Iridium(III)‐Doped Core‐Shell Silica Nanoparticles: Near‐IR Electrogenerated Chemiluminescence in Water

Kesarkar, Sagar; Rampazzo, Enrico; Valenti, G.; Marcaccio, Massimo; Bossi, Alberto; Prodi, Luca; Paolucci, Francesco

doi:10.1002/celc.201700071

Cited by 15 publications

(6 citation statements)

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“…The dye inclusion for every sample of Ru@NPs was estimated by UV−visible spectra, by measuring the concentration of Ru(bpy)(L)BPS complex present in the dispersion, then dividing it by the concentration of NPs, determined as previously reported. 32 The absorption and emission spectra reported in Figure 2 show that the shape and position of the peaks of the Ru(bpy)(L)BPS@NPs samples are very similar to each other, as well as for Ru(bpy)(L)BPS in DMSO solution (orange line). This is attributed to similar environments and ground-state conditions that do not modify the absorption properties, revealing an average from 3 to 21 ruthenium complexes per NP, with the maximum at 2.4% doping level.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Neutral Dye-Doped Silica Nanoparticles for Electrogenerated Chemiluminescence Signal Amplification

et al. 2019

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Immunoassay is probably the primary in vitro technique employed in medical diagnostics. Its different setups include often the well-known and sensitive analytical method based on electrochemiluminescence (ECL), and approaches relying on nanotechnology have the potentiality to further enhance ECL signal response and detection capability. With this intent, we studied the ECL behavior of dye-doped silica–poly(ethylene glycol) core–shell nanoparticles (DDSNPs) doped with neutral Ru(II) complexes in a very large doping range. We found that nanoparticles maintain comparable morphology and dimensions as the amount of Ru(II) neutral complexes that are covalently linked to their silica matrix increases; meanwhile, ECL shows an enhanced response. The 9-fold ECL signal amplification obtained when compared with [Ru(bpy)3]2+-doped silica nanoparticles is due to the synergy between the behavior of neutral Ru(II) complex and the DDSNP architecture: these results pave the way for the development of more efficient probes in ECL technology.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Neutral Dye-Doped Silica Nanoparticles for Electrogenerated Chemiluminescence Signal Amplification

et al. 2019

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“…was obtained with an onset potential of −1.635 V, which was close to the reduction of (bt) 2 Irbza with an onset potential of −1.624 V in Figure A (black line). Based on previous reports of iridium(III) complexes/BPO systems, , the ECL mechanism of (bt) 2 Irbza/BPO is as follows Further, oxidative–reductive ECL of 0.1 mM (bt) 2 Irbza was explored with an optimized concentration (20 mM) of TPrA (Figure S8). As revealed in Figure D (black line), an irreversible oxidation peak of TPrA was observed, and the redox peaks of (bt) 2 Irbza were not obvious in this system.…”

Section: Resultsmentioning

confidence: 99%

“…was obtained with an onset potential of −1.635 V, which was close to the reduction of (bt) 2 Irbza with an onset potential of −1.624 V in Figure 1A (black line). Based on previous reports of iridium(III) complexes/BPO systems, 37,38 the ECL mechanism of (bt) 2 Irbza/BPO is as follows…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Ultrasensitive Nucleic Acid Assay Based on Cyclometalated Iridium(III) Complex with High Electrochemiluminescence Efficiency

et al. 2020

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This work developed a sensitive electrochemiluminescence (ECL) biosensor based on a cyclometalated iridium(III) complex ((bt)2Irbza), which was synthesized for the first time. Annihilation, reductive–oxidative, and oxidative–reductive ECL behaviors of (bt)2Irbza were investigated, respectively. The oxidative–reductive ECL intensity was the strongest compared with the other two, which showed 16.7 times relative ECL efficiency compared with commercial [Ru(bpy)3]2+ under the same experimental conditions. Therefore, an ECL biosensing system with (bt)2Irbza as the anodic luminophore was established for miRNA detection based on a closed bipolar electrode (BPE). Combined with both steric hindrance and catalytic effects induced by hemin/G-quadruplex in the cathodic reservoir of BPE that changed the Faraday current of the cathode and thus mediated the ECL intensity of (bt)2Irbza in the anode of BPE, the ECL sensor stated an ultrahigh sensitivity for microRNA (miRNA-122) analysis with a detection limit of 82 aM.

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“… BPO co‐reactant ECL mechanism where M represents a metal complex . Alternative pathways have also been described …”

Section: Introductionmentioning

confidence: 99%

Co‐Reactant and Annihilation Electrogenerated Chemiluminescence of [Ir(df‐ppy)₂(ptb)]⁺ Derivatives

et al. 2020

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The [Ir(df-ppy) 2 (ptb)] + complex (where df-ppy = 2-(2,4-difluorophenyl)pyridine anion; ptb = 1-benzyl-1,2,3-triazol-4-ylpyridine) has previously been shown to be a promising blue luminophore for electrogenerated chemiluminescence (ECL). Herein, we examine the ECL of three [Ir(df-ppy) 2 (ptb)] + derivatives (containing df(CF 3 )-ppy-Me, df(CN)-ppy, or df-ppy-CF 3 ligands) in comparison with the parent complex. In the annihilation mode, all four complexes exhibited ECL, although the emission from [Ir (df(CN)-ppy) 2 (ptb)] + was weak and red-shifted from its photoluminescence. The absence of this shift in the corresponding reductive-oxidation co-reactant ECL with benzoyl peroxide (BPO), and the very low ECL intensity in oxidative-reductive coreactant ECL with tri-n-propylamine (TPrA) enables this effect to be ascribed to oxidative degradation. The [Ir(df-ppy-CF 3 ) 2 (ptb)] + complex gave the greatest ECL intensities of the four [Ir ðC^NÞ 2 (ptb)] + complexes in the annihilation mode and through both co-reactant pathways, and shows great potential as a blue electrochemiluminophore. In "mixed annihilation" ECL experiments involving the oxidation of Ir(ppy) 3 and the reduction of the [IrðC^NÞ 2 (ptb)] + complexes, only [Ir(df-ppy) 2 (ptb)] + and [Ir (df(CF 3 )-ppy-Me) 2 (ptb)] + elicited the green ECL from Ir(ppy) 3 *, as the electron-withdrawing substituents on the other two complexes lower the SOMO energy of the reduced complexes below that required to attain the Ir(ppy) 3 * excited state upon reaction with [Ir(ppy) 3 ] + . Scheme 1. TPrA co-reactant ECL mechanism in which both the metal complex (M) and co-reactant are electrochemically oxidized. [4a] Alternative pathways, including one in which only the co-reactant is oxidized, [4b] have also been identified. The feasibility of these pathways for any metal complex electrochemiluminophore can be predicted from the reduction potentials and emission energy of the complex. [4c] ChemElectroChem Articles

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Iridium(III)‐Doped Core‐Shell Silica Nanoparticles: Near‐IR Electrogenerated Chemiluminescence in Water

Cited by 15 publications

References 50 publications

Neutral Dye-Doped Silica Nanoparticles for Electrogenerated Chemiluminescence Signal Amplification

Neutral Dye-Doped Silica Nanoparticles for Electrogenerated Chemiluminescence Signal Amplification

Ultrasensitive Nucleic Acid Assay Based on Cyclometalated Iridium(III) Complex with High Electrochemiluminescence Efficiency

Co‐Reactant and Annihilation Electrogenerated Chemiluminescence of [Ir(df‐ppy)₂(ptb)]⁺ Derivatives

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Iridium(III)‐Doped Core‐Shell Silica Nanoparticles: Near‐IR Electrogenerated Chemiluminescence in Water

Cited by 15 publications

References 50 publications

Neutral Dye-Doped Silica Nanoparticles for Electrogenerated Chemiluminescence Signal Amplification

Neutral Dye-Doped Silica Nanoparticles for Electrogenerated Chemiluminescence Signal Amplification

Ultrasensitive Nucleic Acid Assay Based on Cyclometalated Iridium(III) Complex with High Electrochemiluminescence Efficiency

Co‐Reactant and Annihilation Electrogenerated Chemiluminescence of [Ir(df‐ppy)2(ptb)]+ Derivatives

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Co‐Reactant and Annihilation Electrogenerated Chemiluminescence of [Ir(df‐ppy)₂(ptb)]⁺ Derivatives