Ipsilateral Zoster Ophthalmicus Post COVID-19 Vaccine in Healthy Young Adults

Abstract

Thimmanagari et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Potential risk factors for Varicella‐zoster virus reactivation after COVID‐19 vaccination

“…We analyzed 93 cases of VZV reactivation following the COVID‐19 vaccine reported in literature. 1 , 2 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 We decided to focus only on cases with enough information to allow for a correct risk assessment, for example, we did not include all the reports where age or sex were not present. There was no significant difference between males and females (44 men vs 49 women), and, in accordance with the previous observations, 3 the majority of the VZV reactivations were secondary to mRNA vaccines (46 following Pfizer's BNT162b2 and 19 following Moderna's mRNA‐1273 vs 18 following Astrazeneca's AZD1222 (ChAdOx1), 2 following Johnson & Johnson's JNJ‐78436735 (Ad26.COV2.S), 1 following Bharat Biotech's BBV152 (Covaxin), 1 following Sinopharm's BBIBP‐CorV vaccine (Vero Cells), and 1 following Sputnik V (Gam‐COVID‐Vac); 5 not specified).…”

Neuro-Ophthalmological Complications of the COVID-19 Vaccines: A Systematic Review

“…A total of 14 case reports and 2 case series have been selected for inclusion in the final report. Overall, 76 cases of post-COVID-vaccination adverse events have been reported, including ON (n = 61) (22–25), optic disc edema as atypical presentation of Guillain–Barre syndrome (n = 1 (26), arteritic anterior ischemic optic neuropathy (AAION; n = 1) (27), abducens nerve palsy (n = 1) (28), oculomotor nerve palsy (n = 1) (29), Tolosa–Hunt syndrome (n = 1) (30), herpes zoster ophtalmicus (n = 2) (31), uveitis (n = 3) (32–34), acute macular neuroretinopathy (n = 2) (35), central serous retinopathy (n = 1) (36), acute zonal occult outer retinopathy (AZOOR; n = 1) (27), and bilateral choroiditis (n = 1) (37).…”

“…Two cases of postvaccination herpes zoster ophthalmicus have been described by Thimmanagari et al In one case, a 42-year-old man developed characteristic skin lesions associated with restricted ocular movements and reduced visual acuity one week postvaccination; in the second case, a 49-year-old man developed erythematous papules and vesicles on the right side of the forehead (i.e., V1 dermatome) and edema of the right upper eyelid, without signs of extraocular or optic nerve involvement. Both patients were treated with systemic antiviral medications with a good clinical outcome (31).…”

A Case Report of Herpes Zoster Ophthalmicus and Meningitis After COVID-19 Vaccination

“… 7 Several triggering factors that are associated with this down-regulation of the immune response are advanced age, stress, physical trauma, malignancy, HIV infection, and immunosuppressive drugs. 8 Of particular interest, viral replication appears more frequently in older individuals because of their diminished cell-mediated immunity, a phenomenon known as immunosenescence. 9 Our patient was of older age suffering from diabetes mellitus and hemiplegia.…”