Ionic liquids as mobile phase additives and immobilized on stationary phases in liquid chromatography

Ruiz-Ángel, M.J.; Carda‐Broch, Samuel; García-Álvarez-Coque, M.C.

doi:10.1016/b978-0-12-823334-4.00003-5

Cited by 4 publications

(2 citation statements)

References 109 publications

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“…The polysaccharide derivatives have been immobilized on a silica matrix and are frequently utilized as the chiral stationary phase to address this flaw. This method of immobilizing the polymeric chiral selectors on the silica support is thought to be effective in granting the CSP a broad range of solvent compatibility, increasing the number of solvents that can be utilized as [70,71].…”

Section: Hplc For Chiral Drugs Analysismentioning

confidence: 99%

Emerging Developments in Separation Techniques and Analysis of Chiral Pharmaceuticals

Al-Sulaimi,

Kushwah,

Abdullah Alsibani

et al. 2023

Molecules

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Chiral separation, the process of isolating enantiomers from a racemic mixture, holds paramount importance in diverse scientific disciplines. Using chiral separation methods like chromatography and electrophoresis, enantiomers can be isolated and characterized. This study emphasizes the significance of chiral separation in drug development, quality control, environmental analysis, and chemical synthesis, facilitating improved therapeutic outcomes, regulatory compliance, and enhanced industrial processes. Capillary electrophoresis (CE) has emerged as a powerful technique for the analysis of chiral drugs. This review also highlights the significance of CE in chiral drug analysis, emphasizing its high separation efficiency, rapid analysis times, and compatibility with other detection techniques. High-performance liquid chromatography (HPLC) has become a vital technique for chiral drugs analysis. Through the utilization of a chiral stationary phase, HPLC separates enantiomers based on their differential interactions, allowing for the quantification of individual enantiomeric concentrations. This study also emphasizes the significance of HPLC in chiral drug analysis, highlighting its excellent resolution, sensitivity, and applicability. The resolution and enantiomeric analysis of nonsteroidal anti-inflammatory drugs (NSAIDs) hold great importance due to their chiral nature and potential variations in pharmacological effects. Several studies have emphasized the significance of resolving and analyzing the enantiomers of NSAIDs. Enantiomeric analysis provides critical insights into the pharmacokinetics, pharmacodynamics, and potential interactions of NSAIDs, aiding in drug design, optimization, and personalized medicine for improved therapeutic outcomes and patient safety. Microfluidics systems have revolutionized chiral separation, offering miniaturization, precise fluid control, and high throughput. Integration of microscale channels and techniques provides a promising platform for on-chip chiral analysis in pharmaceuticals and analytical chemistry. Their applications in techniques such as high-performance liquid chromatography (HPLC) and capillary electrochromatography (CEC) offer improved resolution and faster analysis times, making them valuable tools for enantiomeric analysis in pharmaceutical, environmental, and biomedical research.

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Section: Hplc For Chiral Drugs Analysismentioning

confidence: 99%

Emerging Developments in Separation Techniques and Analysis of Chiral Pharmaceuticals

Al-Sulaimi,

Kushwah,

Abdullah Alsibani

et al. 2023

Molecules

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“…Commonly used ionic liquids include 1‐ethyl‐3‐methyl‐ imidazolium, 1‐butyl‐3‐methyl‐ imidazolium, 1‐octyl‐3 methyl imidazolium, 1‐decyl‐3‐methyl imidazolium, 1‐dodecyl‐3‐methyl‐docecyl 1‐butyl‐2,3‐dimethylimidazolium tetrafluoroborate, N ‐butyl‐3‐methylpyridinium tetrafluoroborate, methyltrioctylammonium trifluoroacetate, 1‐butyl‐3‐methylimidazolium tetrafluoroborate, 1‐methyl‐3‐octyloxymethylimidazolium tetrafluoroborate l imidazolium and 3‐methyl‐1‐octylimidazolium tetrafluoroborate (Petruczynik, 2012; Ruiz‐Ángel et al, 2022).…”

Section: Effect Of Ionic Liquids As Mobile Phase Additivesmentioning

confidence: 99%

Retention behaviour of analytes in reversed‐phase high‐performance liquid chromatography—A review

V.¹,

Basuri²,

Sahini³

et al. 2022

Biomedical Chromatography

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The understanding of principles that drive the separation in reversed‐phase chromatography plays an important role in the prediction of the elution of solutes in RP‐HPLC. The separation in RP‐HPLC is based on the principle of adsorption and partition. In addition, the logP value, the pKa value of the drug and chromatographic parameters like mobile phase pH, buffer concentration, organic modifier and mobile phase additives also influence the retention and selectivity of the analyte. It was found that hydrophobic, electrostatic, hydrogen bonding and other specific interactions between the stationary phase and the solutes, along with the hydrophobicity of an analyte molecule (logP), modify the retention behaviour of the analytes. This article gives special attention to the influence of ionization and ion interaction on the separation of analytes. The drug molecules with different logP values containing protonated and deprotonated acids, bases and zwitterions are selected as examples and this article addresses various issues related to the method development, relationships between analyte retention and mobile phase pH and the pKa value of the analyte. The advances in this regard, with highlights on topics such as mechanisms of retention and various factors that influence the retention behaviour of analytes, are also updated with suitable examples.

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Greening Separation and Purification of Proteins and Peptides

Maráková

2024

J of Separation Science

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The increasing awareness of environmental issues and the transition to green analytical chemistry (GAC) have gained popularity among academia and industry in recent years. One of the principles of GAC is the reduction and replacement of toxic solvents with more sustainable and environmentally friendly ones. This review gives an overview of the advances in applying green solvents as an alternative to the traditional organic solvents for peptide and protein purification and analysis by liquid chromatography (LC) and capillary electrophoresis (CE) methods. The feasibility of using greener LC and CE methods is demonstrated through several application examples; however, there is still plenty of room for new developments to fully realize their potential and to address existing challenges. Thanks to the tunable properties of designer solvents, such as ionic liquids and deep eutectic solvents, and almost infinite possible mixtures of components for their production, it is possible that some new designer solvents could potentially surpass the traditional harmful solvents in the future. Therefore, future research should focus mainly on developing new solvent combinations and enhancing analytical instruments to be able to effectively work with green solvents.

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Ionic liquids as mobile phase additives and immobilized on stationary phases in liquid chromatography

Cited by 4 publications

References 109 publications

Emerging Developments in Separation Techniques and Analysis of Chiral Pharmaceuticals

Emerging Developments in Separation Techniques and Analysis of Chiral Pharmaceuticals

Retention behaviour of analytes in reversed‐phase high‐performance liquid chromatography—A review

Greening Separation and Purification of Proteins and Peptides

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