Ionic permeability changes as the basis of the thermal dependence of the resting potential in barnacle muscle fibres

Fischbarg, Jorge

doi:10.1113/jphysiol.1972.sp009886

Cited by 22 publications

(4 citation statements)

References 39 publications

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“…The Q10's found for the shifts along the frequency axis (2 to 3) are of the same order as generally measured for (bio)chemical processes of vertebrates (e.g. Fischbarg, 1972). Temperature effects on retinal signals of mammals, as far as available, are in general agreement with the goldfish data (Liitzow, 1970;Penn & Hagins, 1972).…”

Section: Discussionsupporting

confidence: 84%

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Influence of temperature on retinal ganglion cell response and e.r.g. of goldfish

Schellart¹,

Spekreijse²,

Berg³

1974

The Journal of Physiology

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To verify whether a relationship exists between temperature and spectral coding, as has been suggested on the basis of behavioural studies, photopic e.r.g. action spectra were recorded and the spectral coding of ganglion cells were determined as a function of temperature.8. The results point to a temperature invariance of both the photopic e.r.g. action spectra and the colour coding of ganglion cell responses.

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Section: Discussionsupporting

confidence: 84%

“…The Q10's found for the shifts along the frequency axis (2 to 3) are of the same order as generally measured for (bio)chemical processes of vertebrates (e.g. Fischbarg, 1972 (Liitzow, 1970;Penn & Hagins, 1972). That the cut-off frequencies of the amplitude characteristics of e.r.g.…”

Section: Discussionsupporting

confidence: 59%

Influence of temperature on retinal ganglion cell response and e.r.g. of goldfish

Schellart¹,

Spekreijse²,

Berg³

1974

The Journal of Physiology

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“…f u,cell is typically measured by using cell homogenates at high cell density (e.g., 50 million cells/ml; see Discussion below on the limitations of using a low cell density), and the value is usually much lower than that for f u,inc but is similar to that for f u,liver . f u,cell can also be measured with whole cells at 4°C with the correction of the pH-gradient effect (i.e., f u,cell = 1/partition coefficient at 4°C), where active processes by transporters and enzymes and membrane potentials are essentially shut down at low temperature (Dipolo and Latorre, 1972;Fischbarg, 1972). The f u,inc , on the contrary, is usually determined using cell homogenates or dead cells at lower cell densities, the same as under the incubation conditions for metabolic stability studies (e.g., 0.5-2 million cells/ml).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell Lines

et al. 2018

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Fraction unbound () of liver tissue, hepatocytes, and other cell types is an essential parameter used to estimate unbound liver drug concentration and intracellular free drug concentration. and are frequently measured in multiple species and cell types in drug discovery and development for various applications. A comparison study of 12 matrices for and of hepatocytes in five different species (mouse, rat, dog, monkey, and human), as well as of Huh7 and human embryonic kidney 293 cell lines, was conducted for 22 structurally diverse compounds with the equilibrium dialysis method. Using an average bioequivalence approach, our results show that the average difference in binding to liver tissue, hepatocytes, or different cell types was within 2-fold of that of the rat Therefore, we recommend using rat as a surrogate for liver binding in other species and cell types in drug discovery. This strategy offers the potential to simplify binding studies and reduce cost, thereby enabling a more effective and practical determination of for liver tissues, hepatocytes, and other cell types. In addition, under hepatocyte stability incubation conditions should not be confused with , as one is a diluted and the other is an undiluted Cell density also plays a critical role in the accurate measurement of.

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“…Thus, acclimation could produce certain fundamental changes in membrane composition, which may differentially influence the operation of channels for potassium, sodium, and chloride ions, as well as those concerned with leakage. Such a differential effect on the relative permeabilities of a membrane to different ions has been demonstrated in barnacles (Dipolo and Latorre, 1972;Fischbarg, 1972). Recently, it has been shown that the membrane potential can hyperpolarize beyond the potassium potential at high temperatures (White, 1983).…”

Section: Resting Potentialmentioning

confidence: 92%

The Effects of Temperature and Acclimation on Crustacean Nerve-Muscle Physiology

Stephens¹

1985

The Biological Bulletin

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Crustaceans, like most ectotherms, have body temperatures that are close to ambient. Although some animals live in constant warm conditions, most crustaceans live in environments with both short-and long-term temperature fluctuations. Rapid temperature changes generally produce changes in the properties of the nerve and muscle membranes. As a result increases in temperature generally cause a decrease in the effectiveness of neuromuscular transmission. This is offset by an increase in the amount of synaptic facilitation, an increase in axon firing frequencies, and in some motor axons the production of additional responses in the peripheral branches. Although these changes act to overcome temperature-induced decreases in muscle tension, little is known about how the intact animal utilizes these changes to produce coordinated movements at different temperatures.Long-term changes in thermal conditions alter the properties of the motor nerves and the muscles. This results in a shift in the temperature range over which there is optimal neuromuscular performance towards the acclimation temperature.

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Ionic permeability changes as the basis of the thermal dependence of the resting potential in barnacle muscle fibres

Cited by 22 publications

References 39 publications

Influence of temperature on retinal ganglion cell response and e.r.g. of goldfish

Influence of temperature on retinal ganglion cell response and e.r.g. of goldfish

Comparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell Lines

The Effects of Temperature and Acclimation on Crustacean Nerve-Muscle Physiology

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