Iohexol Plasma Clearance in Healthy Dogs and Cats

Goy‐Thollot, Isabelle; Chafotte, Caroline; Besse, Stéphane; Garnier, François; Barthez, Paul Y.

doi:10.1111/j.1740-8261.2006.00133.x

Cited by 37 publications

(49 citation statements)

References 36 publications

(66 reference statements)

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“…The results of Pcio in healthy cats were similar to reference values published by other authors (9,15,27).They differ only slightly from those reported by Miyamoto (19,20), which can probably be connected with the other procedure of examination -animals underwent sedation in the course of the experiment. As it has been proven in the present research, Pcio in cats suffering from renal disease is significantly statistically lower than in healthy cats.…”

Section: Discussionsupporting

confidence: 75%

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Usefulness of Serum Cystatin C Measurement for Assessing Renal Function in Cats

Poświatowska-Kaszczyszyn

2012

Bulletin of the Veterinary Institute in Pulawy

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The aim of the work was to determine the concentration of serum cystatin C and usability of its measurement in diagnostics of renal failure in cats. The reference point was the value of glomerular filtration rate (GFR), calculated on the basis of plasma clearance of iohexol (Pcio). Seventy cats were divided into two groups: group I -24 healthy cats, group II -46 cats affected with renal dysfunction. The measurement of serum cystatin C was done according to immunonefelometric method. In order to estimate Pcio, the following blood samples were collected: pre-sample -0, and samples collected 120, 180, 240, and 300 min after intravenous administration of iohexol. Its concentration was determined using high performance liquid chromatography. Pcio was obtained using a one-compartment model, according to the method developed by Krutzen Back and Nilsson-Ehl. Serum concentration of cystatin C in cats with renal dysfunction was significantly statistically higher (1.3 ± 0.6 mg/L) as compared to the group of healthy animals (0.7 ± 0.2 mg/L). Statistical analysis of the data confirmed strong correlation between GFR and serum concentration of cystatin C (r = -0.51). Data analysis on the basis of the receiver operating characteristic curve proved that cystatin C seems to be more reliable parameter than creatinine in the assessment of kidneys function in cats and the measurement of cystatin C in blood serum can be of a considerable meaning as far as early diagnosis of renal failure in cats is concerned.

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Section: Discussionsupporting

confidence: 75%

“…The dosage of iohexol given intravenously is different: 450 mg/kg b.w. (9) or 90 mg/kg b.w. in healthy cats and 45 mg/kg b.w.…”

mentioning

confidence: 99%

Usefulness of Serum Cystatin C Measurement for Assessing Renal Function in Cats

Poświatowska-Kaszczyszyn

2012

Bulletin of the Veterinary Institute in Pulawy

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“…This assumes that renal clearance is associated with body weight in a linear fashion; however, this may not be the case in very small (<10 kg) or very large (>50 kg) dogs due to metabolic scaling (Goy-Thollot et al, 2006b; Bexfield et al, 2008). In people, body surface area is used for standardization rather than body weight.…”

Section: Determination Of Glomerular Filtration Ratementioning

confidence: 99%

“…In people, body surface area is used for standardization rather than body weight. Some veterinary studies have applied this method (Moe and Heiene, 1995; Goy-Thollot et al, 2006a; Goy-Thollot et al, 2006b); however, the most appropriate formula for estimating body surface area in veterinary species is unknown. Extracellular fluid volume (ECFV) has also been used as a method of standardization, (Bexfield et al, 2008; Heiene et al, 2009) because ECFV regulation is closely related to GFR; however, results have been variable and this method needs to be evaluated more before its use can be recommended.…”

Section: Determination Of Glomerular Filtration Ratementioning

confidence: 99%

An overview of glomerular filtration rate testing in dogs and cats

Hendy-Willson

Pressler

2011

The Veterinary Journal

100

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Determination of glomerular filtration rate (GFR) is a valuable, yet underused, diagnostic tool for evaluating renal function in dogs and cats. This article first reviews the hormonal and hemodynamic factors which contribute to GFR, followed by a description of considerations when selecting a pharmacokinetic model and methods of animal-to-animal standardization. The bestcharacterized existing GFR markers, including creatinine, radiolabeled markers, and iohexol, are reviewed in depth, as well as alternative but lesser-used techniques. A weighted means analysis of reported GFR measurements in healthy dogs and cats and a review of selected studies that have examined GFR alterations in animals with naturally-occurring and experimental diseases provide the reader with preliminary guidelines on expected GFR results in these species and disease conditions.

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“…Normalization to BSA was used because it has been shown to be the optimal method of normalization in dogs. 15 Iohexol is an iodinated, water-soluble, nonionic, lowosmolar contrast medium that has been shown to be a good alternative to inulin and radioactive tracers for estimation of GFR in human, 22,23 pig, 24 horse, 8 dog, [25][26][27] and cat. 28,29 Advantages of iohexol over other tracers include lack of radiation hazard and associated radiation protection measures, its availability, the ease of measuring plasma concentration, and the possibility of remote and delayed assay.…”

Section: Discussionmentioning

confidence: 99%

Simplified Methods for Estimation of Plasma Clearance of Iohexol in Dogs and Cats

Goy‐Thollot¹,

Besse²,

Garnier³

et al. 2006

Veterinary Internal Medicne

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The purpose of this study was to evaluate simplified methods for iohexol plasma clearance estimation in dogs and cats. Serial blood samples were taken before and 5, 20, 40, 60, 80, 100, 120, 150, 180, and 240 minutes after a bolus injection of iohexol in 51 dogs and 25 cats. Iohexol plasma concentration was determined with X-ray fluorescence. Clearance was calculated by dividing the injected dose by the area under the plasma tracer elimination curve estimated with a 2-compartment pharmacologic model. Clearance was normalized to body surface area (BSA). The 10-point clearance was used as a reference for the evaluation of simplified methods. A 2-sample method based on a single exponential fit and a single-sample method based on a linear quadratic model were investigated. Simplified methods were evaluated by calculating the standard deviation of the difference (SDD) between the clearances obtained with the simplified methods and the 10-point reference method. All combinations of sampling times were evaluated. The best sampling times were chosen for dogs and cats as the ones yielding the lowest SDD. Linear regression analysis was performed between the reference method and the optimized simplified methods. The best combination of time for the 2-sample method was 5 and 120 minutes in dogs and 20 and 180 minutes in cats. The best time for sampling in the single-sample method was 120 minutes in dogs and 80 minutes in cats. Plasma clearance of iohexol can be estimated in dogs and cats from 1 or 2 blood samples with a reasonable margin of error.

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Iohexol Plasma Clearance in Healthy Dogs and Cats

Cited by 37 publications

References 36 publications

Usefulness of Serum Cystatin C Measurement for Assessing Renal Function in Cats

Usefulness of Serum Cystatin C Measurement for Assessing Renal Function in Cats

An overview of glomerular filtration rate testing in dogs and cats

Simplified Methods for Estimation of Plasma Clearance of Iohexol in Dogs and Cats

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