Ionic-Liquid-Mediated Extraction and Separation Processes for Bioactive Compounds: Past, Present, and Future Trends

Ventura, Sónia P. M.; Silva, Francisca A. e; Quental, Maria V.; Mondal, Dibyendu; Freire, Mara G.; Coutinho, João A. P.

doi:10.1021/acs.chemrev.6b00550

Cited by 800 publications

(443 citation statements)

References 380 publications

(1,462 reference statements)

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“…carbohydrates, pigments, lipids). Therefore, to provide a realistic scenario, investigations using IL‐ATPSs need to focus on the fractionation of these compounds from complex matrices …”

Section: Introductionmentioning

confidence: 99%

Selective and mild fractionation of microalgal proteins and pigments using aqueous two‐phase systems

Ruiz

Emmery

Wijffels

et al. 2018

J of Chemical Tech & Biotech

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BACKGROUNDMicroalgal biomass is generally used to produce a single product instead of valorizing all of the cellular components. The biomass production and downstream processes are too expensive if only one product is valorized. A new approach was proposed for the simultaneous and selective partitioning of pigments and proteins from disrupted Neochloris oleoabundans cultivated under saline and freshwater conditions.RESULTSAn aqueous two‐phase system composed of polyethylene glycol and cholinium dihydrogen phosphate selectively separated microalgal pigments from microalgal proteins. 97.3 ± 1.0% of lutein and 51.6 ± 2.3% of chlorophyll were recovered in the polymer‐rich phase. Simultaneously, up to 92.2 ± 2.0% of proteins were recovered in a third phase (interface) in between the aqueous phases (interface). The recovered proteins, including Rubisco with a molecular weight of ∼560 kDa, seem to be intact and pigments did not suffer degradation, demonstrating the mildness of this system for fractionating microalgal biomolecules.CONCLUSIONThe ability of aqueous two‐phase systems (ATPSs) to simultaneously and efficiently fractionate different biomolecules in a mild manner from disrupted microalgae is demonstrated. This is an important step towards the development of a multiproduct microalgae biorefinery. © 2018 The Authors. Journal of Chemical Technology & Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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“…carbohydrates, pigments, lipids). Therefore, to provide a realistic scenario, investigations using IL‐ATPSs need to focus on the fractionation of these compounds from complex matrices …”

Section: Introductionmentioning

confidence: 99%

Selective and mild fractionation of microalgal proteins and pigments using aqueous two‐phase systems

Ruiz

Emmery

Wijffels

et al. 2018

J of Chemical Tech & Biotech

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“…[1][2][3][4][5][6][7] Thep roperties of ILs are governed by as ubtle balance of Coulombic interactions,h ydrogen bonding, and dispersion forces. [1][2][3][4][5][6][7] Thep roperties of ILs are governed by as ubtle balance of Coulombic interactions,h ydrogen bonding, and dispersion forces.…”

mentioning

confidence: 99%

Spectroscopic Evidence for an Attractive Cation–Cation Interaction in Hydroxy‐Functionalized Ionic Liquids: A Hydrogen‐Bonded Chain‐like Trimer

et al. 2018

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We address the formation of hydrogen bonded domains among the cationic constituents of the ionic liquid (IL) 1-(3-hydroxypropyl)pyridinium tetrafluoroborate [HPPy] [BF 4 ]b ym eans of cryogenic ion vibrational predissociation spectroscopyofcold (ca. 35 K) gas-phase cluster ions and quantum chemistry.S pecifically,a nalysis of the OH stretching bands reveals ac hain-like OH···OH···OH···BF 4 À binding motif involving the three cations in the cationic quinary cluster ion (HPPy + ) 3 (BF 4 À ) 2 .C alculations showt hat this cooperative H-bond attraction compensates for the repulsive Coulomb forces and results in stable complexes that successfully compete with those in which the OH groups are predominantly attached to the counter anions.O ur combined experimental and theoretical approach provides insight into the cooperative effects that lead to the formation of hydrogen bonded domains involving the cationic constituents of ILs.

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“…In addition to the use of ionic liquids in processing lignocellulosic materials, ILs have been used in applications such as extraction of essential oils, lipids, hydrophobic compounds, proteins, amino acids, nucleic acids and these reports have been reviewed recently . Mehta et al.…”

Section: Miscellaneous Applications Of Ionic Liquids In Biomass Procementioning

confidence: 99%

Ionic Liquids in Biomass Processing

Amarasekara

2018

Israel Journal of Chemistry

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The ionic liquids have emerged as new solvents and catalysts for processing biomass to value added chemicals and fuels. This review will present the recent developments in applications of ionic liquids in lignocellulosic biomass pretreatments, depolymerization, biodiesel synthesis, dehydration of carbohydrates to renewable feedstock chemicals as well as further transformations of biomass derived feedstocks such as furfural, 5‐hydroxymethylfurfural and levulinic acid to value added chemicals. In addition, the recycling of ionic liquids used in biomass processing is also discussed in the review.

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Ionic-Liquid-Mediated Extraction and Separation Processes for Bioactive Compounds: Past, Present, and Future Trends

Cited by 800 publications

References 380 publications

Selective and mild fractionation of microalgal proteins and pigments using aqueous two‐phase systems

Selective and mild fractionation of microalgal proteins and pigments using aqueous two‐phase systems

Spectroscopic Evidence for an Attractive Cation–Cation Interaction in Hydroxy‐Functionalized Ionic Liquids: A Hydrogen‐Bonded Chain‐like Trimer

Ionic Liquids in Biomass Processing

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