Bio-inspiration focuses on translating the evolutionary successes of natural species into engineering systems that mimic the geometry, function, and performance of the natural system. In this paper we present a latest comprehensive review of ionic polymer metal composite (IPMC) biomedical and biomimetic applications. IPMC is becoming an increasingly popular material among scholars, engineers and scientists due to its inherent properties of low activation voltage, large bending strain, flexibility, softness, suitable response time which make them a strong candidate to be applied as artificial muscle in biomimetic land and underwater applications. Among the diversity of electro active polymers (EAPs), recently developed IPMCs are good candidates for use in bio-related application because of their biocompatibility. Several recently reported IPMC biomimetic applications have been reported in this paper. The applications of IPMC have been growing due to progression in its manufacturing techniques, development of more accurate response models and control techniques, and recently more sophisticated IPMC actuator applications have been performed. This indicates that the IPMC actuators hold potential for more sophisticated and controlled applications in fields of biomedical and biomimetic. Extensive references are provided for more indepth explanation.