Iridoid Glycosides from Roots of Verbascum laxum

Alaniya, M. D.; Sutiashvili, M. G.; Shalashvili, K. G.; Skhirtladze, A. V.; Mshvildadze, Vakhtang; Pichette, André

doi:10.1007/s10600-014-1096-4

Cited by 3 publications

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“…Such a structure is formed by acid hydrolysis to produce d-glucose and d-galactose; alkali hydrolysis then produces trans-p-methoxycinnamic acid and a slightly polar glycoside. Spectral analysis data shows that the structure of 6 -O-[6-O-(4"-trans-p-methoxycinnamoyl)-5-hydroxyaucubigenin-(1→1 )-O-β-d-galactopyranosyl]-6""-O-trans-p-methoxycinnamoylaucubin uses glucose as a bridge to link the rare iridoid dimers [49]. Their structures are presented in Figure 4.…”

Section: Bis-iridoidsmentioning

confidence: 99%

Iridoids: Research Advances in Their Phytochemistry, Biological Activities, and Pharmacokinetics

et al. 2020

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Iridoids are a class of active compounds that widely exist in the plant kingdom. In recent years, with advances in phytochemical research, many compounds with novel structure and outstanding activity have been identified. Iridoid compounds have been confirmed to mainly exist as the prototype and aglycone and Ι and II metabolites, by biological transformation. These metabolites have been shown to have neuroprotective, hepatoprotective, anti-inflammatory, antitumor, hypoglycemic, and hypolipidemic activities. This review summarizes the new structures and activities of iridoids identified locally and globally, and explains their pharmacokinetics from the aspects of absorption, distribution, metabolism, and excretion according to the differences in their structures, thus providing a theoretical basis for further rational development and utilization of iridoids and their metabolites.

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