“…Differential mRNA expression of mGlu1 splice variants has been observed in both rodent and human brain (Berthele et al 1998; intense expression of mGlu1α has been found in Purkinje cells, mitral and tufted cells, hippocampal interneurons, thalamic neurons and neurons in the substantia nigra (Martin et al 1992;Baude et al 1993;Fotuhi et al 1993;Ferraguti et al 2004), whereas the mGlu1ÎČ splice variant is strongly expressed in CA3 hippocampal pyramidal neurons, granule cells of the dentate gyrus and lateral hypothalamus (Ferraguti et al 1998;Mateos et al 1998). At the electron-microscopic level, mGlu1 has been mostly detected in postsynaptic neuronal elements in the cerebral cortex (Ong et al 1998), hippocampus (Baude et al 1993;Lujan et al 1996Lujan et al , 1997Hanson and Smith 1999), striatum (Hanson and Smith 1999), thalamus (Martin et al 1992;Godwin et al 1996;Liu et al 1998), hypothalamus (van den Pol et al 1994), cerebellar cortex (Martin et al 1992;Baude et al 1993;Gorcs et al 1993;Nusser et al 1994;Lujan et al 19961997;Jaarsma et al 1998;Mateos et al 2000) and dorsal cochlear nucleus (Petralia et al 1996b;Jaarsma et al 1998).…”