Ionic Colloidal Molding as a Biomimetic Scaffolding Strategy for Uniform Bone Tissue Regeneration

Abstract

Inspired by the highly ordered nanostructure of bone, nanodopant composite biomaterials are gaining special attention for their ability to guide bone tissue regeneration through structural and biological cues. However, bone malformation in orthopedic surgery is a lingering issue, partly due to the high surface energy of traditional nanoparticles contributing to aggregation and inhomogeneity. Recently, carboxyl-functionalized synthetic polymers have been shown to mimic the carboxyl-rich surface motifs of non-collagenous proteins in stabilizing hydroxyapatite and directing intrafibrillar mineralization in-vitro. Based on this biomimetic approach, it is herein demonstrated that carboxyl functionalization of poly(lactic-co-glycolic acid) can achieve great material homogeneity in nanocomposites. This ionic colloidal molding method stabilizes hydroxyapatite precursors to confer even nanodopant packing, improving therapeutic outcomes in bone repair by remarkably improving mechanical properties of nanocomposites and optimizing controlled drug release, resulting in better cell in-growth and osteogenic differentiation. Lastly, better controlled biomaterial degradation significantly improved osteointegration, translating to highly regular bone formation with minimal fibrous tissue and increased bone density in rabbit radial defect models. Ionic colloidal molding is a simple yet effective approach of achieving materials homogeneity and modulating crystal nucleation, serving as an excellent biomimetic scaffolding strategy to rebuild natural bone integrity.

Micro-Nano Bioactive Glass Particles Incorporated Porous Scaffold for Promoting Osteogenesis and Angiogenesis in vitro

“…Bone defects, caused by breaks, tumors, and traumas, bring great pressure to public health, and become an urgent problem to be resolved (Li et al, 2018a; Zheng et al, 2018). In recent years, bone tissue engineering scaffolds play a more and more important role in bone repair field due to the growing market demand (Xu et al, 2016; Zhao et al, 2018a), due to the drawbacks in autologous and allograft bone graft (Zhang et al, 2017). Bone scaffolds should have the ability to mobilize cells to reach the lesion place after implanted, until the regenerated tissue is enough stabilized to support the native bone.…”

Construction of versatile multilayered composite nanoparticles from a customized nanogel template

“…However, collagen carriers require excessive drug dosages due to low loading efficiency [25] , while ceramics such as β-TCP and HA do not meet the mechanical requirements to contour bone surfaces [24] . Several ceramic/polymer composites have been recently designed to overcome poor loading capacity and mechanical properties, yet release kinetics are still inadequate due to a large initial burst release and poorly controlled slow release thereafter [26] , [27] , [28] , [29] .…”

Optimized Synthesis of Biodegradable Elastomer PEGylated Poly(glycerol sebacate) and Their Biomedical Application

“…Besides, porous elastomeric grafts composed of PGS and PCL nanofibers have been investigated to promote the degradation behavior in arterial remodeling [19]. However, such PGS composites by a physical blend approach are prone to phase separation and thus triggering inhomogeneity and instability of the properties such as mechanical stiffness and bioactivity [20].…”