 45–81) treated for breast cancer (18 right-sided, 11 left-sided, and 2 bilateral), of whom 29 were thyroidectomized, since two women who developed Graves’ disease refused thyroidectomy. These 31 women belong to a cohort of 889 women who referred to the Breast Surgery Unit of our university hospital during the period January 2010 through December 2020. Results: The mean time interval between breast cancer and thyroid pathologies was 48.1 ± 23.4 months (range, 12–95). The final diagnosis at histopathology was infiltrating ductal breast carcinoma in 26 women (with 2/26 patients having bilateral carcinoma) and infiltrating lobular breast carcinoma in the other 5 women. Ten of the twenty-nine thyroidectomized women (34.5%) had a thyroid malignancy on histology: five papillary carcinomas, three papillary micro-carcinomas and two follicular carcinomas. Two of the five women with papillary carcinoma also had histological evidence of chronic lymphocytic thyroiditis/Hashimoto’s thyroiditis, which was also detected in another five women with benign thyroid diseases. Conclusions: We suggest that breast cancer survivors should be made aware of the possible increased risk of thyroid pathologies (including thyroid malignancy) so that they can undergo screening and follow-up.

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“…One study found iodine stimulated the transcriptional activity of estrogen receptor and increased the expression of several ER regulated genes in breast cancer cells. However, there are currently no straightforward evidence to support whether iodine could affect the ER-related pathways in thyroid cancer (36). A similar dropping F/M ratio was seen in Geneva, Switzerland where there was a significant increase of PTC from 1970-1974 to 1995-1998, with a decrease of female/ male ratio from 4.4 to 2.4, while the iodine intake did not change (29,33).…”

Section: Discussionmentioning

confidence: 87%

Changing patterns of thyroid cancer in different stages of Universal Salt Iodization in Peking Union Medical College Hospital, 1986–2018

Zeng¹,

Li²,

Kang³

et al. 2020

Gland Surg

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Backgrounds: Iodine intake may be associated with increased thyroid cancer, but its effect varied from places to places. Universal salt iodization (USI) has been introduced in China from 1996 to 2012. The effects of increased iodine intake on thyroid cancer needs to be investigated in China.Methods: From 1986 to 2018, patients who had thyroidectomies in Peking Union Medical College Hospital (PUMCH) were retrospectively studied. The detection rate, constituent ratio, mean age, sex distribution of thyroid cancer and the pattern of papillary thyroid microcarcinoma (PTMC) were compared between different historical periods. Results:The detection rate of thyroid cancer in thyroid surgery significantly increased from 6.77% to 75.78% post-USI, with papillary thyroid cancer (PTC) being the majority, and that of follicular thyroid cancer (FTC) and medullary thyroid cancer (MTC) showed only minor changes. There was a descending trend of female/male ratio in PTC from 3.7 to 2.8, and a slight decrease of mean age observed in PTC after USI compared with during USI. The percentage of PTMC in PTC decreased from 13.99% to 8.64%, with a lower mean age after USI (44.88±10.37 vs. 46.44±10.42). Prevalence of goiter coexisting with PTMC was also lower after USI than during USI (31% vs. 41%).Conclusions: With the popularization of iodized salt, PTC has become the major type in surgery for thyroid cancer, and trends in other histological subtypes remained mostly stable over the periods. The increase in PTC cannot be attributed to the increase of PTMC which is smaller than 1 cm, indicating that contributing factors other than diagnostic activities, may play a role in the increase of PTC.

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Iodine stimulates estrogen receptor singling and its systemic level is increased in surgical patients due to topical absorption

Cited by 12 publications

References 44 publications

Review of the possible association between thyroid and breast carcinoma

Review of the possible association between thyroid and breast carcinoma

Development of Histologically Verified Thyroid Diseases in Women Operated for Breast Cancer: A Review of the Literature and a Case Series

Changing patterns of thyroid cancer in different stages of Universal Salt Iodization in Peking Union Medical College Hospital, 1986–2018

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