Ion release and enamel remineralizing potential of miswak, propolis and chitosan nano-particles based dental varnishes

Wassel, Mariem; Sherief, Dalia I.

doi:10.1016/j.pdj.2018.12.004

Cited by 21 publications

(15 citation statements)

References 22 publications

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“…The Anticariogenic Effect of Miswak (Silvadora Persica) and Grape Seed Extract (389) Miswak increased enamel radiodensity, this was supported by previous studies (12,13) . Which showed that, miswak precipitate a polysaccharides layer on enamel surface protecting it and increasing its resistance to acid challenges.…”

Section: Discussionsupporting

confidence: 68%

The Anticariogenic Effect of Miswak (Silvadora Persica) and Grape Seed Extract

Khoriba¹,

Niazy²,

Sharkawy³

2022

ADJ-for Girls

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Purpose: To evaluate the effect of Miswak and Grape seed extract (GSE) on enamel and dentine subjected to artificial acid challenge in-vitro. Materials and Methods: A total of thirty sound freshly extracted sound human permanent periodontally affected upper molars were used. 30 enamel specimens were cut from the buccal surface of the teeth and 30 dentin specimens were cut from the cervical root area. All specimens were polished to obtain a flat polished surface. Ethanolic miswak extract was prepared by percolation method. Solutions of 10% ethanolic miswak extract, 6.5% Grape seed extract and 0.05% sodium fluoride were prepared. Specimens were divided into two groups (n=30); enamel and dentin. Each group was further divided into three sub-groups (n=10) according to the material used. Group1; treated with 10% ethanolic miswak extract solution. Group2; treated with 6.5% GSE solution. Group3; treated with 0.05% sodium fluoride solution (positive control). Specimens were individually subjected to alternative treatment/pH cycling regimen for 7 days. Radiodensity (change in mineral content) for each enamel and dentine specimen was assessed before and after pH cycling using digital radiography. Data were statistically analyzed; the significance level was set at p ≤0.05. Results: Miswak and GSE showed a high percent gain in enamel and dentine radiodensity compared to fluoride. Conclusion: Miswak and GSE are beneficial to both enamel and dentin through increasing their resistance to acid attacks.

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Section: Discussionsupporting

confidence: 68%

The Anticariogenic Effect of Miswak (Silvadora Persica) and Grape Seed Extract

Khoriba¹,

Niazy²,

Sharkawy³

2022

ADJ-for Girls

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“… 21 It has been researched extensively in the field of medicine and dentistry and has many clinical applications. 22 …”

Section: Discussionmentioning

confidence: 99%

Efficacy of propolis in remineralising artificially induced demineralisation of human enamel - An in-vitro study

Ali

Farooq

Bugshan

et al. 2021

Journal of Taibah University Medical Sciences

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Objective In this in vitro study, we aimed to analyse the enamel-remineralisation potential of propolis. Materials and methods Twenty enamel blocks (N = 20) were randomly divided into two groups (n = 10). In group 1 (control), enamel blocks were brushed with artificial saliva (AS). In group 2, they were brushed with propolis oil. All the blocks were demineralised by exposing them to 6 wt% citric acid (pH: 2.2) for 5 min. Brushing was performed inside a tooth brushing simulation machine with manual toothbrushes. Each sample received 5,000 linear strokes. Surface microhardness analysis was performed for each sample at three time intervals (pre-demineralisation or baseline, post-demineralisation, and post-remineralisation) to obtain the Vickers hardness numbers (VHNs). Results An enhancement in the microhardness of the enamel samples was observed after brushing with propolis oil when compared with brushing using AS alone. In group 1 (control group), the mean baseline VHN was 583.66. It decreased to 116.23 after demineralisation and increased to 184.02 after remineralisation. The mean baseline VHN of group 2 was 506.91. It decreased to 317.60 after demineralisation and increased to 435.19 after remineralisation. The VHN values of both the groups revealed statistically significant differences ( p < 0.05) in inter-group and intra-group comparisons. Conclusion Brushing of enamel blocks with propolis led to a greater enhancement in their microhardness levels when compared with the control group. Future studies are essential to validate the exact mechanism of the beneficial effects of propolis on enamel.

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“…Chitosan is often used as a carrier for targeted drug delivery, to sustain drug effects at a subcellular scale, to achieve cellular targets with high accuracy, to achieve maximum therapeutic effect, and to decrease adverse effects [ 15 , 16 , 17 ]. In this approach, active drug substances are dissolved, entrapped, or encapsulated and absorbed or attached to the drug carriers [ 16 , 18 ]. Cationic CS can be electrostatically adsorbed with mucin carboxyl groups on the mucosal and enamel surface, in order to stay in the oral cavity for more than 6 h, and the film-forming ability of CS makes the drugs or biomolecules it is carrying release slowly [ 3 , 4 , 18 , 19 ].…”

Section: Application Of Nano-cs As Drug Carriers In Oral Soft Tissue Diseasesmentioning

confidence: 99%

“…In this approach, active drug substances are dissolved, entrapped, or encapsulated and absorbed or attached to the drug carriers [ 16 , 18 ]. Cationic CS can be electrostatically adsorbed with mucin carboxyl groups on the mucosal and enamel surface, in order to stay in the oral cavity for more than 6 h, and the film-forming ability of CS makes the drugs or biomolecules it is carrying release slowly [ 3 , 4 , 18 , 19 ]. When the pH of the oral environment is lower than 6.5 (the ionization constant of CS), CS can dissolve in water and release any drug or bioactive molecule it is carrying [ 20 ].…”

Section: Application Of Nano-cs As Drug Carriers In Oral Soft Tissue Diseasesmentioning

confidence: 99%

“…Nano-CS containing fluoride ions is added to mouthwash water, so that fluoride ions can be slowly released onto the surface of demineralized tooth tissue for extended periods, to promote remineralization [ 94 ]. Small-sized nano-CS (1−100 nm) is highly reactive, with better ionic exchange than that of large-sized nano-CS, to form fluorapatite with better acid-resisting ability [ 18 , 95 ].…”

Section: Application Of Nano-cs In Dental Hard Tissue Remineralizationmentioning

confidence: 99%

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The Application of Chitosan Nanostructures in Stomatology

2021

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Chitosan (CS) is a natural polymer with a positive charge, a deacetylated derivative of chitin. Chitosan nanostructures (nano-CS) have received increasing interest due to their potential applications and remarkable properties. They offer advantages in stomatology due to their excellent biocompatibility, their antibacterial properties, and their biodegradability. Nano-CSs can be applied as drug carriers for soft tissue diseases, bone tissue engineering and dental hard tissue remineralization; furthermore, they have been used in endodontics due to their antibacterial properties; and, finally, nano-CS can improve the adhesion and mechanical properties of dental-restorative materials due to their physical blend and chemical combinations. In this review, recent developments in the application of nano-CS for stomatology are summarized, with an emphasis on nano-CS’s performance characteristics in different application fields. Moreover, the challenges posed by and the future trends in its application are assessed.

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Ion release and enamel remineralizing potential of miswak, propolis and chitosan nano-particles based dental varnishes

Cited by 21 publications

References 22 publications

The Anticariogenic Effect of Miswak (Silvadora Persica) and Grape Seed Extract

The Anticariogenic Effect of Miswak (Silvadora Persica) and Grape Seed Extract

Efficacy of propolis in remineralising artificially induced demineralisation of human enamel - An in-vitro study

The Application of Chitosan Nanostructures in Stomatology

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