1996
DOI: 10.1002/(sici)1096-9861(19960826)372:3<356::aid-cne3>3.0.co;2-1
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Ionotropic and metabotropic glutamate receptors show unique postsynaptic, presynaptic, and glial localizations in the dorsal cochlear nucleus

Abstract: The dorsal cochlear nucleus (DCN) is a major brain center for integration of auditory information, and excitatory amino acid neurotransmission plays a central role in the processing of this information. In this study, the distribution of glutamate receptors was examined with preembedding immunocytochemistry, using 14 antibodies to ionotropic (GluR1, GluR2/3, GluR4, GluR5-7, GluR6/7, KA2, NR1, NR2A/B, delta 1/2) and metabotropic (mGluR1 alpha, mGluR2/3, mGluR5) glutamate receptor subtypes. Each of these antibod… Show more

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Cited by 141 publications
(61 citation statements)
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“…Although the distribution of mGlu5a and mGlu5b appears largely similar, mGlu5a is found most abundantly in the young rat, whereas mGlu5b predominates in the adult rat (Joly et al 1995;Romano et al 1996). At the electron-microscopic level, mGlu5 has mainly been localized to somatic and dendritic profiles in the hippocampus (Lujan et al 1996(Lujan et al , 1997Hanson and Smith 1999), basal ganglia Hanson andSmith 1999), thalamus (Godwin et al 1996;Liu et al 1998), hypothalamus , cerebellar cortex (Negyessy et al 1997), dorsal cochlear nucleus (Petralia et al 1996b) and dorsal horn of the spinal cord (Vidnyanszky et al 1994;Jia et al 1999). In a few studies, mGlu5 immunoreactivity has been reported not only in somatodendritic domains of neurons, but also in axons or vesiclecontaining profiles (Jia et al 1999) and in astrocytes (van den Pol et al 1995).…”
Section: Distribution Of Group I Mglusmentioning
confidence: 99%
See 1 more Smart Citation
“…Although the distribution of mGlu5a and mGlu5b appears largely similar, mGlu5a is found most abundantly in the young rat, whereas mGlu5b predominates in the adult rat (Joly et al 1995;Romano et al 1996). At the electron-microscopic level, mGlu5 has mainly been localized to somatic and dendritic profiles in the hippocampus (Lujan et al 1996(Lujan et al , 1997Hanson and Smith 1999), basal ganglia Hanson andSmith 1999), thalamus (Godwin et al 1996;Liu et al 1998), hypothalamus , cerebellar cortex (Negyessy et al 1997), dorsal cochlear nucleus (Petralia et al 1996b) and dorsal horn of the spinal cord (Vidnyanszky et al 1994;Jia et al 1999). In a few studies, mGlu5 immunoreactivity has been reported not only in somatodendritic domains of neurons, but also in axons or vesiclecontaining profiles (Jia et al 1999) and in astrocytes (van den Pol et al 1995).…”
Section: Distribution Of Group I Mglusmentioning
confidence: 99%
“…Differential mRNA expression of mGlu1 splice variants has been observed in both rodent and human brain (Berthele et al 1998; intense expression of mGlu1α has been found in Purkinje cells, mitral and tufted cells, hippocampal interneurons, thalamic neurons and neurons in the substantia nigra (Martin et al 1992;Baude et al 1993;Fotuhi et al 1993;Ferraguti et al 2004), whereas the mGlu1ÎČ splice variant is strongly expressed in CA3 hippocampal pyramidal neurons, granule cells of the dentate gyrus and lateral hypothalamus (Ferraguti et al 1998;Mateos et al 1998). At the electron-microscopic level, mGlu1 has been mostly detected in postsynaptic neuronal elements in the cerebral cortex (Ong et al 1998), hippocampus (Baude et al 1993;Lujan et al 1996Lujan et al , 1997Hanson and Smith 1999), striatum (Hanson and Smith 1999), thalamus (Martin et al 1992;Godwin et al 1996;Liu et al 1998), hypothalamus (van den Pol et al 1994), cerebellar cortex (Martin et al 1992;Baude et al 1993;Gorcs et al 1993;Nusser et al 1994;Lujan et al 19961997;Jaarsma et al 1998;Mateos et al 2000) and dorsal cochlear nucleus (Petralia et al 1996b;Jaarsma et al 1998).…”
Section: Distribution Of Group I Mglusmentioning
confidence: 99%
“…Through this synapse CwCs receive indirect AN synaptic stimulation to inhibit FCs (Golding and Oertel, 1997;Davis and Young, 2000). The PSD of the PF on CwC dendritic spines is enriched with the GluR2 and 3 subunits and has low levels of GluR4 (Petralia et al, 1996;Gardner et al, 2001). Therefore, the PF/ CwC synapse permits one to test whether or not neurons that receive indirect input of a main source of excitation also redistribute AMPAR subunits at the synapse in response to the denervation.…”
Section: Redistribution Of Glur2/3 Subunits At the Pf Synapses On Fc mentioning
confidence: 99%
“…Groups II and III mGluRs, on the other hand, are negatively linked to adenylyl cyclase. Although group I mGluRs have been reported in rodent DCN (Molitor and Manis, 1997;Sanes et al, 1998;Bilak and Morest, 1998;Petralia et al, 1996) and superior olivary complex (Kotak and Sanes, 1995;Ene et al, 2003;Kushmerick et al, 2004), little more is known about the abundance and role of these receptors in other nuclei of the auditory brainstem.…”
Section: Introductionmentioning
confidence: 99%