Ionic liquid-based slab optical waveguide sensor for the detection of ammonia in human breath

Gao, Lifang; Yang, Xu; Shu, Yang; Chen, Xuwei; Wang, Jianhua

doi:10.1016/j.jcis.2017.10.114

Cited by 49 publications

(22 citation statements)

References 40 publications

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“…One of the cheapest and very effective methods to increase the detection limit is by using a gas preconcentration structure [ 29 , 30 ]. In addition, scientists are carrying out research for developing a single gas sensor which could cover the exhaled acetone range [ 31 ] and, crucially, work at room temperature [ 32 , 33 , 34 , 35 ], and includes microwave-based [ 36 , 37 ] and optical-based sensors [ 38 , 39 , 40 ]. That makes the process noninvasive, real-time, and less expensive compared to the traditional medical diagnosis methods.…”

Section: Introductionmentioning

confidence: 99%

Sensors for Enhanced Detection of Acetone as a Potential Tool for Noninvasive Diabetes Monitoring

Rydosz

2018

Sensors

135

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Measurement of blood-borne volatile organic compounds (VOCs) occurring in human exhaled breath as a result of metabolic changes or pathological disorders is a promising tool for noninvasive medical diagnosis, such as exhaled acetone measurements in terms of diabetes monitoring. The conventional methods for exhaled breath analysis are based on spectrometry techniques, however, the development of gas sensors has made them more and more attractive from a medical point of view. This review focuses on the latest achievements in gas sensors for exhaled acetone detection. Several different methods and techniques are presented and discussed as well.

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Section: Introductionmentioning

confidence: 99%

Sensors for Enhanced Detection of Acetone as a Potential Tool for Noninvasive Diabetes Monitoring

Rydosz

2018

Sensors

135

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“…Bromothymol blue (BTB) is a pH-sensitive synthetic dye that is used extensively in indicators [23,24,25]. As shown in Figure 1, it is negatively charged in alkaline solution.…”

Section: Introductionmentioning

confidence: 99%

In-Situ pH-Sensitive Fibers via the Anchoring of Bromothymol Blue on Cellulose Grafted with Hydroxypropyltriethylamine Groups via Adsorption

et al. 2018

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In-situ pH-sensitive cellulose fibers (IS-pH-SCF) were prepared by anchoring bromothymol blue (BTB) onto cellulose fibers (CF) modified with hydroxypropyltriethylamine (HPTTL) groups. Fourier transform infrared and X-ray photoelectron spectrum analyses demonstrated that the HPTTL groups were grafted onto the CF. X-ray diffraction proved that cellulose I in the CF transformed into cellulose II after quaternization. Scanning electron microscopy suggested that the quaternized CF (QCF) surface was clean and uniformly ridged. The adsorption of BTB onto QCF was carried out via batch adsorption experiments. A kinetic study illustrated that the adsorption was a spontaneous process and described well by pseudo-second-order, Freundlich and Temkin isotherms. The activation energy for the BTB adsorption onto QCF was 52.89 kJ/mol, which proved that the BTB adsorption onto QCFs was chemically controlled. The pH response demonstrated that the IS-pH-SCF was highly sensitive to pH, with an obvious color change for pH 4 to 8. The release tests showed that BTB was anchored on QCFs and that no BTB was released. IS-pH-SCF has a potential use for indicating pH changes in food.

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“…More recently, optical and surface plasmon resonance (SPR)-based sensors have introduced novel results in the applications of biosensors and biomarkers based on levels of VOCs in patient respiration [9][10][11]. Optical biosensors are characterized by high performance, inexpensive, and compact design which can be inserted with a lab-on-a-chip device [12,13].…”

Section: Introductionmentioning

confidence: 99%

Detection of isoprene traces in exhaled breath by using photonic crystals as a biomarker for chronic liver fibrosis disease

Mehaney

Elsayed

Ahmed

2021

Preprint

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Detection of blood-carried volatile organic compounds (VOCs) existing in the exhaled breath of human is an attractive research point for noninvasive diagnosis of diseases. In this research, we introduce a novel application of photonic crystals (PCs) for the detection of isoprene traces in the exhaled breath as a biomarker for liver fibrosis. This idea is introduced for the first time according to the best of our knowledge. The proposed sensor structure is a one-dimensional (1D) PC constructed from a multilayer stack of two dielectric materials covered with an air cavity layer filled with the dry exhaled breath (DEB) and a thin metallic layer of Au is attached on the top surface. Hence, the proposed sensor is configured as, [prism/Au/air cavity/(GaN/SiO2)10]. The transfer matrix method and the Drude model are adopted to calculate the numerical simulations and reflection spectra of the design. The essential key for sensing isoprene levels is the resonant optical Tamm plasmon (TP) states within the photonic bandgap. The obtained numerical results are promising such as high sensitivity (S) of 0.321 nm/ppm or 278720 nm/RIU. This technique can be reducing the risk of infection during the taking of blood samples by syringe. Also, it can prevent the pain of patients. Finally, this work opens the door for the detection of many diseases by analyzing the breaths of patients based on photonic crystals.

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Ionic liquid-based slab optical waveguide sensor for the detection of ammonia in human breath

Cited by 49 publications

References 40 publications

Sensors for Enhanced Detection of Acetone as a Potential Tool for Noninvasive Diabetes Monitoring

Sensors for Enhanced Detection of Acetone as a Potential Tool for Noninvasive Diabetes Monitoring

In-Situ pH-Sensitive Fibers via the Anchoring of Bromothymol Blue on Cellulose Grafted with Hydroxypropyltriethylamine Groups via Adsorption

Detection of isoprene traces in exhaled breath by using photonic crystals as a biomarker for chronic liver fibrosis disease

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