Ipsilesional Motor Cortex Activation with High-force Unimanual Handgrip Contractions of the Less-affected Limb in Participants with Stroke

Andrushko, Justin W.; Gould, Layla; Renshaw, Doug; Forrester, Shannon; Kelly, Michael; Linassi, Gary; Mickleborough, Marla; Oates, Alison; Hunter, Gary; Borowsky, Ron; Farthing, Jonathan P.

doi:10.1016/j.neuroscience.2021.12.011

Cited by 3 publications

(1 citation statement)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Motor dysfunction is the most common symptom of stroke disability. 1,2 Rehabilitation has been proven to improve the degree of disability, and brain plasticity mechanisms theoretically underlie its effectiveness. 3 Corticospinal tract (CST) is the principal motor pathway and exploring its plasticity mechanisms will be useful for the formulation of rehabilitation strategies.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Structural Plasticity Mechanism of Corticospinal Tract during Stroke Rehabilitation Based Automated Fiber Quantification Tractography

Zhang,

Zhao,

Fan

et al. 2024

Neurorehabil Neural Repair

View full text Add to dashboard Cite

Background Corticospinal tract (CST) is the principal motor pathway; we aim to explore the structural plasticity mechanism in CST during stroke rehabilitation. Methods A total of 25 patients underwent diffusion tensor imaging before rehabilitation (T1), 1-month post-rehabilitation (T2), 2 months post-rehabilitation (T3), and 1-year post-discharge (T4). The CST was segmented, and fractional anisotropy (FA), axial diffusion (AD), mean diffusivity (MD), and radial diffusivity (RD) were determined using automated fiber quantification tractography. Baseline level of laterality index (LI) and motor function for correlation analysis. Results The FA values of all segments in the ipsilesional CST (IL-CST) were lower compared with normal CST. Repeated measures analysis of variance showed time-related effects on FA, AD, and MD of the IL-CST, and there were similar dynamic trends in these 3 parameters. At T1, FA, AD, and MD values of the mid-upper segments of IL-CST (around the core lesions) were the lowest; at T2 and T3, values for the mid-lower segments were lower than those at T1, while the values for the mid-upper segments gradually increased; at T4, the values for almost entire IL-CST were higher than before. The highest LI was observed at T2, with a predominance in contralesional CST. The LIs for the FA and AD at T1 were positively correlated with the change rate of motor function. Conclusions IL-CST showed aggravation followed by improvement from around the lesion to the distal end. Balance of interhemispheric CST may be closely related to motor function, and LIs for FA and AD may have predictive value for mild-to-moderate stroke rehabilitation. Clinical Trial Registration. URL: http://www.chictr.org.cn ; Unique Identifier: ChiCTR1800019474.

show abstract

Section: Introductionmentioning

confidence: 99%