Iontophoresis mediated localized delivery of liposomal gold nanoparticles for photothermal and photodynamic therapy of acne

Alvi, Syed Baseeruddin; Rajalakshmi, P.; Jogdand, Anil; Sanjay, Ambekar Yogeshwari; Veeresh, Bantal; John, Richard R.; Rengan, Aravind Kumar

doi:10.1039/d0bm01712d

Cited by 23 publications

(10 citation statements)

References 33 publications

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“…The alteration in the size and shape of the NPs influenced the light-absorbing property and its efficiency in the production of ROS. It has a wide application as colorimetric sensor, [56] biosensors, catalyst, [57] diagnostics and therapeutics of different diseases such as Colorectal cancer, [58] Breast cancer [59][60] , Cervical cancer, [61] Liver cancer, [62] Lung cancer, [63] acne and skin diseases, [64] eye conditions such as actinic keratosis, [65] psoriasis, [66] arthritis, [67] restenosis, and atherosclerosis. [68] The synthesis method influences the morphology of NPs.…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

Photosensitizer Anchored Nanoparticles: A Potential Material for Photodynamic Therapy

et al. 2022

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Detection and treatment of cancer have been demanding areas with the increase in cancer and malignant diseases across the globe. Photodynamic therapy is a multi‐step treatment procedure using photosensitizers as a drug in the presence of light. Photosensitizers anchored on different nanomaterials through covalent and non‐covalent interactions contribute significantly to photodynamic therapy. Nanoparticles have been employed as promising carriers to transport photosensitizers to the target cells. Photosensitizer functionalized nanoparticles are more effective in terms of stability and water solubility than bare ones. This review is a brief account of different types of nanoparticles functionalized on photosensitizers currently used for photodynamic therapy. We have focused on photosensitizer anchored organic, inorganic, and carbon‐based nanomaterials, which can be effectively used in photodynamic therapy.

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Section: Gold Nanoparticlesmentioning

confidence: 99%

Photosensitizer Anchored Nanoparticles: A Potential Material for Photodynamic Therapy

et al. 2022

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“…To be effective, there are three necessary nontoxic components involved in the PDT process: a specific light source, the light-activated photosensitizer (PS) and molecular oxygen ( Kwiatkowski et al, 2018 ). Briefly, cancer PDT (CPDT) is based on the ability of PS to specifically accumulate in tumor tissue and subsequent stimulate the production of reactive oxygen species (ROS) including singlet oxygen ( 1 O2), hydroxyl radicals (·OH) and superoxide radicals (·O2 − ) under local exposure of irradiation with visible light of specific wavelength ( Alvi et al, 2021 ; Hu et al, 2021 ). The resultant ROS can cause irreversible oxidative damage to tumor cells, induce microvascular injury, stimulate immune responses, and trigger a series of cell death mechanisms ( Juarranz et al, 2008 ; Robertson et al, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Bibliometric Analysis of Global Research on Cancer Photodynamic Therapy: Focus on Nano-Related Research

et al. 2022

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A growing body of research has illuminated that photodynamic therapy (PDT) serves as an important therapeutic strategy in oncology and has become a hot topic in recent years. Although numerous papers related to cancer PDT (CPDT) have been published, no bibliometric studies have been conducted to summarize the research landscape, and highlight the research trends and hotspots in this field. This study collected 5,804 records on CPDT published between 2000 and 2021 from Web of Science Core Collection. Bibliometric analysis and visualization were conducted using VOSviewer, CiteSpace, and one online platform. The annual publication and citation results revealed significant increasing trends over the past 22 years. China and the United States, contributing 56.24% of the total publications, were the main driving force in this field. Chinese Academy of Sciences was the most prolific institution. Photodiagnosis and Photodynamic Therapy and Photochemistry and Photobiology were the most productive and most co-cited journals, respectively. All keywords were categorized into four clusters including studies on nanomaterial technology, clinical applications, mechanism, and photosensitizers. “nanotech-based PDT” and “enhanced PDT” were current research hotspots. In addition to several nano-related topics such as “nanosphere,” “nanoparticle,” “nanomaterial,” “nanoplatform,” “nanomedicine” and “gold nanoparticle,” the following topics including “photothermal therapy,” “metal organic framework,” “checkpoint blockade,” “tumor microenvironment,” “prodrug” also deserve further attention in the near future.

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“…To effectively mediate PTT, nano-scale materials that absorb light across a wide range of the NIR spectrum and exhibit high photothermal conversion efficiency are critical. Suitable nanomaterials developed to date have included gold nanoparticles (NPs) ( Zhang Y. et al, 2019 ; Alvi et al, 2021 ), carbon-based nanomaterials ( Shen et al, 2020 ; Yu et al, 2020 ), and semiconductor nanostructures ( Guo et al, 2017 ; Wang et al, 2019 ; Han et al, 2021 ). Fe 3 O 4 NPs have previously been used selectively as contrast agents in the context of T2 magnetic resonance (MR) imaging, shortening the transverse relaxation time to improve negative contrast in T2-weighted images ( Cheng et al, 2011 ; Cheng et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Fe3O4/PDA Nanocomposites for Osteosarcoma Magnetic Resonance Imaging and Photothermal Therapy

Zhang

Ning

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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Osteosarcomas commonly develop in the metaphysis of the long diaphysis, resulting in pronounced malignancy and high rates of early pulmonary metastasis. At present, osteosarcoma patients exhibit relatively poor survival rates owing these metastases and to the emergence of tumor chemoresistance. As such, there is an urgent need to identify other approaches to treating affected patients. Herein, we synthesized Fe3O4@PDA nanocomposites that exhibited excellent biocompatibility and low toxicity in human and animal model systems. The resultant nanoparticles were able to improve T2 magnetic resonance imaging and to enhance the signal-to-noise ratio associated with osteosarcoma tumors in animal models. Moreover, we were able to successfully leverage these Fe3O4@PDA particles as a photothermal agent capable of significantly inhibiting the growth of tumors and preventing their metastasis to the lung compartment. Together, these results highlight a novel therapeutic platform that has the potential to guide both the more effective diagnosis and treatment of osteosarcoma patients in clinical applications.

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Iontophoresis mediated localized delivery of liposomal gold nanoparticles for photothermal and photodynamic therapy of acne

Abstract: Iontophoresis mediated localized delivery of drug entrapping liposomal gold nanoparticles for photothermal and photodynamic therapy of acne.

Cited by 23 publications

References 33 publications

Photosensitizer Anchored Nanoparticles: A Potential Material for Photodynamic Therapy

Photosensitizer Anchored Nanoparticles: A Potential Material for Photodynamic Therapy

Bibliometric Analysis of Global Research on Cancer Photodynamic Therapy: Focus on Nano-Related Research

Synthesis of Fe3O4/PDA Nanocomposites for Osteosarcoma Magnetic Resonance Imaging and Photothermal Therapy

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