IP&amp;C - An editorial comment from the WHO

Ellis, Benjamin

doi:10.3396/ijic.v7i1.001.11

Cited by 6 publications

(9 citation statements)

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“…The isolated bacteria in this study were both gram-positive bacteria (Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Listeria species) and gram-negative bacteria (Klebsiellae species, Proteus mirabilis and Pseudomonas aeruginosa). Our nding was agreed with different studies like in Nigeria by Bolarinwa R A et al [16] and India conducted by Barot T et al [18]. [20], this difference may be due to the difference in sample size, sample taken from only whole blood, the present study on the other hand higher in prevalence of bacterial contamination than other studies done in Zimbabwe 3.1% (n = 6/196) [21], Uganda 3.5% (n = 18 /510) [5].…”

Section: Discussionsupporting

confidence: 93%

“…Considering the drug resistance pattern, the nding s of this study was agreed with a study from Nigeria and they also reported that gram-positive bacteria were sensitive for Gentamicin and Ceftriaxone but the majority of the antibiotics were resistant [16]. The only antibiotic that showed resistant to the Pseudomonas aeruginosa was Gentamicin.…”

Section: Discussionsupporting

confidence: 88%

“…The prevalence of bacterial contamination among those blood products which were collected with non-diverging donor blood collection method was 7.4% (n = 14/188) and almost close to previous studies reported from Africa countries like Ghana by Adjei A A et al 9% (n = 28/303) [8] and Nigeria by Bolarinwa R A et al 8.8%, (n = 14/162) [16]. The bacterial contamination of blood products collected with diverging done in this study is more or less similar to another nding like in Malaysia carried out by Jumaah N et al was 1.7% (n = 12 /702) [17].…”

Section: Discussionsupporting

confidence: 83%

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Prevalence of Bacterial Contamination and Antimicrobial Susceptibility Pattern among Blood and Blood Components collected with and without diverging method at Armed Forces Comprehensive Specialized Hospital, Addis Ababa, Ethiopia

Tsegaye¹

2020

Preprint

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Background: Transfusion of bacterial contaminated blood and blood components could be a cause of morbidity and mortality. Understanding the mechanism of blood contamination is important in developing infection control strategy.Methods: A comparative cross-sectional study was done 376 blood and blood components collected with and without diverging method in Armed Forces Comprehensive Specialized Hospital. Then, Culturing of collected blood and blood components were inoculated in broth then subcultured on agar plate. And then, the drugs sensitivity test was done for each isolate. Bivariate analysis and multivariate logistic regression were used to infer association.Results: The overall prevalence of bacterial contamination among blood and blood components were 17 (4.5%). The prevalence of bacterial contamination of blood and blood components collected with the non-diverging and diverging method was 14 (7.4%) and 3 (1.6 %) respectively with P value of 0.05. Staphylococcus epidermidis were the most dominate isolates. Gram positive isolates showed more than 74% sensitive for antibiotics and also became more than 9% resistant. Most gram negative isolates became sensitive but Pseudomonas aeruginosa showed resistant for Gentamicin. 29.4% (n= 5/17) isolated bacteria were multidrug resistant.Conclusion: There was a difference between bacterial contamination in blood and blood components collected between diverging and non-diverging blood collection methods.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 83%

See 1 more Smart Citation

Prevalence of Bacterial Contamination and Antimicrobial Susceptibility Pattern among Blood and Blood Components collected with and without diverging method at Armed Forces Comprehensive Specialized Hospital, Addis Ababa, Ethiopia

Tsegaye¹

2020

Preprint

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“…Compared to what has been reported from other African countries [9][10][11][12],the average unconfirmed South African AP contamination rate of 2Á7% is comparable to the prevalence data from Uganda, below the rates published in Ghana [11] and Zimbabwe [12] and 10-fold higher than the rate quoted for the high-income countries [5,6].…”

Section: Discussioncontrasting

confidence: 43%

“…Published data on bacterial contamination are scarce for the African continent where transfusion medicine practice in most countries is in early development or poorly implemented. Small studies assessing the prevalence of bacterial contamination in platelets have been conducted in Uganda, Zimbabwe, Ghana and Nigeria, and these studies indicate that the rates of bacterial contamination are substantially higher compared to those of high-income countries ranging between 2Á1% and 10Á3% [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Bacterial surveillance of apheresis platelets in South Africa (January 2011 to December 2016)

Jentsch

Swanevelder

2018

ISBT Science Series

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Background Globally, bacterial contamination of platelets remains the major transfusion‐related infectious risk. Limited data are available from low‐middle income countries. The South African National Blood Service routinely tests a percentage of apheresis platelets for bacterial contamination. We report on contamination rates from January 2011 to December 2016. Methods A retrospective analysis of the surveillance data from apheresis platelets was performed. Two to 4 ml of each apheresis product was collected aseptically and divided equally into an aerobic and anaerobic culture bottle using the BacT/ALERT (bioMerieux) or BACTEC™ (Beckton Dickinson) systems. Bacterial identification was done using the MicroScan (Beckman Coulter) system. Results A total of 87 841 apheresis platelets were collected between 2011 and 2016 of which 18% were tested. The average positive culture rate was 2·7%, ranging between 0·6% (2011) and 5·22% (2015). Gram‐positive bacteria constituted 94% of all isolates (269/285), ten (4%) gram‐negative bacteria and 6 (2%) fungi were detected. The most common bacterial isolates were Cutibacterium acnes (35%), coagulase‐negative Staphylococci (26%), Bacillus spp. (8%), Corynebacteria spp. (8%). A total of nine highly pathogenic bacteria were isolated: two Acinetobacter spp, one each of Enterobacter spp., Serratia spp., Klebsiella spp., one Staphylococcus aureus and three Listeria spp. Average time to positivity for bacteria was 5·9 days. No cases of sepsis or death were reported during this time. Conclusion Bacterial contamination rates, mostly due to gram‐positive bacteria, increased since 2011. Bacterial screening must be aligned with international recommendations, and novel technologies should be explored to reduce the residual risk.

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Skin flora and bacterial contamination of diversion pouch and recovered platelet components in Moroccan blood donors

Mehdaoui

Benajiba²,

Boulahdid³

et al. 2020

Transfusion Medicine

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Objective: The objective of this study was to evaluate bacterial reduction procedures used during whole-blood donations in Morocco. Background: Bacterial contamination still poses serious challenges to blood safety, especially in countries with limited resources. Methods: In the first part of this study, we analysed 233 swab samples taken from blood donors' antecubital fossa. After donation, a second batch of samples was analysed from the diversion pouches of corresponding donors. In addition, we searched for the prevalence of bacterial contamination in 568 randomly chosen platelet components at their expiration date in order to control for the entire blood unit preparation process. Results: The most frequently found bacterial species at the antecubital fossa of healthy blood donors were coagulase-negative Staphylococcus, aerophilic Corynebacterium, Staphylococcus aureus, Bacillus sp. and Micrococcus sp. After donation, 5.15% of the diversion pouches were contaminated with bacterial species, the most notable being Bacillus sp., aerophilic Corynebacterium, coagulase-negative Staphylococcus, Staphylococcus aureus and Pseudomonas aeruginosa. Of 568 platelet components, 18 were contaminated with three bacterial species: Bacillus sp., coagulase-negative Staphylococcus and Staphylococcus aureus. Conclusion: All three bacterial species found in platelet components were detected on the skin of blood donors. Serious measures need to be taken and enforced to ensure blood safety.

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IP&C - An editorial comment from the WHO

Cited by 6 publications

References 0 publications

Prevalence of Bacterial Contamination and Antimicrobial Susceptibility Pattern among Blood and Blood Components collected with and without diverging method at Armed Forces Comprehensive Specialized Hospital, Addis Ababa, Ethiopia

Prevalence of Bacterial Contamination and Antimicrobial Susceptibility Pattern among Blood and Blood Components collected with and without diverging method at Armed Forces Comprehensive Specialized Hospital, Addis Ababa, Ethiopia

Bacterial surveillance of apheresis platelets in South Africa (January 2011 to December 2016)

Skin flora and bacterial contamination of diversion pouch and recovered platelet components in Moroccan blood donors

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