Irinotecan (CPT11) Plus High-dose 5-Fluorouracil (5-FU) and Leucovorin (LV) as Salvage Therapy for Metastatic Colorectal Cancer (MCRC) after Failed Oxaliplatin Plus 5-FU and LV: a Pilot Study in Taiwan

Tai, Ching Tai; Liu, Jin Hwang; Chen, Wei Shon; Lin, Jen Kou; Wang, Wei Shu; Yen, Chueh Chuan; Chiou, Tzeon Jye; Chen, Po Min

doi:10.1093/jjco/hyg023

Cited by 7 publications

(2 citation statements)

References 19 publications

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“…5-FU, which is one of the most effective chemotherapeutic agents for colorectal adenocarcinoma [28], can produce response rates of ∼11% when used as a single agent [28]. For example, folinic acid [28], leucovorin (LV) [29–31], oxaliplatin (L-OHP), LV in the FOLFOX regimen [32], and irinotecan (CPT-11) and LV in the FOLFIRI regimen [33] are combination therapies for colorectal cancer patients.…”

Section: Combined Treatment Of α-Mangostin With Anticancer Drugsmentioning

confidence: 99%

Anti-Cancer Effects of Xanthones from Pericarps of Mangosteen

Akao¹,

Nakagawa²,

Nozawa³

2008

IJMS

248

188

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Mangosteen, Garcinia mangostana Linn, is a tree found in South East Asia, and its pericarps have been used as traditional medicine. Phytochemical studies have shown that they contain a variety of secondary metabolites, such as oxygenated and prenylated xanthones. Recent studies revealed that these xanthones exhibited a variety of biological activities containing anti-inflammatory, anti-bacterial, and anti-cancer effects. We previously investigated the anti-proliferative effects of four prenylated xanthones from the pericarps; α-mangostin, β-mangostin, γ-mangostin, and methoxy-β-mangostin in various human cancer cells. These xanthones are different in the number of hydroxyl and methoxy groups. Except for methoxy-β-mangostin, the other three xanthones strongly inhibited cell growth at low concentrations from 5 to 20 μM in human colon cancer DLD-1 cells. Our recent study focused on the mechanism of α-mangostin-induced growth inhibition in DLD-1 cells. It was shown that the anti-proliferative effects of the xanthones were associated with cell-cycle arrest by affecting the expression of cyclins, cdc2, and p27; G1 arrest by α-mangostin and β-mangostin, and S arrest by γ-mangostin. α-Mangostin found to induce apoptosis through the activation of intrinsic pathway following the down-regulation of signaling cascades involving MAP kinases and the serine/threonine kinase Akt. Synergistic effects by the combined treatment of α-mangostin and anti-cancer drug 5-FU was to be noted. α-Mangostin was found to have a cancer preventive effect in rat carcinogenesis bioassay and the extract from pericarps, which contains mainly α-mangostin and γ-mangostin, exhibited an enhancement of NK cell activity in a mouse model. These findings could provide a relevant basis for the development of xanthones as an agent for cancer prevention and the combination therapy with anti-cancer drugs.

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Section: Combined Treatment Of α-Mangostin With Anticancer Drugsmentioning

confidence: 99%

Anti-Cancer Effects of Xanthones from Pericarps of Mangosteen

Akao¹,

Nakagawa²,

Nozawa³

2008

IJMS

248

188

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“…Nucleotide analogues, the derivatives of the natural nucleotides found as building blocks of DNA and RNA, are effective in the clinical treatment of human cancers or viral diseases. Flurouracil (5-FU) is one of the most effective chemotherapeutic agents for colorectal adenocarcinoma (Tai et al 2003). Among its derivatives, one derivative, 5-fluoro-2 0 -deoxyuridine 5 0 -phosphate, inhibits thymidylate synthase, resulting in the inhibition of thymidine nucleotide synthesis (Gmeiner 2005).…”

Section: Glucosylation Of Cmpmentioning

confidence: 99%

Cloning and expression of the sucrose phosphorylase gene from Leuconostoc mesenteroides in Escherichia coli

et al. 2007

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The gene encoding sucrose phosphorylase (742sp) in Leuconostoc mesenteroides NRRL B-742 was cloned and expressed in Escherichia coli. The nucleotide sequence of the transformed 742sp comprised an ORF of 1,458 bp giving a protein with calculated molecular mass of 55.3 kDa. 742SPase contains a C-terminal amino acid sequence that is significantly different from those of other Leu. mesenteroides SPases. The purified 742SPase had a specific activity of 1.8 U/mg with a K (m) of 3 mM with sucrose as a substrate; optimum activity was at 37 degrees C and pH 6.7. The purified 742SPase transferred the glucosyl moiety of sucrose to cytosine monophosphate (CMP).

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Characterized mechanism of α-mangostin-induced cell death: Caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells

Nakagawa¹,

Iinuma

Naoe

et al. 2007

Bioorganic & Medicinal Chemistry

160

139

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Irinotecan (CPT11) Plus High-dose 5-Fluorouracil (5-FU) and Leucovorin (LV) as Salvage Therapy for Metastatic Colorectal Cancer (MCRC) after Failed Oxaliplatin Plus 5-FU and LV: a Pilot Study in Taiwan

Abstract: The results of treatment for patients after oxaliplatin failure are encouraging and this treatment protocol is also well tolerated by previously heavily treated patients.

Cited by 7 publications

References 19 publications

Anti-Cancer Effects of Xanthones from Pericarps of Mangosteen

Anti-Cancer Effects of Xanthones from Pericarps of Mangosteen

Cloning and expression of the sucrose phosphorylase gene from Leuconostoc mesenteroides in Escherichia coli

Characterized mechanism of α-mangostin-induced cell death: Caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells

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