Irinotecan and berberine co-delivery liposomes showed improved efficacy and reduced intestinal toxicity compared with Onivyde for pancreatic cancer

Xue, Wei; Liu, Ying; Xu, Wanjia; Jia, Lirui; Chi, Dongxu; Yu, Jiang; Wang, Jiamei; Zhang, He; Liu, Xiaohong; Wang, Yongjun

doi:10.1007/s13346-020-00884-4

Cited by 24 publications

(10 citation statements)

References 29 publications

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“…41 Furthermore, liposomes delivering both berberine and irinotecan were more effective and exhibited lower intestinal toxicity in the treatment of pancreatic cancer than liposomes delivering either component alone. 42 All of the above studies support our network pharmacological prediction and prove the feasibility of network pharmacological methods in the study of the mechanism of action of TCM.…”

Section: Discussionsupporting

confidence: 72%

Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment

Wang¹,

Miao²,

Kong³

et al. 2021

DDDT

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Background and Aim: Pancreatic cancer is one of the most malignant tumors worldwide. Zuojin pills (ZJP), a traditional Chinese medicine (TCM) formula, which can treat a variety of cancers. However, the active compounds present in ZJP and the potential mechanisms through which ZJP acts against pancreatic cancer have not been thoroughly investigated. Methods: Data on pancreatic cancer-related genes, bioactive compounds, and potential targets of ZJP were downloaded from public databases. Bioinformatics analysis, including protein-protein interaction (PPI), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses, was conducted to identify important components, potential targets, and signaling pathways through which ZJP affects pancreatic cancer. The results of this analysis were verified by in vitro experiments. Results: The network pharmacology analysis results showed that 41 compounds and 130 putative target genes of ZJP were associated with anti-pancreatic cancer effects. ZJP may exert its inhibitory effects against pancreatic cancer by acting on key targets such as JUN, TP53, and MAPK1. Moreover, KEGG analysis indicated that the anti-pancreatic cancer effect of ZJP was mediated by multiple pathways, such as the PI3K-AKT, IL-17, TNF, HIF-1, and P53 signaling pathways. Among these, the PI3K-AKT signaling pathway, which included the highest number of enriched genes, may play a more important role in treating pancreatic cancer. The in vitro results showed that ZJP significantly inhibits the cell cycle and cell proliferation through the PI3K/AKT/caspase pathway and that it can induce apoptosis of pancreatic cancer cells, consistent with the results predicted by network pharmacological methods. Conclusion:This study preliminarily investigated the pharmacological effects of ZJP, which appear to be mediated by multiple compounds, targets and pathways, and its potential therapeutic effect on pancreatic cancer. Importantly, our work provides a promising approach for the identification of compounds in TCM and the characterization of therapeutic mechanisms.

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Section: Discussionsupporting

confidence: 72%

Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment

Wang¹,

Miao²,

Kong³

et al. 2021

DDDT

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“…Many natural active ingredients, such as berberine (BER) (Coelho et al., 2017 ; Wu et al., 2019b ), EGCG (Cheng et al., 2016 ), honokiol (Huang et al., 2017 ; Pillai et al., 2017 ; Huang et al., 2020 ), RES (Gu et al., 2018 ), glycyrrhizin (GL) ( Figure 1 ) (Lv et al., 2020 ), Que (Chen et al., 2019 ) and Sch B (Thandavarayan et al., 2015 ; Cai et al., 2020 ), could reduce DOX-induced cardiotoxicity. In addition, BER (Wang et al., 2021 ) could reduce irinotecan-induced gastrointestinal toxicity. RES could reduce PTX-induced neuropathic pain (Li et al., 2019c ).…”

Section: The Effect Of Natural Active Ingredients Combined With Chemo...mentioning

confidence: 99%

Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review

Shao

et al. 2022

Drug Delivery

124

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Chemotherapy drugs have been used for a long time in the treatment of cancer, but serious side effects are caused by the inability of the drug to be solely delivered to the tumor when treating cancer with chemotherapy. Natural products have attracted more and more attention due to the antitumor effect in multiple ways, abundant resources and less side effects. Therefore, the combination of natural active ingredients and chemotherapy drugs may be an effective antitumor strategy, which can inhibit the growth of tumor and multidrug resistance, reduce side effects of chemotherapy drugs. Nano-drug co-delivery system (NDCDS) can play an important role in the combination of natural active ingredients and chemotherapy drugs. This review provides a comprehensive summary of the research status and application prospect of nano-delivery strategies for the combination of natural active ingredients and chemotherapy drugs, aiming to provide a basis for the development of anti-tumor drugs.

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“…photothermal therapy) and immuno-chemotherapy. 4,6,9,10 Furthermore, liposomes can be functionalized with various molecules such as cholesterol, polyethylene glycol and many different ligands to (1) improve the membrane permeability and drug release, (2) prolong the circulation time by evading the immune system, (3) enhance biosafety, biocompatibility and biodegradability and (4) allow targeted delivery to specific cells types. 9–13…”

Section: Introductionmentioning

confidence: 99%

“…17 Due to the abnormality of blood vessels in tumors with leaking gaps, the nano-sized particles easily penetrate into the cancer cells. 10 However, during the synthesis process, liposome particles are of various sizes, many of which are large. Therefore, extrusion is a simple and effective technique to prepare liposomes with relatively homogeneous nano-size distribution, thereby enhancing the effectiveness of liposomes as a drug delivery system in cancer treatments.…”

Section: Introductionmentioning

confidence: 99%

“…4,6,9,10 Furthermore, liposomes can be functionalized with various molecules such as cholesterol, polyethylene glycol and many different ligands to (1) improve the membrane permeability and drug release, (2) prolong the circulation time by evading the immune system, (3) enhance biosafety, biocompatibility and biodegradability and (4) allow targeted delivery to specific cells types. [9][10][11][12][13] Generally, liposome preparation methods involve lipid(s) dispersion in aqueous media to form the initial liposomes, followed by homogenization (sonication, microemulsification, extrusion) to achieve the desirable particle size and purification (dialysis, chromatographic separation, centrifugation) for analysis. 14 For the initial liposome formation phase, thin-film hydration is highly cost-effective and simple by dissolving and drying the phospholipid and other components in an organic solvent using rotary evaporation to form a thin layer, which is then hydrated to form liposomes.…”

Section: Introductionmentioning

confidence: 99%

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A low-cost, flexible extruder for liposomes synthesis and application for Murrayafoline A delivery for cancer treatment

et al. 2022

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Liposomal encapsulation is a drug delivery strategy with many advantages, such as improved bioavailability, ability to carry large drug loads, as well as controllability and specificity towards various targeted diseased tissues. Currently, most preparation techniques require an additional extrusion or filtering step to obtain monodisperse liposomes with the size of less than 100 nm. In this study, a compact liposome extruder was designed at a cost of $4.00 and used to synthesize liposome suspensions with defined particle size and high homogeneity for Murrayafoline A (Mu-A) loading and release. The synthesized MuA-loaded liposomes displayed a biphasic drug release and remained stable under the storage condition of 4°C. They also significantly reduced the viability of HepG2 cells in the cancer spheroids by 25%. The low-cost, flexible liposome extruder would allow the researchers to study liposomes and their applications in a cost-effective manner.

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Irinotecan and berberine co-delivery liposomes showed improved efficacy and reduced intestinal toxicity compared with Onivyde for pancreatic cancer

Cited by 24 publications

References 29 publications

Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment

Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment

Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review

A low-cost, flexible extruder for liposomes synthesis and application for Murrayafoline A delivery for cancer treatment

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