Ion Sequestration, Solvent Extraction and Antimicrobial Behavior of Quinoline Functionalized Chitosan

Gaidhane, Mahesh K.; Rahatgaonkar, Anjali M.; Tiwari, Ashutosh; Chorghade, Mukund S.

doi:10.1007/s10904-010-9422-1

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…Chitosan, a non-toxic biopolymer can be utilized to prepare precious metal nanocomposites [24][25][26][27][28][29][30][31][32] because it acts as dispersant and avoids metal particles agglomeration [33][34][35][36][37][38]. Bhumkar et al have reported chitosan stabilized gold nanoparticles as a carrier for transmucosal delivery of insulin [39].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis Of Gold Nanoparticles For controlled Delivery

Malathi¹,

Balakumaran²,

Kalaichelvan³

et al. 2013

Adv. Mater. Lett.

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Gold nanoparticles (AuNPs) have been synthesized by green method using chitosan as a reducing/capping agent. We designed a biocompatible carrier for controlled release of hydrophobic drugs. The designed carrier was prepared by using single oil-inwater (O/W) emulsion. The resulting AuNPs were characterized by UV-Vis spectroscopy (UV-Vis) and Fourier transform infrared spectroscopy (FTIR). The transmission electron microscopy (TEM) studies indicate the spherical nature of drug loaded nanoparticles with the size of 50nm while the average particle size of AuNPs is found to be 2-3nm. The chitosan capped AuNPs showed a surface plasmon resonance at 526nm. The FTIR spectra suggest that the amine group is mainly responsible for the reduction of tetrachloroauric acid and capping the AuNPs. The controlled release of rifampicin (RIF) was investigated by in vitro studies using phosphate buffer saline (PBS) at pH=7.4. The loading efficiency of drug molecule was found to be 71%. The encapsulated drugs were released at 37 °C temperature. The results have been fit into various mechanistic models and it is found that the Higuchi model fits in to the release behavior of RIF. Further, the antibacterial activity of RIF loaded nanoparticles was examined by Gram +ve (bacillus subtils) and Gram -ve (Pseudomonas aeruginosa) bacteria. The application of similar drug loaded nanocarrier for treating other diseases like cancer can also be investigated.

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Section: Introductionmentioning

confidence: 99%

Green Synthesis Of Gold Nanoparticles For controlled Delivery

Malathi¹,

Balakumaran²,

Kalaichelvan³

et al. 2013

Adv. Mater. Lett.

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“…Chitosan and its derivatives have been widely used in different fields, such as medicine, pharmaceutical industry, the food industry, cosmetics, water treatment, tissue engineering, as well as gene therapy and agriculture; for example, as water disinfectant, films and blends for biodegradable packaging materials, pesticides, antibacterial and antifungal materials, paper coatings, flame retardants, coagulants, antioxidants, and as carriers in drug delivery systems . Different chemical modifications have been reported to increase the antibacterial activity of chitosan, to alter the physicochemical properties for biomedical applications with lower toxicity, to develop functional materials which can be used as source of natural antioxidants, or as depolluting agent for metal ions; all these properties depend on the degree of substitution . In order to improve chitosan properties, attention has been recently paid to chitosan chemical modification by introducing, for example, quaternary ammonium moieties into the polymer backbone, which represents one of the most promising strategies for antimicrobial materials preparation .…”

Section: Introductionmentioning

confidence: 99%

EDC‐Mediated Grafting of Quaternary Ammonium Salts onto Chitosan for Antibacterial and Thermal Properties Improvement

Oyervides–Muñoz

Avérous

Sosa‐Santillán

et al. 2019

Macro Chemistry & Physics

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The present study provides antibacterial and thermal improvements of chitosan‐based systems through chemical modification with different quaternary ammonium salts using 1‐ethyl‐3‐(3‐dimethylaminopropyl) carbodiimide (EDC) as mediator. Three different ammonium salts with a carboxylic acid end group are synthesized through a quaternization reaction between bromohexanoic acid and the respective tertiary amines (quinoline, N,N‐dimethylbenzylamine and pyridine). They are then chemically grafted along the chitosan backbone using EDC as a carboxyl activating agent for the coupling with the primary amine groups. This allows three different chitosan derivatives to be obtained: Quinolinium‐Chitosan (QA‐Cs), Benzalkonium‐Chitosan (BK‐Cs), and Pyridinium‐Chitosan (PA‐Cs), respectively. The chemical structures are characterized by 1H NMR analysis. The thermal stability is analyzed by thermogravimetric analysis. Antibacterial efficiencies of chitosan derivatives against Pseudomonas aeruginosa and Staphylococcus aureus strains are determined. All the chitosan derivatives show negligible antibacterial activity against Gram‐positive S. aureus strain. However, the antibacterial activity against Gram‐negative P. aeruginosa strain is significantly improved.

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Preparation and characterization of a novel pH-response dietary fiber: Chitosan-coated konjac glucomannan

Zhao

Jin

et al. 2015

Carbohydrate Polymers

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Ion Sequestration, Solvent Extraction and Antimicrobial Behavior of Quinoline Functionalized Chitosan

Cited by 4 publications

References 23 publications

Green Synthesis Of Gold Nanoparticles For controlled Delivery

Green Synthesis Of Gold Nanoparticles For controlled Delivery

EDC‐Mediated Grafting of Quaternary Ammonium Salts onto Chitosan for Antibacterial and Thermal Properties Improvement

Preparation and characterization of a novel pH-response dietary fiber: Chitosan-coated konjac glucomannan

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