Ion Mobility Spectrometry: Arriving on Site and Moving beyond a Low Profile

Baumbach, J. I.; Eiceman, Gary A.

doi:10.1366/0003702991947847

Cited by 188 publications

(144 citation statements)

References 71 publications

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“…Further details are described in the literature. 1 If a complex mixture of analytes, such as the headspace of beer wort is investigated, ions of several compounds may occur at the same drift time. Therefore, additional pre-separation by a gas-chromatographic (GC) column in front of the IMS inlet provides retention time as an additional characteristic of the different analytes.…”

Section: Methodsmentioning

confidence: 99%

“…It combines a number of characteristics that make it suitable as a method for the detection of volatile compounds in the gas phase for process control. 1,6,16 Commercial ion mobility spectrometers (IMS) are already available in the range of 10-20,000 US dollars depending on the application. After set-up, operation is possible by technical personnel.…”

Section: Introductionmentioning

confidence: 99%

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Beer Fermentation Control Using Ion Mobility Spectrometry - Results of a Pilot Study

Vautz

Baumbach

Jung³

2006

Journal of the Institute of Brewing

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Beer fermentation -a time consuming part of the production process -is typically terminated based on the degradation of diacetyl and 2,3-pentanedione below the odour threshold. Presently no on-line control of both analytes is available. As a consequence, fermentation is often carried out longer than necessary, thus decreasing productivity. In this pilot study, an ion mobility spectrometer using a UV-lamp as an ionisation source and a GC column (30°C constant) for pre-separation were used for the rapid determination of both analytes from the headspace of beer wort, during and after fermentation. Samples were heated to 60°C. Results from such analyses were available after a few minutes without further sample treatment or pre-concentration. Detection limits were below the odour threshold (ng/L range in the gas phase corresponding to the µg/L range in the liquid phase). Results were validated by comparison with the brewery's standard GC-MS method. When applied on-line and in-situ, as a routine test in a brewery, it will help to ensure low levels of diacetyl and 2,3-pentanedione in the product on the one hand and will increase productivity by saving time during fermentation on the other (up to one day in large breweries and even more than one day in smaller ones) by obtaining on-line data of the relevant analytes. After optimisation of the method, further odour or taste relevant analytes could be determined simultaneously.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Beer Fermentation Control Using Ion Mobility Spectrometry - Results of a Pilot Study

Vautz

Baumbach

Jung³

2006

Journal of the Institute of Brewing

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“…Ion mobility (IM) spectrometry is a robust method that allows for the rapid separation and analysis of a wide range of compounds [14]. In this technique, ions can be generated by several methods such as pyrolysis, electrospray, and laser desorption prior to entering a gas-filled mobility drift cell region.…”

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confidence: 99%

“…In this technique, ions can be generated by several methods such as pyrolysis, electrospray, and laser desorption prior to entering a gas-filled mobility drift cell region. In the drift cell, ions obtain an average drift velocity from an electric field based upon their collision cross section (⍀) or shape, which allows for the separation of different shaped molecules [14,15]. The coupling of IM to mass spectrometry (IM-MS) has been used for the analysis of a large variety of samples including explosives, drug molecules, biomolecules, etc.…”

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confidence: 99%

Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS

Jackson

Wang

Woods

et al. 2005

J. Am. Soc. Mass Spectrom.

152

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After water, lipids are the most common biomolecules found in the brain (12%). A brief perusal of the physiology, anatomy, and pathophysiology of the brain illustrates the importance of lipids. Recent advances in mass spectrometry have allowed the direct probing of tissues. However, most studies have focused on proteins. In the present work, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) and MALDI-ion mobility (IM)-TOFMS were employed for direct analysis of phospholipids in rat brain tissue. Molecular ions (MH ϩ ) corresponding to phosphatidylcholines, phosphatidylethanolamines, and sphingomyelin, were recorded. When studying pharmacology, we learn that many therapeutic compounds are stored in the body's adipose tissue. MALDI-TOFMS and MALDI-IM-TOFMS were thus used to analyze rat brain tissue with chlorisondamine added directly onto the tissue slice. With both techniques, noncovalent complexes between the tissue phospholipids and chlorisondamine were detected. In addition, MALDI-IM-TOFMS of noncovalent complexes between phospholipids and chlorisondamine displayed a mobility between that of an isobaric lipid and peptide. (J Am Soc Mass Spectrom 2005, 16, 133-138)

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“…The working principle of IMS is described in detail in [2]. Thus, we just give a brief summary here.…”

Section: Ims Technologymentioning

confidence: 99%

IMS2 – An integrated medical software system for early lung cancer detection using ion mobility spectrometry data of human breath

Baumbach

Bunkowski

Lange

et al. 2007

Journal of Integrative Bioinformatics

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IMS 2 is an Integrated Medical Software system for the analysis of Ion Mobility Spectrometry (IMS) data. It assists medical staff with the following IMS data processing steps: acquisition, visualization, classification, and annotation. IMS 2 provides data analysis and interpretation features on the one hand, and also helps to improve the classification by increasing the number of the pre-classified datasets on the other hand. It is designed to facilitate early detection of lung cancer, one of the most common cancer types with one million deaths each year around the world. After reviewing the IMS technology, we first describe the software architecture of IMS 2 and then the integrated classification module, including necessary pre-processing steps and different classification methods. The Lung Hospital Hemer (Germany) provided IMS data of 35 patients suffering from lung cancer and 72 samples of healthy persons. IMS 2 correctly classifies 99% of the samples, evaluated using 10-fold cross-validation.

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Ion Mobility Spectrometry: Arriving on Site and Moving beyond a Low Profile

Cited by 188 publications

References 71 publications

Beer Fermentation Control Using Ion Mobility Spectrometry - Results of a Pilot Study

Beer Fermentation Control Using Ion Mobility Spectrometry - Results of a Pilot Study

Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS

IMS2 – An integrated medical software system for early lung cancer detection using ion mobility spectrometry data of human breath

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