Irisin in Coronary Bypass Surgery

Aydın, Suna; Çatak, Zekiye; Eren, Mehmet Nesimi; Topal, Askin Ender; Aydın, Süleyman

doi:10.2174/1871529x18666180511141151

Cited by 5 publications

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“…For monitoring hemodynamic parameters, a central venous catheter was inserted through the jugular vein and Swan-Ganz catheter was inserted through the femoral artery before anesthetic induction in the Cardiovascular Surgery Operating Room as described before. 29 Anesthetic induction and maintenance were performed as standard in all patients. The hemodynamic parameters measured in the Cardiovascular Surgery Operating Room were pulse heart rate (HR), mean arterial pressure (MAP), mean pulmonary arterial pressure (MPAP), and central venous pressure (CVP).…”

Section: Methodsmentioning

confidence: 99%

“…Cardiopulmonary bypass was performed as previously described using ascending aortic cannulation and two-stage venous cannulation in the right atrium. 29 The CPB circuit consisted of pipes (Cardiovascular Cannula, Shanghai International Holding Corp. GmbH, Hamburg, Germany) without an arterial line filter, with a crystalloid-colloid mixture, heparin, membrane oxygenator, and centrifugal pump (SORIN C5 Heart Lung Machine SORIN GROUP, Munchen, Germany). During aortic cross-clamping, intermittent cold blood cardioplegia is used for myocardial protection.…”

Section: Methodsmentioning

confidence: 99%

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Subfatin, Asprosin, Alamandine and Maresin-1 Inflammation Molecules in Cardiopulmonary Bypass

Hanbeyoğlu¹,

Aydın²

2023

JIR

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Purpose Cardiopulmonary bypass (CPB) is a nonphysiological procedure in which inflammatory reactions and oxidative stress are induced, hormones and hemodynamic parameters are affected, and circulation is maintained outside the body. This study aimed to examine the effects of CPB on blood subfatin (SUB), asprossin (ASP), alamandine (ALA) and maresin-1 (MaR-1) levels. Materials and Methods Controls and patients who underwent open-heart surgery with CPB and whose age and body mass indices were compatible with each other were included in the study. Venous blood samples were collected from CPB patients (n =19) before anesthesia induction (T1), before CPB (T2), 5 min before cross-clamp removal (T3), 5 min after cross-clamp removal (T4), when taken to the intensive care unit (T5), postoperative 24th hour (T6) and 72nd hour (T7) postoperatively. Venous blood was collected from the healthy controls (n =19). The amounts of SUB, ASP, ALA, and MaR-1 in the blood samples were measured using an Enzyme-Linked Immunosorbent Assay (ELISA). Results The amounts of SUB and MaR-1 in the control group were significantly higher than those in CPB patients, while these parameters in T1-T3 blood gradually decreased in CPB patients ( p <0.01). It was also reported that the amounts of ASP and ALA in the control group were significantly lower than those in CPB patients, whereas those parameters in the T1-T3 blood samples increased gradually in CPB patients, but started to decrease in T4-T7 blood samples. Conclusion These hormonal changes in the organism due to CPB demonstrate that “hormonal metabolic adaptation” mechanisms may be activated to eliminate the negative consequences of surgery. According to these data, SUB, MaR-1, anti-alamandine, and anti-asprosin could be used in CPB surgeries may come to the fore in the future to increase the safety of CPB surgeries.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Subfatin, Asprosin, Alamandine and Maresin-1 Inflammation Molecules in Cardiopulmonary Bypass

Hanbeyoğlu¹,

Aydın²

2023

JIR

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“…Similarly, the serum irisin measured 6 hours after PCI also decreased from baseline ( 76 ). However, during coronary artery bypass surgery, the serum irisin concentration increased from induction to the removal of the cross-clamp, and then gradually decreased as the patient rewarmed ( 85 ).…”

Section: Irisin In Chdmentioning

confidence: 99%

The Controversial Role of Irisin in Clinical Management of Coronary Heart Disease

Ou-Yang

Guo

et al. 2021

Front. Endocrinol.

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Irisin, a PGC1α-dependent myokine, was once believed to have beneficial effects induced by exercise. Since its first discovery of adipose browning in 2012, multiple studies have been trying to explore the metabolic functions of irisin, such as glucose and lipid metabolism. However, recently many studies with irisin concentration measuring were doubt for methodological problems, which may account for the continuous inconsistencies. New tools like recombinant irisin and gene-knockout mice are required to reconfirm the questioned functions of irisin. In this paper, we make a critical introduction to the latest researches concerning the relationship between irisin and coronary heart disease, which includes atherosclerosis, stable angina pectoris and acute coronary syndromes. These studies provided various controversial evidence of short and long-term monitoring and therapeutic effect from molecular cellular mechanisms, in vivo experiments and epidemiological investigation. But with ambiguities, irisin still has a long way to go to identify its functions in the clinical management.

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“…67 Ancak ikincil niteliğe sahip olan bu yargılama yetkisi, zamanaşımı dışında af çıkması ya da fi ilin artık suç olarak kabul edilmemesi gibi bir nedenle kovuşturmayı devreden devletin yetkisinin sona ermesi durumunda ortadan kalkacaktır. 68 Sözleşme ceza adaletini daha iyi sağlama amacını gerçekleştirebilmek için kovuşturmanın yargılama yetkisine sahip bir devle en yetkisi olmayan bir devlete naklini mümkün kılmaktadır.…”

Section: B Kovuşturmaların Aktarılmasının Kökeniunclassified

Ceza Kovuşturmalarinin Aktarilmasi

TEMİZ

2021

Uyuşmazlık Mahkemesi Dergisi

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It is one of the legal aid institutions that envisage international cooperation with the transfer of criminal proceedings, extradition of criminals, recognition of foreign decisions and transfer of convicts. The increasing traffi c of people and goods all over the world has also increased the commitment of cross-border crimes, and it has become a common situation for the perpetrator who commits a crime in one state to fl ee to another country. In criminal law, if more than one state has jurisdiction, the resolution of jurisdictional disputes between judicial authorities is more diffi cult than in private law. With the transfer of criminal proceedings, it is tried to prevent disputes on judicial power between states, and it is aimed to conduct judicial proceedings more eff ectively, in accordance with the procedural economy and in a fair manner. The importance of this institution is that it enables the transfer of the entire criminal procedure process, from investigation to execution of the sentence. It is made possible to try criminals who would have gone unpunished if they were not transferred with the institution. The subject of the study is 1972 European Convention on Transfer of Proceedings in Criminal Ma ers to which Turkey is a party . Convention is a very important international legal instrument includes provisions on the means of transferring prosecutions in the criminal area, the multiplicity of criminal proceedings, and the protection of the persons concerned against the risk of multiple prosecution and convictions. In the study, it was tried to be examined the reasons for transfer of criminal proceedings fi rstly, and then the relevant provisions of the European Convention on Transfer of Proceedings in Criminal Ma ers were tried to be examined by taking into account the relevant provisions of the Law no. 6706 on International Judicial Cooperation in Criminal Ma ers.

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Irisin in Coronary Bypass Surgery

Cited by 5 publications

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Subfatin, Asprosin, Alamandine and Maresin-1 Inflammation Molecules in Cardiopulmonary Bypass

Subfatin, Asprosin, Alamandine and Maresin-1 Inflammation Molecules in Cardiopulmonary Bypass

The Controversial Role of Irisin in Clinical Management of Coronary Heart Disease

Ceza Kovuşturmalarinin Aktarilmasi

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