Ioxaglate, a new low osmolar contrast medium used in femoral angiography

Holm, Magnus; Praestholm, J

doi:10.1259/0007-1285-52-615-169

Cited by 35 publications

(9 citation statements)

References 7 publications

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“…Our results demonstrate the better subjective tolerance and lesser hemodynamic side-effects of Hexabrix@ compared to Urografin@. These findings confirm the results of peripheral angiography [13][14][15] during which the difference in discomfort for the patient is even greater [13] because a comparable volume of contrast material is injected into a smaller vascular compartment.…”

Section: Discussionsupporting

confidence: 84%

Hemodynamic changes after angiocardiography with a new low osmolar contrast medium (sodium‐meglumin‐joxaglat)

Baur

1983

Cathet. Cardiovasc. Diagn.

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We evaluated the hemodynamic effects of sodium-meglumin-joxaglat (Hexabrix) compared to sodium-meglumin-diatrizoat (Urografin 76) after left ventriculography in a double-blind randomized study on 24 patients (12 patients per group). Hemodynamic measurements at rest and the extent of ischemic heart disease were comparable in the two groups. Measurements were made at rest and between the second and third minute, between the fifth and sixth minute, and between the eighth and ninth minute following injection of 0.7 ml/kg of contrast medium into the left ventricle. Additionally left ventricular volumes and ejection fraction of the second and fifth beat following the onset of injection were calculated. The discomfort was graded by the patients on a scale of 1-4. After 3 min there was a significant but comparable increase in right atrial, pulmonary artery, and pulmonary capillary wedge pressure (64, 35, and 61%, respectively for the Hexabrix group and 61, 36, and 58% for the Urografin group). Cardiac index and stroke volume index rose significantly higher in the Urografin group and left ventricular work index increased significantly only after injection of Urografin 76. Ejection fraction decreased 11% in the Hexabrix group and 9% in the Urografin group. The grade of discomfort was 1.83 +/- 1 in Hexabrix group and 2.83 +/- 0.8 in the Urografin group (p less than 0.05). Thus, Hexabrix represents an advance in angiocardiography, both from the subjective and objective standpoint.

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Section: Discussionsupporting

confidence: 84%

Hemodynamic changes after angiocardiography with a new low osmolar contrast medium (sodium‐meglumin‐joxaglat)

Baur

1983

Cathet. Cardiovasc. Diagn.

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“…1978, HOLM & PRAESTHOLM 1979, as well as pain and heat sensations (GONSETTE 1978, GRAINGER 1979, HOLM & PRAESTHOLM, TILLMANN et colI. 1979 after intravascular application of a new contrast medium, sodium/meglumine ioxaglate with low hyperosmolality.…”

mentioning

confidence: 99%

Changes in the Rheologic Properties of Blood as Induced by Sodium/Meglumine Ioxaglate Compared with Sodium/Meglumine Diatrizoate and Metrizamide

Stäubli¹,

Braunschweig²,

Tillmann³

1982

Acta Radiologica. Diagnosis

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The influence of the new angiographic contrast medium sodium/meglumine ioxaglate on the rheologic properties of blood in vitro was assessed by measurements of blood viscosity and by observation of red cell shape and aggregation. Compared with iodine-similar concentrations of sodium/meglumine diatrizoate and metrizamide, exposition of blood to the new compound was associated with a lower impairment of blood viscosity, rouleaux formation of red cells and with only minor alterations of red cell shape. These favourable results are due to the low hyperosmolality and to absence of direct influence on the red cell membrane of sodium/meglumine ioxaglate.

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“…ratio 3 compounds such as the non-ionic monomeric iopamidol and iohexol or the ionic dimeric ioxaglate. They produce significantly less pain than the ratio 1.5 media at peripheral angiography (3,6,13,17,22,25,(27)(28)(29)37,38,43) and significantly less hemodynamic changes due to a smaller vasodilatory effect (3,20,22,27,28,35,42).…”

mentioning

confidence: 96%

Addition of Local Anesthetics to Contrast Media

Nilsson¹,

Almén²,

Golman³

et al. 1987

Acta Radiol

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Effects of equiosmolar solutions (osmolality 1.35 mol/kg) of the ratio 1.5 contrast medium metrizoate (250 mg l/ml) containing either the local anesthetic mepivacaine or saline were evaluated on subjective discomfort, aortic blood pressure and heart rate in 17patients referred for aortofemoral angiography due to intermittent claudication. Each patient was injected with 30 ml (15 mils) of each solution in random double-blind order. Each patient was then injected with 45 ml (12 ml/s) of the ratio 3 medium ioxaglate (320mg l/ml, osmolality 0.58 mIlkg). loxaglate caused significantly less total discomfort, pain, heat, vocal reactions, involuntary movements and hemodynamic effects than metrizoate-mepivacaine and metrizoate-saline. The effects of the two metrizoate solutions did not differ significantly. Previous contradictory reports on the effects of anesthetics in contrast media were reviewed with regard to experimental design, different osmolality of the test and control solutions, premedication, and pH dependence of local anesthetics. Ratio 3 media are recommended because they produce a more reliable relief of patient discomfort and fewer hemodynamic changes than the addition of loc'al anesthetics to ratio 1.5 media.

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Ioxaglate, a new low osmolar contrast medium used in femoral angiography

Cited by 35 publications

References 7 publications

Hemodynamic changes after angiocardiography with a new low osmolar contrast medium (sodium‐meglumin‐joxaglat)

Hemodynamic changes after angiocardiography with a new low osmolar contrast medium (sodium‐meglumin‐joxaglat)

Changes in the Rheologic Properties of Blood as Induced by Sodium/Meglumine Ioxaglate Compared with Sodium/Meglumine Diatrizoate and Metrizamide

Addition of Local Anesthetics to Contrast Media

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