Ion/Water Channels for Embryo Implantation Barrier

Liu, Xinmei; Zhang, Dan; Wang, Tingting; Sheng, Jian‐Zhong; Huang, He‐Feng

doi:10.1152/physiol.00039.2013

Cited by 10 publications

(8 citation statements)

References 142 publications

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“…The specific functional roles of such ion channels are not yet fully understood, however evidence is emerging that some of these ion channels may be key players in the processes occurring during embryo implantation (Ruan et al, 2014;Liu et al, 2014). The majority of ion channels in the endometrium are tightly regulated by ovarian hormones, or factors from the implanting embryo.…”

Section: Ion Channelsmentioning

confidence: 99%

“…The majority of ion channels in the endometrium are tightly regulated by ovarian hormones, or factors from the implanting embryo. Ion channel proteins exhibit their classical role in establishing a resting membrane potential, are regulated by steroid hormones (such as estrogen and progesterone), and function as a signal cascade initiator via stimulation from their ligand (Liu et al, 2014). For example, interplay between the cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC), as well as potassium (K 1 ) channels, are vital in regulating uterine electrolyte and fluid transport.…”

Section: Ion Channelsmentioning

confidence: 99%

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Molecular mechanisms of membrane interaction at implantation

Davidson

Coward

2016

Birth Defects Research Pt C

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Successful pregnancy is dependent upon the implantation of a competent embryo into a receptive endometrium. Despite major advancement in our understanding of reproductive medicine over the last few decades, implantation failure still occurs in both normal pregnancies and those created artificially by assisted reproductive technology (ART). Consequently, there is significant interest in elucidating the etiology of implantation failure. The complex multistep process of implantation begins when the developing embryo first makes contact with the plasma membrane of epithelial cells within the uterine environment. However, although this biological interaction marks the beginning of a fundamental developmental process, our knowledge of the intricate physiological and molecular processes involved remains sparse. In this synopsis, we aim to provide an overview of our current understanding of the morphological changes which occur to the plasma membrane of the uterine endothelium, and the molecular mechanisms that control communication between the early embryo and the endometrium during implantation. A multitude of molecular factors have been implicated in this complex process, including endometrial integrins, extracellular matrix molecules, adhesion molecules, growth factors, and ion channels. We also explore the development of in vitro models for embryo implantation to help researchers investigate mechanisms which may underlie implantation failure. Understanding the precise molecular pathways associated with implantation failure could help us to generate new prognostic/diagnostic biomarkers, and may identify novel therapeutic targets.

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Section: Ion Channelsmentioning

confidence: 99%

Section: Ion Channelsmentioning

confidence: 99%

Molecular mechanisms of membrane interaction at implantation

Davidson

Coward

2016

Birth Defects Research Pt C

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“…Accordingly, this coexpression of CFTR and ENaC in the uterus has significant implications for embryo implantation. If brief, enhancing the absorptive activity of the endometrial epithelium could facilitate blastocyst implantation (34). SGK1 has been reported to increase CFTR abundance in human airway epithelia cells (35).…”

Section: Involvement Of Sgk1 In Implantationmentioning

confidence: 99%

Involvement of serum glucocorticoid‐regulated kinase 1 in reproductive success

Lou

Mao

et al. 2016

FASEB j.

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Reproductive processes, in particular events that concern pregnancy, are fine-tuned to produce offspring. Reproductive success is of prime importance for the survival of every species. The highly conserved and ubiquitously expressed serum glucocorticoid-regulated kinase 1 (SGK1) was first implicated in infertility as a regulator of a Na channel. In this review, we emphasize the prominent role of SGK1 during early pregnancy: 1) balancing uterine luminal fluid secretion and reabsorption to aid blastocyst adhesion and to import nutrients and energy; 2) transducing signals from the blastocyst to the receptive endometrium; 3) inducing multiple genes that are involved in uterine receptivity and trophoblast invasion; 4) regulating cell differentiation and antioxidant defenses at the fetomaternal interface; and 5) contributing to the proliferation and survival of decidual stromal cells. Accordingly, SGK1 coordinates many cellular processes that are crucial to reproductive activities. Aberrant expression or function of SGK1 results in implantation failure and early pregnancy loss. Further investigation of the molecular mechanisms of the function of SGK1 might provide novel diagnostic tools and interventions for reproductive complications.-Lou, Y., Hu, M., Mao, L., Zheng, Y., Jin, F. Involvement of serum glucocorticoid-regulated kinase 1 in reproductive success.

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“…The downregulation of claudins is clearly associated to modifications in ion and water interchange 34 and it has been recently shown that steroid hormones-regulated ion/water channel proteins are important for embryo implantation. 35 The expression of integrin αv3 was lower in women who became pregnant in comparison with those that did not. This result was somehow surprising but the crucial issue is ¿what is considered as an adequate integrin αvβ3 expressions?…”

mentioning

confidence: 96%

Progesterone Receptor Phosphorylation is Associated to Claudin 1and 6 Expression and Pregnancy Success in ART-Treated Women

Paz-Martínez¹,

Moreno-Barragán²,

Godoy-Morales³

et al. 2015

EMIJ

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The success in infertility hormonal treatments and achieving a successful pregnancy is of great importance among infertile couples. Consequently the need to define new endometrial markers to evaluate the real impact of treatments is pressing. Since blastocyst implantation in a functional endometrium in the so-called "window of receptivity" is strongly associated to progesterone, our aim was to correlate the level of expression of progesterone-dependent claudins-1, -2, -3, -4, -5 and -6, αvβ3 integrin, LIF and progesterone receptor with pregnancy success in endometrial biopsies of primary infertile women. Endometrium was obtained during the secretory phase of the menstrual cycle from eight healthy and fertile women and 48 primary infertile women aged 30-47 years old being treated in the Infertility Clinic, Hospital "Angeles" del Pedregal, México.Immunohistochemical analysis of the biopsies was performed with monoclonal and polyclonal antibodies reactive to claudins-1 to -6, LIF, αvβ3 integrin, progesterone receptor (PR) and its phosphorylated form (pPR). Sera obtained the same day of the biopsy were used to determine anti-Mullerian hormone concentration. The results showed that less claudin-1 and -6, LIF and integrin αvβ3 abundance together with pPR was associated with successful pregnancy in 20 of the women, the remaining 28 did not became pregnant but interestingly pPR could not be detected. In conclusion the examination of claudin-1 and -6 together with the phosphorylation of PR in the endometrial biopsies of infertile women under ART protocols will help predict greater successful pregnancy.

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Ion/Water Channels for Embryo Implantation Barrier

Cited by 10 publications

References 142 publications

Molecular mechanisms of membrane interaction at implantation

Molecular mechanisms of membrane interaction at implantation

Involvement of serum glucocorticoid‐regulated kinase 1 in reproductive success

Progesterone Receptor Phosphorylation is Associated to Claudin 1and 6 Expression and Pregnancy Success in ART-Treated Women

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