“…Apparently, increases in blood hydrogen ion concentration decrease the binding of calcium to plasma proteins, thus augmenting the free, unbound calcium moiety. Finally, increases in the serum concentration of anions such as phosphate, citrate, sulfate, or bicarbonate reduce the ionized calcium concentration because of increased complexation of calcium (159,223,225,227). Overall Ca2+ homeostasis is maintained by the complex interrelationship between intestinal absorption, bone resorption and formation, and urinary excretion.…”