Ionized and bound fluoride in resting and fermenting dental plaque and individual human caries experience

Agus, Helen M.; Un, Pauline S. H.; Cooper, Michael H.; Schamschula, R. G.

doi:10.1016/0003-9969(80)90063-1

Cited by 31 publications

(24 citation statements)

References 17 publications

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“…The fluoride concentration in plaque from resi dents in a HF area is reported to be significantly higher than in those in a LF area [Agus et al, 1980;Grobler et al, 1982], Duckworth et al [1987] investi gated salivary and plaque fluoride levels before and after rinsing with fluoride solutions and found an apparently linear relationship between saliva and plaque fluoride. Preliminary data from our labora tory indicate that after topical fluoride exposure, the fluoride concentration in plaque fluid remains ele vated for a prolonged period compared to mixed whole saliva [Vogel and Ekstrand, 1989].…”

Section: Discussionmentioning

confidence: 99%

Diurnal Fluoride Concentration in Whole Saliva in Children Living in a High- and a Low-Fluoride Area

Oliveby¹,

Twetman²,

Ekstrand³

1990

Caries Res

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Salivary fluoride concentrations were investigated in 12-year-old children living in areas with low (0.1 ppm) or high (1.2 ppm) fluoride concentration in the drinking water. Unstimulated whole saliva was collected from 27 children from the respective areas every 2nd hour for 46 h except during sleep. The mean salivary fluoride concentration was 0.32 ± 0.013 μmol/l (n = 419) in the low-fluoride (LF) area and 0.87 + 0.047 μmol/l (n = 401) in the high-fluoride (HF) area. No significant rhythm could be found for the diurnal variations in the mean or individual salivary fluoride concentrations. However, in the HF area the individual salivary fluoride concentrations fluctuated widely and randomly.

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Section: Discussionmentioning

confidence: 99%

Diurnal Fluoride Concentration in Whole Saliva in Children Living in a High- and a Low-Fluoride Area

Oliveby¹,

Twetman²,

Ekstrand³

1990

Caries Res

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“…This is particularly important if the inner, older plaque is considered to operate under anaerobic conditions [Imfeld and Lutz, 1980]. Plaque acid produced under anaerobic conditions is likely to favor the release of bound fluoride even from within bacterial cells [Agus et al, 1980]. It is clear from these data that the enamel itself can supply fluoride to the plaque and act as a reservoir [Fejerskov and Clarkson, 1996] which could potentially facilitate remineralization.…”

Section: Discussionmentioning

confidence: 99%

Fluoride Profiles in Dental Plaque in vivo Formed on Fluoride Pre–Treated Human Enamel

et al. 2000

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Using a novel device capable of generating plaque in vivo on a natural enamel substrate, it has been possible to determine fluoride profiles from the saliva–plaque interface towards the enamel surface. Fluoride profiles in dental plaques tended to fall from the saliva–plaque interface towards the enamel. The device also offered the possibility of examining fluoride distributions after pre–treatment of the enamel with fluoride in vitro. Fluoride profiles were determined in plaque generated in vivo on enamel surfaces, which had been previously treated with a 900–ppm fluoride solution. The results showed the previously reported fall from the plaque surface, but in addition, a further rise towards the enamel surface was seen. The data imply that enamel loaded with fluoride can release some of this fluoride back into the plaque and may act as a fluoride reservoir.

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“…Nevertheless, the available information concentrates on interactions of fluoride at relatively high (millimolar) concentrations. Reaction mechanisms at concen trations as low as those of the free motile fluoride ion in plaque (0.05-0.16 ppm) [Agus et al, 1980; Jenkins and Edgar, 1977] are still obscure. This situation is due mainly to difficulties in detecting and quantifying such extremely low concentrations of the ion.…”

mentioning

confidence: 99%

Interactions of Micromolar Concentrations of Fluoride with Streptococcus rattus FA-1

Psarros¹,

Feige²,

Duschner³

1990

Caries Res

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Inhibition of the metabolic activities of bacteria by trace amounts of fluoride is manifested phenomenologically as changes in the pH gradient and/or the electrical potential between the cellular interior and the surrounding medium. These data were obtained from the intracellular/extracellular distribution of radioactively labelled fluoride (¹⁸F), 5,5-dimethyloxazolidine-2,4-dione (¹⁴C), and tetraphenylphosphonium chloride (¹⁴C). When taken up from acidic media, trace concentrations of fluoride (1–100 μM) reduce the intracellular/extracellular pH gradient and affect the electrical potential across the cell membrane. The chromatographic fractionation of fluoride-charged bacterial homogenates showed that fluoride is attached to many proteins of the cytoplasm, the cell membrane, and to nonproteinaceous components of the cell wall. Lysozyme treatment synergistically affects the vulnerability of the bacteria to micromolar concentrations of fluoride.

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Ionized and bound fluoride in resting and fermenting dental plaque and individual human caries experience

Cited by 31 publications

References 17 publications

Diurnal Fluoride Concentration in Whole Saliva in Children Living in a High- and a Low-Fluoride Area

Diurnal Fluoride Concentration in Whole Saliva in Children Living in a High- and a Low-Fluoride Area

Fluoride Profiles in Dental Plaque in vivo Formed on Fluoride Pre–Treated Human Enamel

Interactions of Micromolar Concentrations of Fluoride with Streptococcus rattus FA-1

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