Ionic Liquids: New Opportunities for the Chemistry of Amino Acids, Peptides, and Pharmaceutical Compounds

Ionic Liquid Applications in Peptide Chemistry: Synthesis, Purification and Analytical Characterization Processes

“…[ 48 ] and are in detail in Section 2.2.3 , because larger peptide molecules prepared by ligation reactions are in the focus of that study. However, enzymatic acylation of smaller peptides has also been described by other groups, as can be exemplified by the lipase-catalyzed acylation of Lys-Ser x HCl with oleic acid carried out in either organic media (2-methyl-2-butanol) or an ionic liquid ([C 4 mim][PF 6 ]) [ 49 ]. Substrate conversion in this case was found to depend on peptide solubility which was improved in the IL.…”

Efficient Sustainable Tool for Monitoring Chemical Reactions and Structure Determination in Ionic Liquids by ESI‐MS

“…[ 7 – 10 ] Ionic liquids showed excellent results and recyclability for Heck reactions,[ 11 ] Friedel–Crafts-type transformations,[ 12 ] Michael additions,[ 13 ] hydroaminations of alkenes,[ 14 ] ring-closing metatheses[ 15 ] and many other important organic synthesis procedures. [ 16 ] Important to note, ionic liquids were proposed to be well-suitable “green” solvents for peptide synthesis[ 17 ] and biomass conversion. [ 10 ]…”