iota-Carrageenan hydrogels for methotrexate delivery

Кочкина, Н. Е.; Никитина, М. А.; Agafonov, Mikhail; Delyagina, Ekaterina; Терехова, И. В.

doi:10.1016/j.molliq.2022.120790

Cited by 7 publications

(14 citation statements)

References 35 publications

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“…The 3D structure formation is due to the aggregation of the macromolecules through electrostatic interactions and hydrogen bonds. Successful loading of methotrexate cyclodextrin inclusion complex into 1% iota carrageenan was presented by Kochkina et al [111]. The cyclodextrin complex did not influence the gel rheology and mechanical stability.…”

Section: Other Physical Hydrogelsmentioning

confidence: 98%

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Gel Formulations for Topical Treatment of Skin Cancer: A Review

Slavkova

Tzankov

Popova

et al. 2023

Gels

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Skin cancer, with all its variations, is the most common type of cancer worldwide. Chemotherapy by topical application is an attractive strategy because of the ease of application and non-invasiveness. At the same time, the delivery of antineoplastic agents through the skin is difficult because of their challenging physicochemical properties (solubility, ionization, molecular weight, melting point) and the barrier function of the stratum corneum. Various approaches have been applied in order to improve drug penetration, retention, and efficacy. This systematic review aims at identifying the most commonly used techniques for topical drug delivery by means of gel-based topical formulations in skin cancer treatment. The excipients used, the preparation approaches, and the methods characterizing gels are discussed in brief. The safety aspects are also highlighted. The combinatorial formulation of nanocarrier-loaded gels is also reviewed from the perspective of improving drug delivery characteristics. Some limitations and drawbacks in the identified strategies are also outlined and considered within the future scope of topical chemotherapy.

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Section: Other Physical Hydrogelsmentioning

confidence: 98%

“…The drug release is also affected by the rheological behavior of the gel [141,175,176]. Most of the performed studies indicate that gels are non-Newtonian systems and possess pseudoplastic rheology [100,111,191]. This indicates that the viscosity in high shear, thus facilitating the gel application.…”

Section: Rheology Studiesmentioning

confidence: 99%

Gel Formulations for Topical Treatment of Skin Cancer: A Review

Slavkova

Tzankov

Popova

et al. 2023

Gels

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“…Kochkina et al realized a ι-CRG-based hydrogel containing Methotrexate (MTX), a strong therapeutic agent for various types of diseases. ι-CRG was dissolved in water and the solution was heated to 45 °C and then cooled at room temperature [ 60 ]. Because of MTX’s poor solubility in water, β -cyclodextrins ( β CDs) were added as additives, displaying solubilizing abilities [ 112 ] and increasing the MTX content in the hydrogel.…”

Section: Natural Hydrogelsmentioning

confidence: 99%

“…MTX and β CDs did not affect ι-CRG’s viscoelastic properties and, thus, the formation of the gel. The obtained release study’s results showed that the ι-CRG-MTX- β CD system is able to reduce MTX’s permeation and to prolong MTX’s transmembrane transport [ 60 ].…”

Section: Natural Hydrogelsmentioning

confidence: 99%

Polysaccharide-Based Hydrogels and Their Application as Drug Delivery Systems in Cancer Treatment: A Review

Dattilo

Patitucci

Prete

et al. 2023

JFB

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Hydrogels are three-dimensional crosslinked structures with physicochemical properties similar to the extracellular matrix (ECM). By changing the hydrogel’s material type, crosslinking, molecular weight, chemical surface, and functionalization, it is possible to mimic the mechanical properties of native tissues. Hydrogels are currently used in the biomedical and pharmaceutical fields for drug delivery systems, wound dressings, tissue engineering, and contact lenses. Lately, research has been focused on hydrogels from natural sources. Polysaccharides have drawn attention in recent years as a promising material for biological applications, due to their biocompatibility, biodegradability, non-toxicity, and excellent mechanical properties. Polysaccharide-based hydrogels can be used as drug delivery systems for the efficient release of various types of cancer therapeutics, enhancing the therapeutic efficacy and minimizing potential side effects. This review summarizes hydrogels’ classification, properties, and synthesis methods. Furthermore, it also covers several important natural polysaccharides (chitosan, alginate, hyaluronic acid, cellulose, and carrageenan) widely used as hydrogels for drug delivery and, in particular, their application in cancer treatment.

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“…Recently, we proposed iCR gels for methotrexate (MTX) delivery [ 20 ]. MTX ( Figure 1 ) is a therapeutic agent having a wide range of applications, including treatment of oncological and autoimmune diseases [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

β-Cyclodextrin Modified Hydrogels of Kappa-Carrageenan for Methotrexate Delivery

Nikitina,

Kochkina,

Arinina

et al. 2023

Pharmaceutics

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This work is aimed at developing a kappa-carrageenan (kCR) gel with increased methotrexate (MTX) content. β-Cyclodextrin (βCD), which is able to inclusion complex formation with MTX, has been used to increase the drug concentration in the hydrogel. The rheological behavior of the designed gels was investigated and the influence of MTX and βCD on the viscoelastic properties of kCR gel was studied in detail. The effect of βCD and its concentration on the MTX-releasing rate from the kCR gels was examined. The properties of kappa- and iota-carrageenans loaded with MTX were compared and the differences observed were explained in terms of different binding affinities of MTX to these polymers. The obtained gels provided desirable viscoelastic properties useful for topical application.

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iota-Carrageenan hydrogels for methotrexate delivery

Cited by 7 publications

References 35 publications

Gel Formulations for Topical Treatment of Skin Cancer: A Review

Gel Formulations for Topical Treatment of Skin Cancer: A Review

Polysaccharide-Based Hydrogels and Their Application as Drug Delivery Systems in Cancer Treatment: A Review

β-Cyclodextrin Modified Hydrogels of Kappa-Carrageenan for Methotrexate Delivery

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