To understand the global response of thermospheric‐ionospheric (TI) parameters to variations in solar irradiance measurements from the Global‐Scale Observations of the Limb and Disk (GOLD) ultraviolet imaging spectrograph, solar radio flux F10.7, predictions from the Coupled Thermosphere Ionosphere Plasmasphere electrodynamics (CTIPe) model, and International Global Navigation Satellite System Service total electron content maps (TEC) have been used. Various parameters such as GOLD O/N2, O2, and the nighttime peak electron density (Nmax) have been compared with the CTIPe model simulations. The GOLD observed Nmax shows a number of significant features including a winter anomaly and an equatorial ionization anomaly. The comparison with solar proxies showed that the GOLD QEUV correlates very well with the EUV observations compared to the F10.7 index. The study also examined the relationship between the solar proxies and Nmax on different time scales and found that Nmax responded significantly to QEUV at both medium‐ and long‐term timescales. Furthermore, a low correlation between Nmax in the equatorial region and solar proxies was found. A delayed ionospheric TEC response against solar flux variations within the 27‐day solar rotation was investigated. This ionospheric delay of TEC with respect to solar flux was observed to be less than 1 day, which was reproduced in model simulations. The current study has shown that the GOLD observations can be used to investigate the delayed ionospheric response and to gain a better understanding of the influence of solar activity on the TI system.