Ion chromatography on a latex-coated silica monolith column

Glenn, Karen M.; Lucy, Charles A.; Haddad, Paul R.

doi:10.1016/j.chroma.2007.01.098

Cited by 52 publications

(35 citation statements)

References 28 publications

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“…Polycationic latexes (80-140 nm) electrostatically adsorb onto the surface to form a pellicular ion exchange layer. Agglomerated phases, such as those used by Dionex Corporation (Sunnyvale, CA, USA), are easy to prepare [4,26] and provide high efficiency for ion exchange separations [27]. The electrostatic attachment is extremely rugged, able to withstand pH 0 to 14 and 1 to 100% v/v of common RP solvents in aqueous mixtures [25].…”

Section: Introductionmentioning

confidence: 99%

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Agglomerated silica monolithic column for hydrophilic interaction LC

Ibrahim

Zhou

Lucy

2010

J of Separation Science

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Hydrophilic interaction LC (HILIC) has gained wide acceptance in recent years due to its ability to retain and separate polar compounds such as pharmaceuticals. Most commercial HILIC phases are particle based, which limit the speed with which HILIC separations can be performed. Herein, agglomerated silica monolithic columns are prepared by electrostatically attaching polyionic latex particles onto a silica monolith by simply flushing a suspension of the ionic latex through a silica monolith. Such phases retain the high efficiency and permeability of the native silica monolith, while the agglomerated phase is easy to introduce and provides excellent mass transfer. High %ACN in the mobile phase dramatically increases the efficiency and retention, consistent with HILIC behavior. Test analytes such as benzoates, nucleotides and amino acids are separated with plate heights of 25-110 microm. The high permeability of monoliths allows HILIC separations to be performed with baseline resolution in less than 15 s. Electrostatic repulsion-hydrophilic liquid interaction chromatographic retention behavior of the latex-coated monoliths is verified using amino acids as test analytes.

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Section: Introductionmentioning

confidence: 99%

“…Monolithic stationary phases (www.merck.de/servlet/PB/ MENU/1209750) can provide comparable efficiency but with much lower backpressure [2][3][4][5][6]. Monolithic columns have a different geometry compared with particle-based columns.…”

Section: Introductionmentioning

confidence: 99%

Agglomerated silica monolithic column for hydrophilic interaction LC

Ibrahim

Zhou

Lucy

2010

J of Separation Science

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“…Therefore, the development of monolithic IC columns has been focused on the use of capillary columns/systems, in which fixing the monolith inside the column is less troublesome and less possibility for shrinkage of the monolith to occur. It was also reported that dynamically modification of bare silica monolithic columns with latex nanoparticles achieved 50% higher efficiency than the similar type monolithic ODS column coated with cationic surfactant didodecyldimethyl ammonium bromide (DDAB) [70].…”

Section: Monolithic Stationary Phases For Capillary Icmentioning

confidence: 99%

Development of Micro-Flow-Controlled Techniques and Novel Stationary Phases in Capillary Liquid Chromatography

Lim

2015

Chromatography

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This focusing review summarizes our recent works on the dissemination of capillary liquid chromatography through various approaches, i.e. simple stepwise-gradient elution system, on-line sample enrichment system, alternate-pumping recycle chromatography system, on-line immobilized-enzyme reactor, development of novel stationary phases, etc. Capillary liquid chromatography saves energy and waste, and it possesses several advantages over the conventional liquid chromatography; however, it has not been much popularized since its appearance and most users still prefer to use conventional liquid chromatography if there is a choice between them. Our research focuses on, but not limited to, developing versatile capillary liquid chromatography systems that are not only environmental-friendly but also user-friendly, and novel stationary phases that could be operated under mixed modes conditions by manipulating the eluent, which are applicable to real samples analyses and will therefore eventually switch the users from "conventional" to "capillary".

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“…[40][41][42][43] In this work, possibilities for fast ion chromatographic separations are further explored and expanded upon. Our approach is to use the Chromolith Speed ROD RP-18e column, a reversed-phase monolithic silica phase, to perform fast and simultaneous determination of BF4 -, SCN -and PF6 -by HPLC with direct conductivity detection.…”

Section: -39mentioning

confidence: 99%