Ionic substituted hydroxyapatite for bone regeneration applications: A review

Ressler, Antonia; Žužić, Andreja; Ivanišević, Irena; Kamboj, Nikhil; Ivanković, Hrvoje

doi:10.1016/j.oceram.2021.100122

Cited by 140 publications

(103 citation statements)

References 143 publications

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“…The properties and biomedical applications of the single crystalline phases are discussed elsewhere in detail. Ressler et al [32] comprehensively reviewed ion-substituted hydroxyapatites-including fluorapatite-and Pajor et al [33] highlighted the importance of F-doped apatite for dental regenerative applications because of its lower solubility in an acidic environment (like the mouth) as compared to pure hydroxyapatite. Calcium silicate bioceramics were also reviewed in a recent paper [34].…”

Section: Resultsmentioning

confidence: 99%

Foam-Replicated Diopside/Fluorapatite/Wollastonite-Based Glass–Ceramic Scaffolds

et al. 2022

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Implantation of three-dimensional (3D) bioactive glass-derived porous scaffolds is an effective strategy for promoting bone repair and regeneration in large osseous defect sites. The present study intends to expand the potential of a SiO2–P2O5–CaO–MgO–Na2O–CaF2 glass composition, which has already proven to be successful in regenerating bone in both animals and human patients. Specifically, this research work reports the fabrication of macroporous glass–ceramic scaffolds by the foam replica method, using the abovementioned bioactive glass powders as a parent material. The sinter-crystallization of the glass powder was investigated by hot-stage microscopy, differential thermal analysis, and X-ray diffraction. Scanning electron microscopy was used to investigate the pore–strut architecture of the resultant glass–ceramic scaffolds in which diopside, fluorapatite, and wollastonite crystallized during thermal treatment. Immersion studies in simulated body fluids revealed that the scaffolds have bioactive behavior in vitro; the mechanical properties were also potentially suitable to suggest use in load-bearing bone applications.

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Section: Resultsmentioning

confidence: 99%

Foam-Replicated Diopside/Fluorapatite/Wollastonite-Based Glass–Ceramic Scaffolds

et al. 2022

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“…This is in agreement with the other published literature. [81,82] Also, the decrease in the peak intensity can be due to the formation of stresses by the difference in the size of the dopant element and the main material element. However, these changes were minor, meaning that the concentration of dopants was low to have a more significant influence.…”

Section: Materials Analysis Using Diffraction (Maud)mentioning

confidence: 99%

Thermoluminescence dose–response of synthesized and doped hydroxyapatite: effect of formed crystal phases

Taghipour

Zolfagharpour

Daneshvar³

et al. 2022

Luminescence

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In this research work, pure and doped hydroxyapatite samples were synthesized using hydrolysis and hydrothermal methods to produce powder material. The crystal structure was carried out by producing data using the X-ray diffraction system and the Rietveld method using material analysis using diffraction software. Then the sample was irradiated with different radiation absorbed doses, and their thermoluminescence response was investigated from the dosimetry point of view. The results showed that the synthesis method, doping, and annealing temperature could significantly affect the crystal structure and thermoluminescence dosimetry response of hydroxyapatite samples, consequently. The results showed that the high-temperature annealing process and dopant could lead to the formation of the β-TCP crystal phase during or after the synthesis of hydroxyapatite, and the percentage of this formed phase increased when raising the temperature, and finally led to increase in the thermoluminescence response.

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“…Herein, two important CaP phases, HA and β-TCP will be detailed, which are processed through PBSLP. HA is well known for its substitution of various ions in its lattice structure [125] and has another edge in terms of advantages concerning bone regeneration since it demonstrates piezoelectric behavior which helps with the acceleration of the bone regeneration process [126]. The scaffolds fabricated with such kinds of materials usually are favored for open bone defects or nonload bearing applications [127].…”

Section: Calcium Phosphate (Cap) Based Ceramicsmentioning

confidence: 99%

Bioactive Ceramic Scaffolds for Bone Tissue Engineering by Powder Bed Selective Laser Processing: A Review

2021

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The implementation of a powder bed selective laser processing (PBSLP) technique for bioactive ceramics, including selective laser sintering and melting (SLM/SLS), a laser powder bed fusion (L-PBF) approach is far more challenging when compared to its metallic and polymeric counterparts for the fabrication of biomedical materials. Direct PBSLP can offer binder-free fabrication of bioactive scaffolds without involving postprocessing techniques. This review explicitly focuses on the PBSLP technique for bioactive ceramics and encompasses a detailed overview of the PBSLP process and the general requirements and properties of the bioactive scaffolds for bone tissue growth. The bioactive ceramics enclosing calcium phosphate (CaP) and calcium silicates (CS) and their respective composite scaffolds processed through PBSLP are also extensively discussed. This review paper also categorizes the bone regeneration strategies of the bioactive scaffolds processed through PBSLP with the various modes of functionalization through the incorporation of drugs, stem cells, and growth factors to ameliorate critical-sized bone defects based on the fracture site length for personalized medicine.

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Ionic substituted hydroxyapatite for bone regeneration applications: A review

Cited by 140 publications

References 143 publications

Foam-Replicated Diopside/Fluorapatite/Wollastonite-Based Glass–Ceramic Scaffolds

Foam-Replicated Diopside/Fluorapatite/Wollastonite-Based Glass–Ceramic Scaffolds

Thermoluminescence dose–response of synthesized and doped hydroxyapatite: effect of formed crystal phases

Bioactive Ceramic Scaffolds for Bone Tissue Engineering by Powder Bed Selective Laser Processing: A Review

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