Ion-neutral gas reactions in a collision/reaction cell in inductively coupled plasma mass spectrometry: Correlation of ion signal decrease to kinetic rate constants

Gray, Patrick J.; Olesik, John W.

doi:10.1016/j.sab.2014.10.003

Cited by 11 publications

(3 citation statements)

References 51 publications

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“…The CO 2 gas pressure at the two flow rates used in this study, the collisional cross sections (σ) for each element, and the kinetic energy of the ions in our study were estimated using models developed for the Agilent ICP-MS/MS described previously and that were calibrated to previous guided ion beam mass spectrometry measurements (Gray and Olesik 2015, Yamada 2015, Harouaka et al 2021. Note that a similar calibration would be needed to apply these models to ICP-MS/MS systems from other manufacturers.…”

Section: Characterisation Of Crc Reaction Conditions and Ion Kinetic ...mentioning

confidence: 99%

Gas‐Phase Ion‐Molecule Interactions in a Collision Reaction Cell with ICP‐MS/MS: Investigations with CO₂ as the Reaction Gas

Harouaka

Melby

Bylaska

et al. 2022

Geostandard Geoanalytic Res

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Carbon dioxide (CO2) was used as a reaction gas to investigate the gas‐phase ion‐molecule interactions using the Agilent 8900 ICP‐MS/MS. A solution containing forty‐five elements representative of the periodic table was used to supply the ions to react with CO2 in the collision/reaction cell (CRC). The only significant product ions formed were monoxides. The general reactivity was shown to be consistent with density functional theory (DFT)‐predicted reaction enthalpies, such that all predicted exothermic reactions produced product ions at levels of at least 1% of the unreacted ion. Most endothermic reactions observed had sufficient kinetic energy in excess of the reaction enthalpies. Our results suggest that reaction enthalpy is a reasonable predictor of reactivity with CO2 on the timescales of the interactions in non‐thermal ICP‐MS/MS systems. The ease and rapidity of data collection with the ICP‐MS/MS and DFT calculations using the NWChem suite has value given the scarcity of thermochemical data of CO2 reactions in the literature. These studies are especially useful for the identification of targeted reaction chemistries to be leveraged for analytical method development, such as for the inline separation of isobaric interferences from analytes of interest.

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Section: Characterisation Of Crc Reaction Conditions and Ion Kinetic ...mentioning

confidence: 99%

Gas‐Phase Ion‐Molecule Interactions in a Collision Reaction Cell with ICP‐MS/MS: Investigations with CO₂ as the Reaction Gas

Harouaka

Melby

Bylaska

et al. 2022

Geostandard Geoanalytic Res

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“…Compared with the aqueous sample solution, organic samples require plasma conditions with higher analysis temperatures, and the generated high background signals increase the interferences . A collision/reaction cell (CRC) is an effective tool for ICP-MS in resolving spectral interference which can be eliminated through bias voltage with kinetic energy discrimination (collision mode) or the reaction chemistry (reaction mode). − The collision mode is almost universally adopted by traditional ICP-QMS, effectively eliminating the spectral interference of the polyatomic ions in various complex matrix samples. − However, it cannot effectively remove the isobaric and doubly charged spectral interference. For trace elements analysis, the reaction mode has higher sensitivity than the collision mode, − but the highly reactive gases react with matrix components, analytes, and polyatomic ions in the CRC producing new interferences.…”

Section: Introductionmentioning

confidence: 99%

N₂O as a Universal Reaction Gas to Overcome Spectral Interference in Determining Metal Impurities in Mg(TFSI)₂ Electrolytes for Rechargeable Magnesium Batteries by Inductively Coupled Plasma Tandem Mass Spectrometry

Huang

et al. 2022

Anal. Chem.

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A new strategy for the determination of metal impurities in magnesium bis(trifluoromethanesulfonyl)imide (Mg(TFSI)2) electrolytes for rechargeable magnesium batteries using inductively coupled plasma tandem mass spectrometry (ICP-MS/MS) was proposed. Mg(TFSI)2 was dissolved in 1,2-dimethoxyethane (DME), and 13 metal impurity elements were directly determined. Since N2 has a lower O atom affinity (1.6 eV) than the O atom (5.2 eV), N2O was a more effective O atom transfer gas than O2. In the MS/MS mode, N2O was selected as the reaction gas, and high sensitivities and low limits of detection (LODs) of analytes were obtained by mass shift methods. The accuracy of proposed analytical methods was assessed by the spike recovery experiments and comparative analyses using sector field inductively coupled plasma mass spectrometry (SF-ICP-MS). LODs were in the range of 0.18–26.6 ng kg–1, the recoveries were 92.5%–107%, and the relative standard deviation (RSD) was 2.0%–5.3%. No significant difference was observed between the ICP-MS/MS and SF-ICP-MS results at a 95% confidence level. The measurement realized the rapid determination of 13 metal impurity elements in Mg(TFSI)2 using N2O as a reaction gas with high sensitivity, accuracy, and precision. The method was applied for the analysis of Mg(TFSI)2 products with satisfactory results.

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“…Reaction cell technique offers an effective approach for the separation of spectral interferences in the measurement by ICP-MS. 15 In order to achieve specific separations of various spectral interferences, some kinds of gases had been explored as the reaction gas in the reaction cell of ICP-MS, including H 2 , O 2 , NH 3 , CH 3 F, N 2 H 6 , N 2 O, CO, NO, and SF 6 . 5 A systematic investigation of the ion-molecule reactions in the reaction cell will provide useful information for the development of a method for separating spectral interferences. However, it was difficult to elucidate the ion-molecule reactions by using a traditional ICP-MS instrument with a single quadrupole mass spectrometer (QMS) since the ionic species entering the reaction cell were extremely complicated, including polyatomic ions from the matrix of the sample, the solvent, the argon plasma gas, and the constituents of air.…”

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Classification of Chemical Elements in the Reaction Cell of ICP-MS Based on the Affinities with Sulfur, Oxygen, and Fluorine

Zhu

2018

Chem. Lett.

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Classification of chemical elements in the reaction cell of an inductively coupled plasma mass spectrometer (ICP-MS) was first reported based on the affinities with multiple elements, i.e. sulfur, oxygen, and fluorine. The data were summarized in the periodic table based on the affinity with each of the three elements mentioned above. An example of the application of the present results was illustrated by analyzing Y and La in the matrix of Sr and Ba, offering apparently improved background equivalent concentration (BEC) and detection limits (DL). Keywords: Classification | Chemical element | Reaction cellSeparation of spectral interferences is one of the key issues for elemental measurement by using an inductively coupled plasma mass spectrometer (ICP-MS), which is a well-developed instrument capable of simultaneous measurement of multiple elements in a wide linearity range up to nine orders of magnitude. Reaction cell technique offers an effective approach for the separation of spectral interferences in the measurement by ICP-MS. 15 In order to achieve specific separations of various spectral interferences, some kinds of gases had been explored as the reaction gas in the reaction cell of ICP-MS, including H 2 , O 2 , NH 3 , CH 3 F, N 2 H 6 , N 2 O, CO, NO, and SF 6 .5 A systematic investigation of the ion-molecule reactions in the reaction cell will provide useful information for the development of a method for separating spectral interferences. However, it was difficult to elucidate the ion-molecule reactions by using a traditional ICP-MS instrument with a single quadrupole mass spectrometer (QMS) since the ionic species entering the reaction cell were extremely complicated, including polyatomic ions from the matrix of the sample, the solvent, the argon plasma gas, and the constituents of air.Detailed work on multiple elements in the periodic table had been carried out regarding the reactions with oxygen and fluoromethane, respectively, based on laboratory-developed selected ion flow tube (SIFT) ICP-MS. 68 In these studies, both atom attachment and molecule attachment have been observed with oxygen and fluoromethane, respectively, as the reaction cell gas. High-order reactions with attachment of multiple molecules had also been observed for some elements. Such kinds of information benefit the built up of spectral separation strategies in ICP-MS measurement. It is notable that SIFT-ICP-MS was developed in the Bohme group and was not commercially available for common ICP-MS users.In recent years, the commercial availability of ICP-QMS/ QMS, i.e. ICP-MS with a pair of QMS and an octapole reaction cell (ORC), makes it possible to investigate in detail ionmolecule reactions in the reaction cell by common ICP-MS users. The first QMS (QMS1) of the ICP-QMS/QMS instrument permits the ions with selected mass-to-charge (m/z) ratio to enter the ORC and to react with the reaction gas molecules so as to exclude the interferences from ionic species with unwanted m/z ratios, which were problematic when a traditional ICP-MS...

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Ion-neutral gas reactions in a collision/reaction cell in inductively coupled plasma mass spectrometry: Correlation of ion signal decrease to kinetic rate constants

Cited by 11 publications

References 51 publications

Gas‐Phase Ion‐Molecule Interactions in a Collision Reaction Cell with ICP‐MS/MS: Investigations with CO₂ as the Reaction Gas

Gas‐Phase Ion‐Molecule Interactions in a Collision Reaction Cell with ICP‐MS/MS: Investigations with CO₂ as the Reaction Gas

N₂O as a Universal Reaction Gas to Overcome Spectral Interference in Determining Metal Impurities in Mg(TFSI)₂ Electrolytes for Rechargeable Magnesium Batteries by Inductively Coupled Plasma Tandem Mass Spectrometry

Classification of Chemical Elements in the Reaction Cell of ICP-MS Based on the Affinities with Sulfur, Oxygen, and Fluorine

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Ion-neutral gas reactions in a collision/reaction cell in inductively coupled plasma mass spectrometry: Correlation of ion signal decrease to kinetic rate constants

Cited by 11 publications

References 51 publications

Gas‐Phase Ion‐Molecule Interactions in a Collision Reaction Cell with ICP‐MS/MS: Investigations with CO2 as the Reaction Gas

Gas‐Phase Ion‐Molecule Interactions in a Collision Reaction Cell with ICP‐MS/MS: Investigations with CO2 as the Reaction Gas

N2O as a Universal Reaction Gas to Overcome Spectral Interference in Determining Metal Impurities in Mg(TFSI)2 Electrolytes for Rechargeable Magnesium Batteries by Inductively Coupled Plasma Tandem Mass Spectrometry

Classification of Chemical Elements in the Reaction Cell of ICP-MS Based on the Affinities with Sulfur, Oxygen, and Fluorine

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Product

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Gas‐Phase Ion‐Molecule Interactions in a Collision Reaction Cell with ICP‐MS/MS: Investigations with CO₂ as the Reaction Gas

Gas‐Phase Ion‐Molecule Interactions in a Collision Reaction Cell with ICP‐MS/MS: Investigations with CO₂ as the Reaction Gas

N₂O as a Universal Reaction Gas to Overcome Spectral Interference in Determining Metal Impurities in Mg(TFSI)₂ Electrolytes for Rechargeable Magnesium Batteries by Inductively Coupled Plasma Tandem Mass Spectrometry